Results 191 to 200 of about 85,474,312 (231)
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ChemInform Abstract: SYNTHESIS OF 2,3‐DIHYDROBENZOFURAN‐3‐SPIRO‐4′‐DIHYDROPYRIDINES
Chemischer Informationsdienst, 1982AbstractBei der Kondensation von Salicylaldehydmethylether (I) mit 2‐Acetyl‐furan (II) erhält man unter alkalischen Bedingungen das Diketon (III), das durch weitere Kondensation mit Hydroxylamin, anschließende Permanganatoxidation und Thermolyse über das Pyridin (IVa) und die Dicarbonsäure (IVb) zum Decarboxylierungsprodukt (IVc) führt.
D. D. WELLER, G. R. LUELLEN
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Synthese et reaction de diacyl-1,4 alkyl-4 dihydropyridines
Tetrahedron, 1973Resume L'action du zinc et des anhydrides acetique, propionique et butyrique sur des pyridines substituees en C-4 donne des diacyl-1,4 alkyl-4 dihydropyridines, qui peuvent egalement etre obtenues par reaction radicalaire. L'acetyl-1 methylene-4 methyl-5 dihydro-4,5 azepine 24 a ete preparee par solvolyse du tosylate 23 , derivant de la diacetyl-1,
P.M. Atlani, J.F. Biellmann, J. Moron
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Pflügers Archiv - European Journal of Physiology, 2003
Although often used as a Ca(2+) channel blocker, Mn(2+), in fact, permeates through Ca(2+) channels. Under Na(+)-free conditions, depolarizing pulses evoked slowly-decaying Mn(2+) currents ( I(Mn)). Maximal I(Mn) densities in the presence of 5 and 20 mM Mn(2+) were 0.42+/-0.12 pA/pF (mean+/-SEM, n=17) and 1.23+/-0.10 pA/pF ( n=40), respectively.
Haruko, Masumiya +3 more
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Although often used as a Ca(2+) channel blocker, Mn(2+), in fact, permeates through Ca(2+) channels. Under Na(+)-free conditions, depolarizing pulses evoked slowly-decaying Mn(2+) currents ( I(Mn)). Maximal I(Mn) densities in the presence of 5 and 20 mM Mn(2+) were 0.42+/-0.12 pA/pF (mean+/-SEM, n=17) and 1.23+/-0.10 pA/pF ( n=40), respectively.
Haruko, Masumiya +3 more
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Synthesis of 1, 4-Dihydropyridines using Different Nanocatalyst Systems
Research Journal of Chemistry and Environment1, 4-dihydropyridine (1, 4-DHP) is an important class of heterocyclic scaffold which possesses a wide variety of applications in biological and pharmacological field. In this review, we discuss the synthesis of 1, 4-dihydropyridine by using various nanocatalytic systems since 2010. Nanocatalyst provided efficient and green approach for the synthesis of
Deepak Babasaheb Phasage +2 more
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Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography
2005The chiral resolution of racemic drugs into their enantiomers is of great importance, because the two enantiomers often exhibit different pharmacological activity. This work deals with a group of very popular biologically active 1, 4-dihydropyridine drugs.
Litvić, Mladen, Vinković, Vladimir
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Synthesis of 3-cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thionks
Chemistry of Heterocyclic Compounds, 19833-Cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thiones have been synthesized for the first time by the condensation of arylideneacetophenones or 1-piperidino-1-phenyl-2-benzoylethane with cyanothioacetamide and the 1, 1-dicyano-2-aryl-3-benzoylpropane with hydrogen sulfide in the presence of bases. It has been established by PMR spectroscopy that 3-cyano-3,
A. A. Krauze +5 more
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Current Computer-Aided Drug Design, 2018
Tuberculosis is one of the main medical problems and some people are suffering still from this infectious disease. 1, 4-dihydropyridines are multi-target ligands that recently are recognized as anti-tubercular agents.In the current research, computational studies were conducted of some synthesized 1, 4- dihydropyridine-3, 5-dicarboxamides in non ...
Yasaman, Rasouli, Asghar, Davood
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Tuberculosis is one of the main medical problems and some people are suffering still from this infectious disease. 1, 4-dihydropyridines are multi-target ligands that recently are recognized as anti-tubercular agents.In the current research, computational studies were conducted of some synthesized 1, 4- dihydropyridine-3, 5-dicarboxamides in non ...
Yasaman, Rasouli, Asghar, Davood
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Enantioselective analysis of 1, 4-dihydropyridine drugs by luquid chromatography
2004The analyses for the following substances were performed: isradipine, nitrendipine, nicardipine, nisoldipine and felodipine. The most successful separations for the all investigated compounds were achieved on Chiralpak AD column that consist of amylose tris(3, 5-dimethylphenylcarbamat) as chiral selector.
Kalčić, Igor +2 more
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Synthesis and Biological Evaluation of New 1, 4-Dihydropyridines as Antihypertensives Agents in Rats
2003New analogues of nifedipine, as a known calcium channel blocker, were synthesized by replacing the orthonitrophenyl group on position 4 with 1-(4-Nitrobenzyl)-5-imidazolyl or 2methylthio-1-(4-Nitrobenzyl)-5-imidazolyl substituent. Effects of the new synthesized compounds on blood pressure were studied at 15, 30 and 60 min after administration by ...
Jorjani, M +5 more
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Aromatization of 1, 4-dihydropyridine derivatives
2006Pripravljeno je ukupno 29 različito supstituiranih 1, 4-dihidropiridinskih derivata korištenjem nekoliko varijanti Hantzschove kondenzacije. Prilikom pokušaja priprave derivata 35 sa prisutnom metoksi skupinom u ortho-položaju arilne grupe, korištenjem Hantzschove metode sa dva mola aminokrotonatnog estera, izoliran je literaturno novi spoj 49 kao ...
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