Results 21 to 30 of about 4,825,767 (247)

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis

Frontiers in Genetics, 2023
Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS ...
Connor Davidson, Connor Davidson, B. Paul Wordsworth, Carla J. Cohen, Carla J. Cohen, Julian C. Knight, Matteo Vecellio, Matteo Vecellio   +7 more
doaj   +1 more source

The interplay of 3D genome organization with UV-induced DNA damage and repair. [PDF]

J Biol Chem, 2023
The 3D organization of the eukaryotic genome is crucial for various cellular processes such as gene expression and epigenetic regulation, as well as for maintaining genome integrity.
Akköse Ü, Adebali O.
europepmc   +2 more sources

Toward understanding the dynamic state of 3D genome

Computational and Structural Biotechnology Journal, 2020
The three-dimensional (3D) genome organization and its role in biological activities have been investigated for over a decade in the field of cell biology.
Soya Shinkai, Shuichi Onami, Ryuichiro Nakato   +2 more
doaj   +1 more source

The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]

, 2008
We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
Joets, Johann, Moore, Jonathan D., Heslop-Harrison, J. (John), King , Graham J., Ryder, C. D., Heslop-Harrison, J. S., Joets, J., Bailey, John P., Moore, J., Ryder, Carol D., Bailey, J. P., Alix, K., Barker, G. C., King, G. J., Barker, Guy C., Alix, Karine   +15 more
core   +1 more source

3D genome organization contributes to genome instability at fragile sites

Nature Communications, 2020
Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map ...
Dan Sarni, Takayo Sasaki, Michal Irony Tur-Sinai, Karin Miron, Juan Carlos Rivera-Mulia, Brian Magnuson, Mats Ljungman, David M. Gilbert, Batsheva Kerem   +8 more
doaj   +1 more source

Three‐dimensional genome structure and function

MedComm, 2023
Linear DNA undergoes a series of compression and folding events, forming various three‐dimensional (3D) structural units in mammalian cells, including chromosomal territory, compartment, topologically associating domain, and chromatin loop.
Hao Liu, Hsiangyu Tsai, Maoquan Yang, Guozhi Li, Qian Bian, Gang Ding, Dandan Wu, Jiewen Dai   +7 more
doaj   +1 more source

Lamin C is required to establish genome organization after mitosis

Genome Biology, 2021
Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.
Xianrong Wong, Victoria E. Hoskins, Ashley J. Melendez-Perez, Jennifer C. Harr, Molly Gordon, Karen L. Reddy   +5 more
doaj   +1 more source

Comparative 3D genome architecture in vertebrates

BMC Biology, 2022
Background The three-dimensional (3D) architecture of the genome has a highly ordered and hierarchical nature, which influences the regulation of essential nuclear processes at the basis of gene expression, such as gene transcription.
Diyan Li, Mengnan He, Qianzi Tang, Shilin Tian, Jiaman Zhang, Yan Li, Danyang Wang, Long Jin, Chunyou Ning, Wei Zhu, Silu Hu, Keren Long, Jideng Ma, Jing Liu, Zhihua Zhang, Mingzhou Li   +15 more
doaj   +1 more source

Thermodynamic pathways to genome spatial organization in the cell nucleus [PDF]

, 2009
The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex ...
A. Prisco, Prisco, Antonella, Nicodemi, Mario   +2 more
core   +1 more source

Role of lamins in 3D genome organization and global gene expression

Nucleus, 2019
Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
doaj   +1 more source