Results 31 to 40 of about 13,717 (182)

Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series

Animals, 2021
This case series study aimed to evaluate the safety, feasibility, and positive outcome of the neurorehabilitation multimodal protocol (NRMP) in 16 chronic post-surgical IVDD Hansen type I dogs, with OFS 0/DPP− (n = 9) and OFS 1/DPP+ (n = 7).
Ângela Martins, Débora Gouveia, Ana Cardoso, Carla Carvalho, Cátia Silva, Tiago Coelho, Óscar Gamboa, António Ferreira   +7 more
doaj   +1 more source

Tailoring Liquid Crystalline Self‐Assembly and Photophysical Properties of Unsymmetrical Fluorenones via Polar Terminal Groups

Chemistry – A European Journal, EarlyView.
Novel liquid crystalline fluorenones bearing various head groups were synthesized and characterized. By alteration of the head group, N, SmC, or SmA phases were obtained, and emission properties could be tuned depending on solvent or temperature. ABSTRACT In this work, a series of novel unsymmetrical fluorenone derivatives bearing various head groups ...
Falk Feucht, Franziska Müller, Johanna Osterbrink, Anna Zens, Yann Molard, Sabine Laschat   +5 more
wiley   +1 more source

A Controlled Clinical Study of Intensive Neurorehabilitation in Post-Surgical Dogs with Severe Acute Intervertebral Disc Extrusion

Animals, 2021
This retrospective controlled clinical study aimed to verify if intensive neurorehabilitation (INR) could improve ambulation faster than spontaneous recovery or conventional physiotherapy and provide a possible therapeutic approach in post-surgical ...
Ângela Martins, Débora Gouveia, Ana Cardoso, Carla Carvalho, Tiago Coelho, Cátia Silva, Inês Viegas, Óscar Gamboa, António Ferreira   +8 more
doaj   +1 more source

Expanding the Scope of 1,2‐Diazepines Through Alternative Activation Strategies

European Journal of Organic Chemistry, EarlyView.
Often overlooked due to tedious synthetic routes, 1,2‐diazepines can be found in handful of biorelevant molecules. Previous reports from our group lifted the principal synthetic lock: a rapid and user‐friendly protocol to reach monocyclic 1,2‐diazepines from readily available pyridines and electrophilic activating groups. Herein, we extend the scope of
Alexis Leblais, Diego Robles, Aurélie Damond, Xavier Moreau, Clément Ghiazza   +4 more
wiley   +1 more source

Optical triggered seizures using a caged 4-Aminopyridine

Frontiers in Neuroscience, 2015
Animal models of epilepsy are critical not only for understanding the fundamental mechanism of epilepsy but also for testing the efficacy of new antiepileptic drugs and novel therapeutic interventions.
Mingrui eZhao, Laura M. McGarry, Hongtao eMa, Sam eHarris, Sam eHarris, Jason eBerwick, Rafael eYuste, Theodore eSchwartz   +7 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Anti-proliferative and anti-angiogenic activities of ion-channel modulators: In-ovo, in-vitro and in-vivo study

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: Angiogenesis is the development of new blood vessels. The ion channels on endothelium play a vital action in cell proliferation and so in the related angiogenesis.
Chandana Kamili, Ravi Shankar Kakataparthy, Uma Maheshwararao Vattikutti, Vijay Chidrawar, Sindhuri Ammineni   +4 more
doaj   +1 more source

A novel heterogeneous acid–base nano-catalyst designed based on graphene oxide for synthesis of spiro-indoline-pyranochromene derivatives

BMC Chemistry, 2023
Nano graphene oxide/3-aminopyridine has been introduced as a new, efficient and robust heterogeneous organic catalyst for synthesis of spiro-indoline-pyranochromene derivatives.
Soghra Khabnadideh, Khashayar Khorshidi, Leila Amiri-Zirtol   +2 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Responsiveness to progesterone and potassium channel blockers 4-aminopyridine, tetraethylammonium and free Ca(2+) contentration in spermatozoa of patients with oligozoospermia/leucocytospermia

The Ukrainian Biochemical Journal, 2018
The present study was undertaken to evaluate [Ca2+]i signals that occur in human sperm cells exposed in vitro to three diverse compounds; progesterone, 4-aminopyridine (a highly effective inducer of hyperactivation in human sperm) and tetraethylammonium.
R. V. Fafula, G. V. Danylovych, A. S. Besedina, O. V. Melnyk, Z. D. Vorobets   +4 more
doaj   +1 more source