Results 21 to 30 of about 13,554 (179)
4-Aminopyridine — A Review [PDF]
Anaesthesia and Intensive Care, 1982 4-aminopyridine is the first of the aminopyridines to be used in clinical practice. It blocks potassium channels and thereby increases acetylcholine, and possibly noradrenaline, release at nerve terminals. In man the drug has a significant action at the neuromuscular junction, but has little effect on the autonomic nervous system or muscle (smooth ...
N, Soni, P, Kam
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4-aminopyridine – the new old drug for the treatment of neurodegenerative diseases [PDF]
Pharmacia, 2019 In this review are described the preclinical and clinical pharmacological data as well as new therapeutic indications for the use of 4-aminopyridine.
Ivanka Kostadinova, Nikolai Danchev
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Chemistry Proceedings, 2021 In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by ...
Fadila Salhi +3 more
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International Clinical Neuroscience Journal, 2015 Background and purpose: Progressive degeneration of dopaminergic neurons in the midbrain is the main mechanism of Parkinson’s disease (PD). Although potassium channels affect neural activity and death in this area, little research has investigated the ...
Reza Taherian, Mehran Arab Ahmadi
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The crystal structure of poly[bis(μ2−3−aminopyridine−4−carboxylato−κ2N:O)Zinc(II)], [Zn(C6H5N2O2)2]n
Zeitschrift für Kristallographie - New Crystal Structures, 2023 [Zn(C6H5N2O2)2${({\mathrm{C}}_{6}{\mathrm{H}}_{5}{\mathrm{N}}_{2}{\mathrm{O}}_{2})}_{2}$]n, orthorhombic, P212121 (no. 19), a = 7.6139(7) Å, b = 12.4890(13) Å, c = 13.9382(13) Å, V = 1325.4(2) Å3, Z = 4, Rgt(F) = 0.0391, wRref(F2) = 0.0710, T = 296 K.
Liu Fang-Fang +3 more
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4-Aminopyridinium azide 4-aminopyridine solvate
Acta Crystallographica Section E, 2010 In the title compound, C5H7N2+·N3−·C5H6N2, all N atoms of the azide anion are situated on a twofold rotational axis, so the 4-aminopyridinium cation and 4-aminopyridine molecule, being related by symmetry, occupy one position ...
Hui-Fen Qian, Wei Huang
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Two new zinc(II) acetates with 3– and 4–aminopyridine: syntheses and structural properties
Acta Chimica Slovenica, 2015 The synthesis and characterization of two new zinc(II) coordination compounds with 3– and 4–aminopyridine are reported. They were obtained after dissolving Zn(CH3COO)2·2H2O in different solutions of 3– and 4–aminopyridine. The products were characterized
Brina Dojer +3 more
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Hydroxyapatite and Silicon-Modified Hydroxyapatite as Drug Carriers for 4-Aminopyridine
Crystals, 2021 Adsorption and desorption properties of nano-hydroxyapatite (HAP) and silicon-modified hydroxyapatite (Si–HAP) were investigated with 4-aminopyridine (fampridine-4AP). The novelty of this research is the investigation of the suitability of the previously
Laura Marincaș +7 more
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Revista Brasileira de Anestesiologia, 2015 BACKGROUND AND OBJECTIVES: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental ...
Angélica de Fátima Braga +4 more
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Synthesis and Characterization of Palladium (II) Complexes With Some Pyridine Derivatives
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2008 Complexes of palladium (II) with pyridine derivatives in general formula: trans- [PdCl2L1 2], (where: L1 = 2- picoline, 3- picoline, 4- picoline); [pd L1 4](BF4) 2, (Where: L1=3-picoline, 4-picoline); trans- [PdCl2L2 2] and [pd L2 4] (BF4) 2, (Where: L2
M. J. Al-Jeboori +2 more
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