Results 161 to 170 of about 5,642 (192)

Synthesis of Multifunctionalized 2,3-Dihydro-4-pyridones and 4-Pyridones via the Reaction of Carbamoylated Enaminones with Aldehydes

The Journal of Organic Chemistry, 2018
The novel and effective diastereoselective synthesis of multifunctionalized dihydropyridones, including CF3-substituted derivatives, has been developed on the basis of the piperidine-promoted domino reaction of carbamoylated enaminones with aldehydes.
Dmitrii L. Obydennov, Asmaa I. El-Tantawy, Vyacheslav Y. Sosnovskikh   +2 more
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Two polymorphs of anhydrous 4-pyridone at 100 K

Acta Crystallographica Section C Crystal Structure Communications, 2008
Two polymorphs of the title compound, C(5)H(5)NO, (I), have been obtained from ethanol. One polymorph crystallizes in the monoclinic space group C2/c [henceforth (I)-M], while the other crystallizes in the orthorhombic space group Pbca [henceforth (I)-O]. In the two forms, the lattice parameters, cell volume and packing motifs are very similar.
Aleksandra, Tyl, Maria, Nowak, Joachim, Kusz   +2 more
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Potent antimalarial 4-pyridones with improved physico-chemical properties

Bioorganic & Medicinal Chemistry Letters, 2011
Antimalarial 4-pyridones are a novel class of inhibitors of the plasmodial mitochondrial electron transport chain targeting Cytochrome bc1 (complex III). In general, the most potent 4-pyridones are lipophilic molecules with poor solubility in aqueous media and low oral bioavailability in pre-clinical species from the solid dosage form.
José M, Bueno, Pilar, Manzano, María C, García, Jesús, Chicharro, Margarita, Puente, Milagros, Lorenzo, Adolfo, García, Santiago, Ferrer, Rubén M, Gómez, María T, Fraile, José L, Lavandera, José M, Fiandor, Jaume, Vidal, Esperanza, Herreros, Domingo, Gargallo-Viola   +14 more
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Preparation and antiinflammatory activity of 2- and 4-pyridones

Journal of Medicinal Chemistry, 1982
Several N-alkyl- and N-arylacetoacetamides have been self-condensed to form pyridones. N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoacetamides give 4-pyridones. In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.
J B, Pierce, Z S, Ariyan, G S, Ovenden
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Synthesis of 3-acetyl-2-amino-4-pyridone

Russian Chemical Bulletin, 1996
A method hxsynthesizing 3-acetyl-2-amino-4-pyyridone has been suggested. The synthesis involves the condensation of dimethylformamide dimethylacetal at the NH2 group of diphenylboron chelate diacetylketene aminal followed by its intramolecular cyclization under the action of NaOMe in MeOH.
V. A. Dorokhov, A. V. Komkov, A. M. Sakharo, V. S. Bogdanov   +3 more
openaire   +1 more source

Spectrofluorimetric determination of iridium(IV) traces using 4-pyridone derivatives

Talanta, 2004
A new spectrofluorimetric determination of iridium(IV) with 3-hydroxy-2-methyl-1-phenyl-4-pyridone (HX) or 3-hydroxy-2-methyl-1-(4-tolyl)-4-pyridone (HY) is reported. Iridium(IV) react with HX or HY and chelates were extracted into chloroform or dichloromethane. The organic phase showed fluorescence.
Miko, Slobodan, Vojković, Vlasta, Drušković Vukasović, Vinka   +2 more
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A facile synthesis of novel tricyclic 4-pyridones

Tetrahedron Letters, 2014
Abstract A new and efficient synthesis of tricyclic 4-pyridone analogs through the intramolecular Heck coupling cyclization was described. This reaction features mild conditions and good functional group tolerance allowing for the preparation of several novel tricyclic 4-pyridone analogs.
Buzhe Xu, Zhanling Cheng, Lei Fu
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Hydrogen bond–aromaticity cooperativity in self‐assembling 4‐pyridone chains

Journal of Computational Chemistry, 2015
Self‐assembling building blocks like the 4‐pyridone can exhibit extraordinary H‐bond‐aromaticity coupling effects. Computed dissected nucleus independent chemical shifts (NICS(1)zz), natural bond orbital (NBO) charges, and energy decomposition analyses (EDA) for a series of hydrogen (H‐) bonded 4‐pyridone chains (4‐py)n (n = 2 to 8) reveal that H ...
Megha, Anand, Israel, Fernández, Henry F, Schaefer, Judy I-Chia, Wu   +3 more
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ChemInform Abstract: Photochemical Cycloadditions to 5,6‐Dihydro‐4‐pyridones.

ChemInform, 1988
AbstractThe dihydropyridones (I) undergo photochemical (2 + 2) cycloaddition with dimethyl maleate (II) to give the cyclobutanes (III), whereas reaction with tetracyanoethylene (IV) forms the substitution products (V).
P. GUERRY, R. NEIER
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ChemInform Abstract: TRANSACYLATIONS WITH ACYL DERIVATIVES OF 4‐PYRIDONE

Chemischer Informationsdienst, 1980
AbstractMit den N‐Acylpyridonen (II) sowie mit 4‐Benzoyloxypyridin (III) werden die aliphatischen und aromatischen Amin (I) sowie Thiole (V) glatt zu den Amiden (IV) bzw. den Thioestern (VI) acyliert.
F. EFFENBERGER, E. BESSEY
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