Results 21 to 30 of about 109,316 (244)

CTCF: A misguided jack-of-all-trades in cancer cells

Computational and Structural Biotechnology Journal, 2022
The emergence and progression of cancers is accompanied by a dysregulation of transcriptional programs. The three-dimensional (3D) organization of the human genome has emerged as an important multi-level mediator of gene transcription and regulation.
Julie Segueni, Daan Noordermeer
doaj   +1 more source

A GC-centered view of 3D genome organization

Current Opinion in Genetics & Development, 2023
In the past two decades, our understanding of how the genome of mammalian cells is spatially organized in the three-dimensional (3D) space of the nucleus and how key nuclear processes are orchestrated in this space has drastically expanded. While genome organization has been extensively studied at the nanoscale, the higher-order arrangement of ...
Bouwman, Britta AM, Crosetto, Nicola, Bienko, Magda   +2 more
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Plant 3D genomics: the exploration and application of chromatin organization [PDF]

New Phytologist, 2021
SummaryEukaryotic genomes are highly folded for packing into higher‐order chromatin structures in the nucleus. With the emergence of state‐of‐the‐art chromosome conformation capture methods and microscopic imaging techniques, the spatial organization of chromatin and its functional implications have been interrogated.
Liuling Pei, Guoliang Li, Keith Lindsey, Xianlong Zhang, Maojun Wang   +4 more
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The impact factors of 3D genome organization [PDF]

SCIENTIA SINICA Vitae, 2020
The 3D architecture of chromosomes is involved in the precision regulation of gene expression, and the changes in spatial conformation of chromosomes, accordingly, influence the biological processes in a cell. Recent findings in 3D genomics, through technological advances in approaches combining chromosome conformation capture (3C) and DNA sequencing ...
YiXian FAN, XiaoYi HANG, XiMiao HE
openaire   +1 more source

3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing

Acta Pharmaceutica Sinica B, 2021
The three-dimensional (3D) conformation of chromatin is integral to the precise regulation of gene expression. The 3D genome and genomic variations in non-alcoholic fatty liver disease (NAFLD) are largely unknown, despite their key roles in cellular ...
Lina Xu, Lianhong Yin, Yan Qi, Xuemei Tan, Meng Gao, Jinyong Peng   +5 more
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Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis

Frontiers in Genetics, 2023
Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS ...
Connor Davidson, Connor Davidson, B. Paul Wordsworth, Carla J. Cohen, Carla J. Cohen, Julian C. Knight, Matteo Vecellio, Matteo Vecellio   +7 more
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Pluripotency in 3D: genome organization in pluripotent cells [PDF]

Current Opinion in Cell Biology, 2012
Cells face the challenge of storing two meters of DNA in the three-dimensional (3D) space of the nucleus that spans only a few microns. The nuclear organization that is required to overcome this challenge must allow for the accessibility of the gene regulatory machinery to the DNA and, in the case of embryonic stem cells (ESCs), for the transcriptional
Matthew, Denholtz, Kathrin, Plath
openaire   +2 more sources

Toward understanding the dynamic state of 3D genome

Computational and Structural Biotechnology Journal, 2020
The three-dimensional (3D) genome organization and its role in biological activities have been investigated for over a decade in the field of cell biology.
Soya Shinkai, Shuichi Onami, Ryuichiro Nakato   +2 more
doaj   +1 more source

DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency

Cell Reports, 2019
Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target ...
Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore   +11 more
doaj   +1 more source

Quantifying conformational heterogeneity of 3D genome organization in fruit fly. [PDF]

PLoS One
Abstract The three-dimensional (3D) organization of interphase chromatin in eukaryotes is complex; details of the corresponding genome structures vary stochastically from cell to cell. Here, we propose a metric to quantify the cell-to-cell heterogeneity of the 3D chromatin conformations in ensembles of single cells:
Mali S, Tolokh IS, Cross E, Onufriev AV.
europepmc   +6 more sources