Results 41 to 50 of about 13,717 (182)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

A COMPARISON OF THE FACILITATORY ACTIONS OF 4‐AMINOPYRI‐DINE METHIODIDE AND 4‐AMINOPYRIDINE ON NEUROMUSCULAR TRANSMISSION [PDF]

British Journal of Pharmacology, 1979
4‐Aminopyridine methiodide (4‐APMI), a quaternary analogue of aminopyridine (4‐AP), was tested for neuromuscular facilitatory actions on the chick biventer cervicis and frog sartorius nerve‐muscle preparations. In the chick, 4‐APMI (10−4 to 10−2m) augmented indirectly elicited twitches and reversed tubocurarine‐induced neuromuscular block. Reversal of
Horn, A. S., Lambert, J. J., Marshall, I. G.   +2 more
openaire   +3 more sources

Movement Disorders in Developmental and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad, Darius Ebrahimi‐Fakhari, Hugo Morales‐Briceno   +2 more
wiley   +1 more source

Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose

Case Reports in Neurological Medicine, 2014
Background. 4-Aminopyridine (4-AP) is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS). Medication error can occur, as commercial preparation may not be available in some countries. Case Presentation.
Maria Ballesta Méndez, Vincent van Pesch, Arnaud Capron, Philippe Hantson   +3 more
doaj   +1 more source

Amiodarone reduces depolarization-evoked glutamate release from hippocampual synaptosomes

Journal of Pharmacological Sciences, 2017
Decreased brain glutamate level has emerged as a new therapeutic approach for epilepsy. This study investigated the effect and mechanism of amiodarone, an anti-arrhythmic drug with antiepileptic activity, on glutamate release in the rat hippocampus. In a
Chia Yu Chang, Chi Feng Hung, Shu Kuei Huang, Jinn Rung Kuo, Su Jane Wang   +4 more
doaj   +1 more source

Curing Behavior and Adhesion Performance of a One‐Component Epoxy Resin Based on a Dual‐Locked Thermal Latent Curing Agent

Journal of Polymer Science, EarlyView.
In this study, curing behavior of epoxy resins using a dual‐locked thermal latent curing agent (DCA) was analyzed using DSC and FT‐NIR. The DCA was successfully dissolved in the bisphenol A type epoxy resin (DGEBA). Furthermore, the prepared one‐component epoxy resin was used as an adhesive and achieved excellent adhesive strength (> 25 MPa).
Yukai Ito, Daisuke Aoki, Koji Arimitsu
wiley   +1 more source

Role of K+ Channels in M2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach

Journal of Pharmacological Sciences, 2004
Previously we reported the cholinergic M2 muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach (K. Yokotani, Y. Osumi. J Pharmacol Exp Ther. 1993;264:54–60).
Kumiko Nakamura, Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Keiko Yokotani, Kunihiko Yokotani   +5 more
doaj   +1 more source

The mechanics of hyperactivation in adhered human sperm [PDF]

Royal Society Open Science, 2014
Hyperactivation is an important phenomenon exhibited by mammalian sperm during the process of acquiring fertilization capacity. The majority of studies have focused on incubation-induced hyperactivation in non-human species, which typically differ in ...
E. H Ooi, D. J Smith, H Gadêlha, E. A Gaffney, J Kirkman-Brown   +4 more
doaj   +1 more source

The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level

Smart Molecules, EarlyView.
The GWT1‐targeted azobenzene‐aminopyridine derivatives (ABAMIs), sensitive to the light at wavelengths from 365 to 520 nm, are separately developed as photochromic ligands to regulate bioactivity as well as the GWT1 functions. These molecules are smart tools in photopharmacological studies, giving an innovative method for understanding functional GWT1 ...
Qian Ding, Zongying Li, Zaiwei Xiao, Siting Zhang, Zimai Liu, Xiaoguang Shao, Zhong Li, Wen Fu, Xusheng Shao   +8 more
wiley   +1 more source

Inhibition of 4-aminopyridine-induced seizures in mice by a novel 3-substituted 1,4-benzodiazepine

Фармацевтичний журнал, 2019
Some of highly effective antiepileptic substances share the polymodal pharmacological action which determines the possibility of their use for treatment of pathogenetically similar diseases. Inhibitory mediator systems influence for example, suggests the
N. Ya. Golovenko, V. B. Larionov, A. S. Reder, I. P. Valivodz’   +3 more
doaj   +1 more source