Results 61 to 70 of about 110,305 (278)
Understanding three-dimensional chromatin organization in diploid genomes
Computational and Structural Biotechnology Journal, 2021 The three-dimensional (3D) organization of chromatin in the nucleus of diploid eukaryotic organisms has fascinated biologists for many years. Despite major progress in chromatin conformation studies, current knowledge regarding the spatial organization ...
Jing Li +3 more
doaj +1 more source
Computational methods for analysing multiscale 3D genome organization. [PDF]
Nat Rev Genet, 2023 Recent progress in whole-genome mapping and imaging technologies has enabled the characterization of the spatial organization and folding of the genome in the nucleus. In parallel, advanced computational methods have been developed to leverage these mapping data to reveal multiscale three-dimensional (3D) genome features and to provide a more complete ...
Zhang Y +5 more
europepmc +3 more sources
Replication Timing Becomes Intertwined with 3D Genome Organization [PDF]
Cell, 2019 Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization.
Jian, Ma, Zhijun, Duan
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
BMC Bioinformatics, 2022 Background/Aim In higher eukaryotes, the three-dimensional (3D) organization of the genome is intimately related to numerous key biological functions including gene expression, DNA repair and DNA replication regulations. Alteration of 3D organization, in
Raphaël Mourad
doaj +1 more source
Analysis of 3D Genome Organization in 4-Cell Mouse Embryos
, 2023 Cell fate determination, which refers to how distinct types of signals interact with a cell to determine its fate and differentiation into a particular cell type, is a fundamental questions lying at the heart of developmental biology. Given that the type
Davarmanesh, Parmida
core
Three-dimensional genome organization in immune cell fate and function
, 2023 Immune cell development and activation demand the precise and coordinated control of transcriptional programmes. Three-dimensional (3D) organization of the genome has emerged as an important regulator of chromatin state, transcriptional activity and cell
Ralph Stadhouders +5 more
core +1 more source
3D Organization of Eukaryotic and Prokaryotic Genomes [PDF]
, 2020 There is a complex mutual interplay between three-dimensional (3D) genome organization and cellular activities in bacteria and eukaryotes. The aim of this thesis is to investigate such structure-function relationships. A main part of this thesis deals with the study of the three-dimensional genome organization using novel techniques for detecting ...
openaire +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source