Results 31 to 40 of about 13,554 (179)

Effects of 4- Aminopyridine on Inflammatory Reactions in Experimental Models [PDF]

پیاورد سلامت, 2009
Background And Aim : Nowadays, many inflammatory diseases such as rheumatoid arthritis (RA) and Multiple sclerosis (MS) and many other autoimmune inflammatory diseases has involved the people of different communities and cure for them so far has not been
SA Mirshafyei, V Molakazemiha, MM Amiri, A Salehinodeh, A Razavi, MR Khoramizadeh, R Gholamnejad   +6 more
doaj   +2 more sources

4-Aminopyridine inhibits the neuromuscular effects of nitric oxide and 8-Br-cGMP

Brazilian Journal of Medical and Biological Research, 2003
The effects induced by nitric oxide (NO) in different tissues depend on direct and/or indirect interactions with K+ channels. The indirect interaction of NO is produced by activation of guanylyl cyclase which increases the intracellular cGMP.
R.N. Queiroz, E.R.P. Ramos, W. Alves-Do-Prado   +2 more
doaj   +1 more source

HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report

Case Reports in Neurology, 2017
Apart from infectious causes and cerebellar dysfunction associated with acquired immune deficiency syndrome dementia or HIV-associated neurocognitive disorder, cerebellar dysfunction in HIV-positive individuals has been ascribed to granule cell ...
Carolin Hoyer, Angelika Alonso, Beate Schlotter-Weigel, Michael Platten, Marc Fatar   +4 more
doaj   +1 more source

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase

Beilstein Journal of Organic Chemistry, 2009
Highly potent and selective inhibitors of neuronal nitric oxide synthase (nNOS) possessing a 2-aminopyridine group were recently designed and synthesized in our laboratory and were shown to have significant in vivo efficacy.
Graham R. Lawton, Haitao Ji, Pavel Martásek, Linda J. Roman, Richard B. Silverman   +4 more
doaj   +1 more source

Spatiotemporal Correlation of Epileptiform Activity and Gene Expression in vitro

Frontiers in Molecular Neuroscience, 2021
Epileptiform activity alters gene expression in the central nervous system, a phenomenon that has been studied extensively in animal models. Here, we asked whether also in vitro models of seizures are in principle suitable to investigate changes in gene ...
Sophie Schlabitz, Laura Monni, Alienor Ragot, Matthias Dipper-Wawra, Julia Onken, Martin Holtkamp, Martin Holtkamp, Pawel Fidzinski, Pawel Fidzinski, Pawel Fidzinski   +9 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 4-aminopyridinium thiocyanate–4-aminopyridine (1/1)

Acta Crystallographica Section E: Crystallographic Communications, 2020
In the crystals of the title compound, C5H7N2+·CNS−·C5H6N2, the components are linked by three N—H...N and two N—H...S hydrogen bonds, resulting in two interpenetrating three-dimensional networks.
M. Renugadevi, A. Sinthiya, Kumaradhas Poomani, Suganya Suresh   +3 more
doaj   +1 more source

Chlorido(4-methylpyridin-2-amine-κN1)(2-{[(4-methylpyridin-2-yl)imino-κN]methyl}phenolato-κO)copper(II)

Acta Crystallographica Section E, 2012
In the title complex, [Cu(C13H11N2O)Cl(C6H8N2)], the CuII atom adopts a distorted tetrahedral geometry being coordinated by the phenolic O atom and the azomethine N atom of the Schiff base ligand N-salicylidene 2-aminopyridine, and by the 2-aminopyridine
Bussa Bhagyaraju, P. Sambasiva Rao, Toka Swu   +2 more
doaj   +1 more source

Optical triggered seizures using a caged 4-Aminopyridine

Frontiers in Neuroscience, 2015
Animal models of epilepsy are critical not only for understanding the fundamental mechanism of epilepsy but also for testing the efficacy of new antiepileptic drugs and novel therapeutic interventions.
Mingrui eZhao, Laura M. McGarry, Hongtao eMa, Sam eHarris, Sam eHarris, Jason eBerwick, Rafael eYuste, Theodore eSchwartz   +7 more
doaj   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Two new mononuclear manganese(III) salen complexes

Acta Chimica Slovenica, 2014
Two new Mn(III)-salen complexes with 4-aminopyridine (4-apy) have been prepared and structurally characterized. [Mn(ac)(4-apy)(sal)], 1,exhibits mononuclear molecular structure with an octahedral environment around the Mn center.
Nina Lah, Sabina Grabner, Peter Bukovec
doaj   +1 more source