Results 21 to 30 of about 110,305 (278)
3D genomic organization in cancers
Quantitative Biology, 2023 BackgroundThe hierarchical three‐dimensional (3D) architectures of chromatin play an important role in fundamental biological processes, such as cell differentiation, cellular senescence, and transcriptional regulation. Aberrant chromatin 3D structural alterations often present in human diseases and even cancers, but their underlying mechanisms remain ...
Junting Wang 0003 +4 more
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Understanding Regulatory Mechanisms of Brain Function and Disease through 3D Genome Organization. [PDF]
Genes (Basel), 2022 The human genome has a complex and dynamic three-dimensional (3D) organization, which plays a critical role for gene regulation and genome function. The importance of 3D genome organization in brain development and function has been well characterized in
Liu W +5 more
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Three-dimensional chromatin architecture in plants – General features and novelties
European Journal of Cell Biology, 2023 Research on the three-dimensional (3D) structure of the genome and its distribution within the nuclear space has made a big leap in the last two decades.
Edouard Tourdot, Stefan Grob
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Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples. [PDF]
Sci AdvGlioblastoma (GBM) is the most prevalent malignant brain tumor with poor prognosis. Although chromatin intratumoral heterogeneity is a characteristic feature of GBM, most current studies are conducted at a single tumor site.
Wang Q +15 more
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Mechanical determinants of chromatin topology and gene expression
Nucleus, 2022 The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin.
Rajiv Kumar Jha +2 more
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Chromatin insulators in gene regulation and 3D genome organization. [PDF]
Biochem Soc TransThe human genome attains an amazing spatial organization in the packaging of 2 m of DNA into a 10-μm nucleus. Such structural organization is achieved by the folding of chromatin and the regulation exerted by architectural proteins such as insulators. Chromatin insulators are boundary elements of the genome that, through enhancing blocking activities ...
Sultana H, Kunar R, Matera AG.
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The Functional 3D Organization of Unicellular Genomes [PDF]
Scientific Reports, 2019 AbstractGenome conformation capture techniques permit a systematic investigation into the functional spatial organization of genomes, including functional aspects like assessing the co-localization of sets of genomic elements. For example, the co-localization of genes targeted by a transcription factor (TF) within a transcription factory.
Shay Ben-Elazar +2 more
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Novel biological insights revealed from the investigation of multiscale genome architecture
Computational and Structural Biotechnology Journal, 2023 Gene expression and cell fate determination require precise and coordinated epigenetic regulation. The complex three-dimensional (3D) genome organization plays a critical role in transcription in myriad biological processes. A wide range of architectural
Tianyi Ding, He Zhang
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Nucleosome-level 3D organization of the genome [PDF]
Biochemical Society Transactions, 2018 Nucleosomes are the unitary structures of chromosome folding, and their arrangements are intimately coupled to the regulation of genome activities. Conventionally, structural analyses using electron microscopy and X-ray crystallography have been used to study such spatial nucleosome arrangements.
Masae, Ohno +2 more
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CTCF: A misguided jack-of-all-trades in cancer cells
Computational and Structural Biotechnology Journal, 2022 The emergence and progression of cancers is accompanied by a dysregulation of transcriptional programs. The three-dimensional (3D) organization of the human genome has emerged as an important multi-level mediator of gene transcription and regulation.
Julie Segueni, Daan Noordermeer
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