KCNA1 gain‐of‐function epileptic encephalopathy treated with 4‐aminopyridine [PDF]
Annals of Clinical and Translational Neurology, 2023 Precision medicine for Mendelian epilepsy is rapidly developing. We describe an early infant with severely pharmacoresistant multifocal epilepsy. Exome sequencing revealed the de novo variant p.(Leu296Phe) in the gene KCNA1, encoding the voltage‐gated K+
Peter Müller +10 more
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Functional improvement in individuals with chronic spinal cord injury treated with 4-aminopyridine: A systematic review [PDF]
Frontiers in Neurology, 2022 Study designSystematic review.ObjectiveTo provide current evidence on the efficacy of 4-aminopyridine (4-AP) to bring about functional improvement in individuals with chronic traumatic spinal cord injury (SCI).MethodsThe Medline (PubMed), Web of Science ...
Martin Paredes-Cruz +6 more
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Sleep Deprivation‐Induced Anxiety Alleviated by Oral Administration of 4‐Aminopyridine in Male Mice [PDF]
Brain and BehaviorPurpose Insufficient sleep and insomnia are common issues associated with modern lifestyles that often contribute to the development of mental health disorders.
Ehsan Hosseini
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Mapping the secondary response to traumatic brain injury using spatial transcriptomics shows acute 4-aminopyridine treatment mitigates axonal and molecular pathology [PDF]
Acta Neuropathologica CommunicationsDamage to long myelinated axons of white matter tracts is a hallmark pathology resulting from traumatic brain injury (TBI) forces and secondary injury processes.
Genevieve M. Sullivan +8 more
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4‐Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury
EMBO Molecular Medicine, 2016 Traumatic peripheral nerve damage is a major medical problem without effective treatment options. In repurposing studies on 4‐aminopyridine (4‐AP), a potassium channel blocker that provides symptomatic relief in some chronic neurological afflictions, we ...
Michael J Zuscik +2 more
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Phase IIB Randomized Trial on the Use of 4-Aminopyridine in Guillain-Barré Syndrome [PDF]
Archives of Rehabilitation Research and Clinical Translation, 2021 Objective: To determine the safety and efficacy of orally delivered 4-aminopyridine (4-AP) in persons with Guillain-Barré Syndrome (GBS) >6 months from initial diagnosis. Design: A randomized, double-blind, placebo-controlled, crossover study.
Jay M. Meythaler, JD, MD +2 more
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GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohortResearch in context [PDF]
EBioMedicineSummary: Background: GAA-FGF14 disease/spinocerebellar ataxia 27B is a recently described neurodegenerative disease caused by (GAA)≥250 expansions in the fibroblast growth factor 14 (FGF14) gene, but its phenotypic spectrum, pathogenic threshold, and ...
David Pellerin +16 more
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4-Aminopyridine treatment for nerve injury resulting from radical retro-pubic prostatectomy: a single-center double-blind, randomized, placebo-controlled study [PDF]
TrialsBackground Prostate cancer (PCa) is the most common non-cutaneous malignancy in men and leads to the second most common cause of cancer related mortality in men. Early detection of PCa allows for a potentially curative intervention.
Ahmed Ghazi +4 more
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Neuroprotective Properties of 4-Aminopyridine. [PDF]
Neurol Neuroimmunol Neuroinflamm, 2021 As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used as symptomatic therapy in several neurologic disorders. The improvement of visual function and motor skills and relieve of fatigue in patients with MS have been attributed to 4-AP.
Dietrich M, Hartung HP, Albrecht P.
europepmc +4 more sources
PHOTOACTINIC IRRADIATION EFFECT ON REFRACTION INDICE OF ORGANIC CO-CRYSTALS BASED ON AMINOPYRIDINE SERIES [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2020 Subject of Research. The paper presents research of photoactinic radiation effect on refractive indice of organic nonlinear optical co-crystals: 2.6-diaminopyridine-4-nitrophenol and 4-aminopyridine-4-nitrophenol. Method. The research technique included
Kirill E. Zhevaikin +2 more
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