Results 61 to 70 of about 5,043,774 (177)
Understanding three-dimensional chromatin organization in diploid genomes
Computational and Structural Biotechnology Journal, 2021 The three-dimensional (3D) organization of chromatin in the nucleus of diploid eukaryotic organisms has fascinated biologists for many years. Despite major progress in chromatin conformation studies, current knowledge regarding the spatial organization ...
Jing Li +3 more
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Thermodynamic pathways to genome spatial organization in the cell nucleus [PDF]
, 2009 The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex ...
A. Prisco +4 more
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BMC Bioinformatics, 2022 Background/Aim In higher eukaryotes, the three-dimensional (3D) organization of the genome is intimately related to numerous key biological functions including gene expression, DNA repair and DNA replication regulations. Alteration of 3D organization, in
Raphaël Mourad
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Analysis of 3D Genome Organization in 4-Cell Mouse Embryos
, 2023 Cell fate determination, which refers to how distinct types of signals interact with a cell to determine its fate and differentiation into a particular cell type, is a fundamental questions lying at the heart of developmental biology. Given that the type
Davarmanesh, Parmida
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Replication Timing Becomes Intertwined with 3D Genome Organization [PDF]
Cell, 2019 Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization.
Jian, Ma, Zhijun, Duan
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Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites. [PDF]
, 2019 Mounting evidence supports the idea that epigenetic, and the overall 3-dimensional (3D) architecture of the genome, plays an important role in gene expression for eukaryotic organisms.
Lenz, Todd, Le Roch, Karine
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The 3D genome in transcriptional regulation and pluripotency [PDF]
, 2014 It can be convenient to think of the genome as simply a string of nucleotides, the linear order of which encodes an organism’s genetic blueprint. However, the genome does not exist as a linear entity within cells where this blueprint is actually utilized.
Leung, Danny +3 more
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3D Organization of Eukaryotic and Prokaryotic Genomes [PDF]
, 2020 There is a complex mutual interplay between three-dimensional (3D) genome organization and cellular activities in bacteria and eukaryotes. The aim of this thesis is to investigate such structure-function relationships. A main part of this thesis deals with the study of the three-dimensional genome organization using novel techniques for detecting ...
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Frontiers in Cell and Developmental Biology, 2022 Genome-wide association studies (GWAS) have identified a vast number of variants associated with various complex human diseases and traits. However, most of these GWAS variants reside in non-coding regions producing no proteins, making the interpretation
Wujuan Zhong +7 more
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Deciphering 3D organization of chromosomes using Hi-C data
, 2018 In order to interpret data from Hi-C studies genome-wide contact probability maps need to be translated into models of functional 3D genome organization.
Hofmann, A, Heermann, DW
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