Results 21 to 30 of about 5,642 (192)

Microbial−mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations [PDF]

, 2013
Understanding the metabolic processes associated with aging is key to developing effective management and treatment strategies for age-related diseases. We investigated the metabolic profiles associated with age in a Taiwanese and an American population.
Beckonert O., Bell J. D., Cannon J. G., Carmel R., Carol D. Ryff, Chadeau-Hyam M., Cho S., Christopher L. Coe, Clarke R., Coe C. L., Dana A. Glei, Davies K. M., Dean M., Elaine Holmes, Elsden S. R., Fukushima T., Goldman N., Hammar M. L., He F., Hebuterne X., Hehemann J. H., Holmes E., Hopkins M. J., Houtkooper R. H., Hurley B. F., Jeremy K. Nicholson, Jonathan R. Swann, Kaiser L. G., Kochhar S., Konstantina Spagou, Laidlaw S. A., Mariat D., Marmot M. G., Matthew Lewis, Maxine Weinstein, Mishur R. J., Muangpaisan W., Nicholson J. K., Noreen Goldman, Okuda Y., O’Sullivan O., Partridge L., Perrone R. D., Piper M. D., Psihogios N. G., Ramakrishna B. S., Ramakrishna B. S., Regitz-Zagrosek V., Robert L., Saude E. J., Slupsky C. M., Stanley E. G., Takiyama N., Teresa E. Seeman, Tiihonen K., Triantafyllou K., van den Bussche H., Veselkov K. A., Veselkov K. A., Vukovich M. D., Wald A., Walston J., Wang Y., Wang Z., Want E. J., Welshman S. G., Wijeyesekera A., Willets J. M., Williams A., Wolfe R. R., Yap I. K., Yasuda M., Zhang A. Q., Zhang F.   +73 more
core   +1 more source

Intra- and intermolecular proton transfer in 2,6-diaminopyridinium 4-hydroxypyridin-1-ium-2,6-dicarboxylate [PDF]

, 2012
Chelidamic acid (4-hydroxypyridine-2,6-dicarboxylic acid) and 2,6-diaminopyridine react to form the title salt, C5H8N3+·C7H4NO5-; there are two formula units in the asymmetric unit.
Bolte, Michael, Ton, Quoc-Cuong
core   +2 more sources

The Construction of Polycyclic Pyridones via Ring-Opening Transformations of 3-hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-diones

Molecules, 2023
This work describes the synthesis of 3-hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-diones, their tautomerism, and reactivity towards binucleophiles. These molecules are novel and convenient building-blocks for the direct construction of biologically
Viktoria V. Viktorova, Elena V. Steparuk, Dmitrii L. Obydennov, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +1 more source

Maternal Weaning Modulates Emotional Behavior and Regulates the Gut-Brain Axis. [PDF]

, 2016
Evidence shows that nutritional and environmental stress stimuli during postnatal period influence brain development and interactions between gut and brain.
A Osman, AM Myint, C Lino-de-Oliveira, CA Stockmeier, CS Carter, D Ben-Shachar, D Filliol, D Francis, D Keszthelyi, DF Gros, EW Alm, F Dieterle, I Lucki, ID Neumann, JA Bravo, JD Bell, JE LeDoux, JK Nicholson, JP Curley, K Ebner, Kitchen, KL Bales, KL Bales, KL Reichelt, L Desbonnet, L Desbonnet, LC Roger, LE Goehler, M Camilleri, M Detke, M Maes, M Maes, M Messaoudi, MM Palomar, MT Bailey, NJ Asha, P Bercik, P Bercik, P Zanos, P Zheng, PL Delgado, RD Heijtz, RD Porsolt, RJ Goody, SD Bilbo, SJ Henning, SJ Kitchen Slowe, SJ Lupien, SM Collins, SM O’mahony, SN Zheng, T Fukushima, T Fukushima, TA Clayton, Teschemacher Brantl, V Gigliucci, VT Ramaekers, XL Shu, Y Wang   +58 more
core   +1 more source

Catalytic asymmetric carbon-carbon bond forming methodologies for synthesis of chiral N-containing heterocycles and chiral carboxamides [PDF]

, 2020
In this thesis, we have developed several strategies that allow the Cu-catalyzed asymmetric conjugate addition of Grignard reagents to various heterocyclic substrates, such as 2- quinolones, 4-pyridone, 2,3-dihydro-4-pyridone, 2-quinolones and N ...
Guo, Yafei
core   +1 more source

Potential role of PIM1 inhibition in the treatment of SARS-CoV-2 infection

Journal of Genetic Engineering and Biotechnology, 2023
Background SARS-CoV-2 infection involves disturbing multiple molecular pathways related to immunity and cellular functions. PIM1 is a serine/threonine-protein kinase found to be involved in the pathogenesis of several viral infections. One PIM1 substrate,
Magda M. F. Ismail, Rehab R. El-Awady, Amal M. Farrag, Sara H. Mahmoud, Noura M. Abo Shama, Ahmed Mostafa, Mohamed A. Ali, Mohammed H. Rashed, Iman H. Ibrahim   +8 more
doaj   +1 more source

Reactions of Trifluorotriacetic Acid Lactone and Hexafluorodehydroacetic Acid with Amines: Synthesis of Trifluoromethylated 4-Pyridones and Aminoenones

Molecules, 2022
Dehydroacetic acid and triacetic acid lactone are known to be versatile substrates for the synthesis of a variety of azaheterocycles. However, their fluorinated analogs were poorly described in the literature.
Vladislav V. Fedin, Sergey A. Usachev, Dmitrii L. Obydennov, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +1 more source

A synthesis of 2,3-dihydro-4-pyridones [PDF]

Arkivoc, 2006
The reaction of 1-alkoxy-1,4-dien-3-ones with primary amines results in the formation of dihydropyridones in good yield.
Michael Harmata, Dong Reyoul Lee
openaire   +2 more sources

Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra [PDF]

, 2007
Population surveys for niacin deficiency are normally based on clinical signs or on biochemical measurements of urinary niacin metabolites. Status may also be determined by measurement of whole blood NAD and NADP concentrations. To compare these methods,
Cheung, E, Creeke, P I, Dibari, F, Kyroussis, E, Seal, A J, van den Briel, T   +5 more
core   +2 more sources

Crystal structure of N-[6-amino-5-(benzo[d]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C21H17N5O3S3·C3H7NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°.
Rasha A. Azzam, Galal H. Elgemeie, Rasha E. Elsayed, Peter G. Jones   +3 more
doaj   +1 more source