Results 51 to 60 of about 21,958 (218)

Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1

Cellular Physiology and Biochemistry, 2018
Background/Aims: The imbalance between excitation and inhibition is a defining feature of epilepsy. GluA1 is an AMPA receptor subunit that can strengthen excitatory synaptic transmission when upregulated in the postsynaptic membrane, which has been ...
Juan Gu, Xin Tian, Wei Wang, Qin Yang, Peijia Lin, Yuanlin Ma, Yan Xiong, Demei Xu, Yanke Zhang, Yong Yang, Shanshan Lu, Zijun Lin, Jing Luo, Fei Xiao, Xuefeng Wang   +14 more
doaj   +1 more source

A Controlled Clinical Study of Intensive Neurorehabilitation in Post-Surgical Dogs with Severe Acute Intervertebral Disc Extrusion

Animals, 2021
This retrospective controlled clinical study aimed to verify if intensive neurorehabilitation (INR) could improve ambulation faster than spontaneous recovery or conventional physiotherapy and provide a possible therapeutic approach in post-surgical ...
Ângela Martins, Débora Gouveia, Ana Cardoso, Carla Carvalho, Tiago Coelho, Cátia Silva, Inês Viegas, Óscar Gamboa, António Ferreira   +8 more
doaj   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

A COMPARISON OF THE FACILITATORY ACTIONS OF 4‐AMINOPYRI‐DINE METHIODIDE AND 4‐AMINOPYRIDINE ON NEUROMUSCULAR TRANSMISSION [PDF]

British Journal of Pharmacology, 1979
4‐Aminopyridine methiodide (4‐APMI), a quaternary analogue of aminopyridine (4‐AP), was tested for neuromuscular facilitatory actions on the chick biventer cervicis and frog sartorius nerve‐muscle preparations. In the chick, 4‐APMI (10−4 to 10−2m) augmented indirectly elicited twitches and reversed tubocurarine‐induced neuromuscular block. Reversal of
Horn, A. S., Lambert, J. J., Marshall, I. G.   +2 more
openaire   +3 more sources

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose

Case Reports in Neurological Medicine, 2014
Background. 4-Aminopyridine (4-AP) is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS). Medication error can occur, as commercial preparation may not be available in some countries. Case Presentation.
Maria Ballesta Méndez, Vincent van Pesch, Arnaud Capron, Philippe Hantson   +3 more
doaj   +1 more source

Anti-proliferative and anti-angiogenic activities of ion-channel modulators: In-ovo, in-vitro and in-vivo study

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: Angiogenesis is the development of new blood vessels. The ion channels on endothelium play a vital action in cell proliferation and so in the related angiogenesis.
Chandana Kamili, Ravi Shankar Kakataparthy, Uma Maheshwararao Vattikutti, Vijay Chidrawar, Sindhuri Ammineni   +4 more
doaj   +1 more source

A novel heterogeneous acid–base nano-catalyst designed based on graphene oxide for synthesis of spiro-indoline-pyranochromene derivatives

BMC Chemistry, 2023
Nano graphene oxide/3-aminopyridine has been introduced as a new, efficient and robust heterogeneous organic catalyst for synthesis of spiro-indoline-pyranochromene derivatives.
Soghra Khabnadideh, Khashayar Khorshidi, Leila Amiri-Zirtol   +2 more
doaj   +1 more source

Models wagging the dog: are circuits constructed with disparate parameters? [PDF]

, 2007
In a recent article, Prinz, Bucher, and Marder (2004) addressed the fundamental question of whether neural systems are built with a fixed blueprint of tightly controlled parameters or in a way in which properties can vary largely from one individual to ...
Allen I. Selverston, Arvanitaki A., Attila Szücs, Rafael Levi, Thomas Nowotny   +4 more
core   +2 more sources

Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways

European Journal of Organic Chemistry, EarlyView.
Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian, Andrea Serafino, Luc Neuville, Géraldine Masson   +3 more
wiley   +1 more source