Results 21 to 30 of about 13,717 (182)

Effects of 4- Aminopyridine on Inflammatory Reactions in Experimental Models [PDF]

پیاورد سلامت, 2009
Background And Aim : Nowadays, many inflammatory diseases such as rheumatoid arthritis (RA) and Multiple sclerosis (MS) and many other autoimmune inflammatory diseases has involved the people of different communities and cure for them so far has not been
SA Mirshafyei, V Molakazemiha, MM Amiri, A Salehinodeh, A Razavi, MR Khoramizadeh, R Gholamnejad   +6 more
doaj   +2 more sources

4-Aminopyridine inhibits the neuromuscular effects of nitric oxide and 8-Br-cGMP

Brazilian Journal of Medical and Biological Research, 2003
The effects induced by nitric oxide (NO) in different tissues depend on direct and/or indirect interactions with K+ channels. The indirect interaction of NO is produced by activation of guanylyl cyclase which increases the intracellular cGMP.
R.N. Queiroz, E.R.P. Ramos, W. Alves-Do-Prado   +2 more
doaj   +1 more source

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase

Beilstein Journal of Organic Chemistry, 2009
Highly potent and selective inhibitors of neuronal nitric oxide synthase (nNOS) possessing a 2-aminopyridine group were recently designed and synthesized in our laboratory and were shown to have significant in vivo efficacy.
Graham R. Lawton, Haitao Ji, Pavel Martásek, Linda J. Roman, Richard B. Silverman   +4 more
doaj   +1 more source

HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report

Case Reports in Neurology, 2017
Apart from infectious causes and cerebellar dysfunction associated with acquired immune deficiency syndrome dementia or HIV-associated neurocognitive disorder, cerebellar dysfunction in HIV-positive individuals has been ascribed to granule cell ...
Carolin Hoyer, Angelika Alonso, Beate Schlotter-Weigel, Michael Platten, Marc Fatar   +4 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 4-aminopyridinium thiocyanate–4-aminopyridine (1/1)

Acta Crystallographica Section E: Crystallographic Communications, 2020
In the crystals of the title compound, C5H7N2+·CNS−·C5H6N2, the components are linked by three N—H...N and two N—H...S hydrogen bonds, resulting in two interpenetrating three-dimensional networks.
M. Renugadevi, A. Sinthiya, Kumaradhas Poomani, Suganya Suresh   +3 more
doaj   +1 more source

Spatiotemporal Correlation of Epileptiform Activity and Gene Expression in vitro

Frontiers in Molecular Neuroscience, 2021
Epileptiform activity alters gene expression in the central nervous system, a phenomenon that has been studied extensively in animal models. Here, we asked whether also in vitro models of seizures are in principle suitable to investigate changes in gene ...
Sophie Schlabitz, Laura Monni, Alienor Ragot, Matthias Dipper-Wawra, Julia Onken, Martin Holtkamp, Martin Holtkamp, Pawel Fidzinski, Pawel Fidzinski, Pawel Fidzinski   +9 more
doaj   +1 more source

Chlorido(4-methylpyridin-2-amine-κN1)(2-{[(4-methylpyridin-2-yl)imino-κN]methyl}phenolato-κO)copper(II)

Acta Crystallographica Section E, 2012
In the title complex, [Cu(C13H11N2O)Cl(C6H8N2)], the CuII atom adopts a distorted tetrahedral geometry being coordinated by the phenolic O atom and the azomethine N atom of the Schiff base ligand N-salicylidene 2-aminopyridine, and by the 2-aminopyridine
Bussa Bhagyaraju, P. Sambasiva Rao, Toka Swu   +2 more
doaj   +1 more source

Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1

Cellular Physiology and Biochemistry, 2018
Background/Aims: The imbalance between excitation and inhibition is a defining feature of epilepsy. GluA1 is an AMPA receptor subunit that can strengthen excitatory synaptic transmission when upregulated in the postsynaptic membrane, which has been ...
Juan Gu, Xin Tian, Wei Wang, Qin Yang, Peijia Lin, Yuanlin Ma, Yan Xiong, Demei Xu, Yanke Zhang, Yong Yang, Shanshan Lu, Zijun Lin, Jing Luo, Fei Xiao, Xuefeng Wang   +14 more
doaj   +1 more source

Photo‐Triggered, Fast, and Fluorogenic Thiophene‐Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3‐Dipole‐Tagged Molecules in No‐Wash Conditions

Angewandte Chemie International Edition, EarlyView.
Thiophene is king! The fusion of thiophene rings to cycloalkynes super‐charged their copper‐free click chemistry applications, by (1) enhancing the alkyne reactivity (fastest cyclooctyne to date) and (2) rendering the alkyne fluorogenic (with fluorescence enhancement up to 150‐fold upon reaction), making these bioorthogonal reagents ideal for tracking ...
Jurgen Schulz, Zoeisha S. Chinoy, Tarek Khalaf, Yukang Li, Pengchen Ma, Dennis Svatunek, Kendall N. Houk, Frédéric Friscourt   +7 more
wiley   +1 more source

Two new mononuclear manganese(III) salen complexes

Acta Chimica Slovenica, 2014
Two new Mn(III)-salen complexes with 4-aminopyridine (4-apy) have been prepared and structurally characterized. [Mn(ac)(4-apy)(sal)], 1,exhibits mononuclear molecular structure with an octahedral environment around the Mn center.
Nina Lah, Sabina Grabner, Peter Bukovec
doaj   +1 more source