Results 21 to 30 of about 4,514 (173)

4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease

Pharmaceutics, 2022
Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human ...
Katarina Komatović, Ana Matošević, Nataša Terzić-Jovanović, Suzana Žunec, Sandra Šegan, Mario Zlatović, Nikola Maraković, Anita Bosak, Dejan M. Opsenica   +8 more
doaj   +1 more source

3-Acetyl-4-aminoquinoline

Acta Crystallographica Section E Structure Reports Online, 2007
The title compound, C11H10N2O, a potential antitumour drug, crystallizes with two molecules in the asymmetric unit. The 4-amino N atom is strongly conjugated with the quinoline ring involving the 3-carbonyl group. As a result, the molecule is almost planar.
Jan Lokaj, Viktor Kettmann, Petra Černuchová, Viktor Milata, Marek Fronc   +4 more
openaire   +1 more source

Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: Synthesis, characterization, antimicrobial and toxicology study [PDF]

, 2012
Two new mixed ligands metal complexes of sulphadoxine and pyramethamine were prepared by using CuCl2.6H2O and FeCl3.6H2O. The complexes were characterized by elemental analysis, melting point determination, molar conductivity, metal content analysis (AAS)
Adekoya, J. A., Ajanaku, K. O., Ajani, O. O., Ehi-Eromosele, C. O., Obaleye, J. A., Ogunniran, K. O.   +5 more
core   +4 more sources

Genotype-phenotype association and biochemical analyses of glucose-6-phosphate dehydrogenase variants: Implications for the hemolytic risk of using 8-aminoquinolines for radical cure

Frontiers in Pharmacology, 2022
Background:Plasmodium vivax remains the malaria species posing a major threat to human health worldwide owing to its relapse mechanism. Currently, the only drugs of choice for radical cure are the 8-aminoquinolines (primaquine and tafenoquine), which are
Sirapapha Sudsumrit, Kamonwan Chamchoy, Duantida Songdej, Poom Adisakwattana, Srivicha Krudsood, Emily R. Adams, Mallika Imwong, Ubolsree Leartsakulpanich, Usa Boonyuen   +8 more
doaj   +1 more source

Evaluation of the biological activity of different 4-aminoquinolines for the development of new drugs against painful and inflammatory disorders

European Journal of Medicinal Chemistry Reports, 2023
The potential biological properties of four 4-aminoquinoline derivatives (1–4) have been previously demonstrated. However, the evaluation of important aspects of their toxicity, anti-inflammatory, and antinociceptive activities has not been described ...
Geraldo José da Silva Neto, Suellen Maria Albuquerque da Silva, Daniele Costa Souza Barros, Alyne Almeida de Lima, Max Denisson Maurício Viana, Magna Suzana Alexandre Moreira, Mario Roberto Meneghetti, Eliane Aparecida Campesatto   +7 more
doaj   +1 more source

Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines [PDF]

, 2015
We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability.
Artigas, Albert, Clos, Victòria, Gbedema, Stephen Y., Kelly, John M., Muñoz-Torrero López-Ibarra, Diego, Pérez Fernández, Belén, Sola, Irene, Taylor, Martin C., Wright, Colin W.   +8 more
core   +2 more sources

Use of connectivity index and simple topological parameters for estimating the inhibition potency of acetylcholinesterase

Saudi Pharmaceutical Journal, 2022
Acetylcholinesterase (AChE) has proven to be an effective drug target in the treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and dementia. We developed a novel QSAR regression model for estimating potency to inhibit AChE, pKi, on
Ante Miličević, Goran Šinko
doaj   +1 more source

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Stepniewska, K, Taylor, W R J, Mayxay, M, Price, R, Smithuis, F, Guthmann, J P, Barnes, K, Myint, H Y, Adjuik, M, Olliaro, P, Pukrittayakamee, S, Looareesuwan, S, Hien, T T, Farrar, J, Nosten, F, Day, N P J, White, N J   +16 more
core   +2 more sources

Saquinavir Inhibits the malaria parasite's chloroquine resistance transporter [PDF]

, 2012
The antiretroviral protease inhibitors (APIs) ritonavir, saquinavir, and lopinavir, used to treat HIV infection, inhibit the growth of Plasmodium falciparum at clinically relevant concentrations.
Alice S. Butterworth, Allen, Andrews, Berenbaum, Canfield, Djimde, Donald L. Gardiner, Dubar, Ferreira, Fidock, Foote, Ford, Hasegawa, Hayward, He, He, Hocart, James S. McCarthy, Kashuba, Kiaran Kirk, Kumar, Launay, Lehane, Martin, Nsanzabana, Olliaro, Parikh, Ray, Redmond, Reed, Rowena E. Martin, Saliba, Sidhu, Sidhu, Skinner-Adams, Skinner-Adams, Skinner-Adams, Su, Tina S. Skinner-Adams, Trager, Ursing, Wellems, Wlodawer, Yuan   +43 more
core   +1 more source

Design, Synthesis and Potential Anti-Proliferative Activity of Some Novel 4-Aminoquinoline Derivatives

Acta Pharmaceutica, 2014
Novel nineteen compounds based on a 4-aminoquinoline scaffold were designed and synthesized as potential antiproliferative agents. The new compounds were N-substituted at the 4-position by aryl or heteroaryl (1-9), quinolin- 3-yl (10), 2-methylquinolin-3-
Ghorab Mostafa M., Al-Said Mansour S., Arafa Reem K.   +2 more
doaj   +1 more source