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Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study. [PDF]
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Mini-Reviews in Medicinal Chemistry, 2021
The current review discusses the different synthetic pathways for one of the most important and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers. Moreover,
Shubham, Khot +2 more
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The current review discusses the different synthetic pathways for one of the most important and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers. Moreover,
Shubham, Khot +2 more
openaire +3 more sources
1, 4‐Dihydropyridine mit Etacrynsäure‐Partialstruktur
Archiv der Pharmazie, 1992AbstractAusgehend von dem Acetophenon 3 werden über die Nitrobenzyliden‐Verbindungen 4 und 5 die 1,4‐Dihydropyridine (DHP) 6 und 7 mit einem Dichlorphenoxyessigsäure‐Substituenten hergestellt. Die DHP werden zu den Pyridinen 8 und 9 oxidiert. Bei der Bestrahlung des DHP 6a entsteht die cyclische Hydroxamsäure 10.
Klaus Görlitzer, Wolfgang Düwel
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N‐alkylation of 1, 4‐dihydropyridine derivatives
Bulletin des Sociétés Chimiques Belges, 1973AbstractA series of 1‐alkyl‐2, 6‐dimethyl‐3, 5‐diethoxycarbonyl‐4‐aryl‐1, 4‐dihydropyridines have been synthesised by the reaction of the corresponding 1, 4‐dihydro‐pyridines with consecutively sodium hydride and alkyl halides.
R. A. Dommisse, F. C. Alderweireldt
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Synthesis of 2,3-dihydrobenzofuran-3-spiro-4′-dihydropyridines
Tetrahedron Letters, 1981Abstract 2,3-Dihydrobenzofuran-3-spiro-4′-dihydropyridines are readily available via intramolecular addition of enolates to pyridinium ions.
Dwight D. Weller, Glenn R. Luellen
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Synthese et reaction de diacyl-1,4 alkyl-4 dihydropyridines
Tetrahedron, 1973Resume L'action du zinc et des anhydrides acetique, propionique et butyrique sur des pyridines substituees en C-4 donne des diacyl-1,4 alkyl-4 dihydropyridines, qui peuvent egalement etre obtenues par reaction radicalaire. L'acetyl-1 methylene-4 methyl-5 dihydro-4,5 azepine 24 a ete preparee par solvolyse du tosylate 23 , derivant de la diacetyl-1,
P.M. Atlani, J.F. Biellmann, J. Moron
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ChemInform Abstract: SYNTHESIS OF 2,3‐DIHYDROBENZOFURAN‐3‐SPIRO‐4′‐DIHYDROPYRIDINES
Chemischer Informationsdienst, 1982AbstractBei der Kondensation von Salicylaldehydmethylether (I) mit 2‐Acetyl‐furan (II) erhält man unter alkalischen Bedingungen das Diketon (III), das durch weitere Kondensation mit Hydroxylamin, anschließende Permanganatoxidation und Thermolyse über das Pyridin (IVa) und die Dicarbonsäure (IVb) zum Decarboxylierungsprodukt (IVc) führt.
D. D. WELLER, G. R. LUELLEN
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