Results 11 to 20 of about 21,958 (218)
GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohortResearch in context [PDF]
EBioMedicineSummary: Background: GAA-FGF14 disease/spinocerebellar ataxia 27B is a recently described neurodegenerative disease caused by (GAA)≥250 expansions in the fibroblast growth factor 14 (FGF14) gene, but its phenotypic spectrum, pathogenic threshold, and ...
David Pellerin +16 more
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4-Aminopyridine treatment for nerve injury resulting from radical retro-pubic prostatectomy: a single-center double-blind, randomized, placebo-controlled study [PDF]
TrialsBackground Prostate cancer (PCa) is the most common non-cutaneous malignancy in men and leads to the second most common cause of cancer related mortality in men. Early detection of PCa allows for a potentially curative intervention.
Ahmed Ghazi +4 more
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PHOTOACTINIC IRRADIATION EFFECT ON REFRACTION INDICE OF ORGANIC CO-CRYSTALS BASED ON AMINOPYRIDINE SERIES [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2020 Subject of Research. The paper presents research of photoactinic radiation effect on refractive indice of organic nonlinear optical co-crystals: 2.6-diaminopyridine-4-nitrophenol and 4-aminopyridine-4-nitrophenol. Method. The research technique included
Kirill E. Zhevaikin +2 more
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4-Aminopyridine — A Review [PDF]
Anaesthesia and Intensive Care, 1982 4-aminopyridine is the first of the aminopyridines to be used in clinical practice. It blocks potassium channels and thereby increases acetylcholine, and possibly noradrenaline, release at nerve terminals. In man the drug has a significant action at the neuromuscular junction, but has little effect on the autonomic nervous system or muscle (smooth ...
N, Soni, P, Kam
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4-aminopyridine – the new old drug for the treatment of neurodegenerative diseases [PDF]
Pharmacia, 2019 In this review are described the preclinical and clinical pharmacological data as well as new therapeutic indications for the use of 4-aminopyridine.
Ivanka Kostadinova, Nikolai Danchev
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Chemistry Proceedings, 2021 In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by ...
Fadila Salhi +3 more
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International Clinical Neuroscience Journal, 2015 Background and purpose: Progressive degeneration of dopaminergic neurons in the midbrain is the main mechanism of Parkinson’s disease (PD). Although potassium channels affect neural activity and death in this area, little research has investigated the ...
Reza Taherian, Mehran Arab Ahmadi
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The crystal structure of poly[bis(μ2−3−aminopyridine−4−carboxylato−κ2N:O)Zinc(II)], [Zn(C6H5N2O2)2]n
Zeitschrift für Kristallographie - New Crystal Structures, 2023 [Zn(C6H5N2O2)2${({\mathrm{C}}_{6}{\mathrm{H}}_{5}{\mathrm{N}}_{2}{\mathrm{O}}_{2})}_{2}$]n, orthorhombic, P212121 (no. 19), a = 7.6139(7) Å, b = 12.4890(13) Å, c = 13.9382(13) Å, V = 1325.4(2) Å3, Z = 4, Rgt(F) = 0.0391, wRref(F2) = 0.0710, T = 296 K.
Liu Fang-Fang +3 more
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Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]
, 1982 The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Baranyi +47 more
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4-Aminopyridinium azide 4-aminopyridine solvate
Acta Crystallographica Section E, 2010 In the title compound, C5H7N2+·N3−·C5H6N2, all N atoms of the azide anion are situated on a twofold rotational axis, so the 4-aminopyridinium cation and 4-aminopyridine molecule, being related by symmetry, occupy one position ...
Hui-Fen Qian, Wei Huang
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