Results 51 to 60 of about 24,212 (246)

A Controlled Clinical Study of Intensive Neurorehabilitation in Post-Surgical Dogs with Severe Acute Intervertebral Disc Extrusion

Animals, 2021
This retrospective controlled clinical study aimed to verify if intensive neurorehabilitation (INR) could improve ambulation faster than spontaneous recovery or conventional physiotherapy and provide a possible therapeutic approach in post-surgical ...
Ângela Martins, Débora Gouveia, Ana Cardoso, Carla Carvalho, Tiago Coelho, Cátia Silva, Inês Viegas, Óscar Gamboa, António Ferreira   +8 more
doaj   +1 more source

Human sperm ion channel (dys)function:implications for fertilization [PDF]

, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R., Brown, Sean G., Martins da Silva, Sarah J., Publicover, Stephen J.   +3 more
core   +4 more sources

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1

Cellular Physiology and Biochemistry, 2018
Background/Aims: The imbalance between excitation and inhibition is a defining feature of epilepsy. GluA1 is an AMPA receptor subunit that can strengthen excitatory synaptic transmission when upregulated in the postsynaptic membrane, which has been ...
Juan Gu, Xin Tian, Wei Wang, Qin Yang, Peijia Lin, Yuanlin Ma, Yan Xiong, Demei Xu, Yanke Zhang, Yong Yang, Shanshan Lu, Zijun Lin, Jing Luo, Fei Xiao, Xuefeng Wang   +14 more
doaj   +1 more source

Models wagging the dog: are circuits constructed with disparate parameters? [PDF]

, 2007
In a recent article, Prinz, Bucher, and Marder (2004) addressed the fundamental question of whether neural systems are built with a fixed blueprint of tightly controlled parameters or in a way in which properties can vary largely from one individual to ...
Allen I. Selverston, Arvanitaki A., Attila Szücs, Rafael Levi, Thomas Nowotny   +4 more
core   +2 more sources

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

A novel heterogeneous acid–base nano-catalyst designed based on graphene oxide for synthesis of spiro-indoline-pyranochromene derivatives

BMC Chemistry, 2023
Nano graphene oxide/3-aminopyridine has been introduced as a new, efficient and robust heterogeneous organic catalyst for synthesis of spiro-indoline-pyranochromene derivatives.
Soghra Khabnadideh, Khashayar Khorshidi, Leila Amiri-Zirtol   +2 more
doaj   +1 more source

Rapid protium-deuterium exchange of 4-aminopyridines in neutral D2O under microwave irradiation [PDF]

, 2016
4-Aminopyridines undergo surprisingly rapid and highly-selective H/D exchange at C-2 and C-6 in neutral D2O upon microwave irradiation at only 190 °C for 2 h in a sealed vessel.
Alnomsy, Ayed, Bagley, Mark C, Sharhan, Hussein I   +2 more
core   +1 more source

Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons [PDF]

, 2020
BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Bräuer, Anja U., Byvaltcev, Egor, Döhne, Noah, Grosser, Sabine, Janach, Gabriel M. S., Reetz, Olivia, Stadler, Konstantin, Strauss, Ulf   +7 more
core   +1 more source

Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose

Case Reports in Neurological Medicine, 2014
Background. 4-Aminopyridine (4-AP) is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS). Medication error can occur, as commercial preparation may not be available in some countries. Case Presentation.
Maria Ballesta Méndez, Vincent van Pesch, Arnaud Capron, Philippe Hantson   +3 more
doaj   +1 more source