Results 61 to 70 of about 12,753,193 (203)

Two New Megastigmane Sulphonoglucosides from

Natural Product Communications, 2009
Phytochemical study of the methanol extract of Mallotus anisopodus led to the isolation of two new megastigmane sulphonoglucosides, namely anisoposides A (1) and B (2), along with junipetrioloside A (3), bergenin (4), α-tocopherol, and N 1 -methyl-2 ...
Chau Van Minh, Nguyen Thi Kim Thanh, Tran Hong Quang, Nguyen Xuan Cuong, Nguyen Nghia Thin, Nguyen Hoai Nam, Yvan Vander Heyden, Joëlle Quetin-Leclercq, Phan Van Kiem   +8 more
doaj   +1 more source

Domino-reactions of 3-methyl-5-aminopyrazole with 1-phenyl-3-(4-alkoxyphenyl)pyrazole-4-carbaldehydes and 2,2-dimethyl-1,3-dioxane-4,6-dione

Журнал органічної та фармацевтичної хімії, 2020
Aim. To synthesize 1-phenyl-3-(4-alkoxyphenyl)pyrazole-4-carbaldehydes and determine the direction of their interaction in the three-component condensation with 3-methyl-5-aminopyrazole and 2,2-dimethyl-1,3-dioxane-4,6-dione. Results and discussion. A
Olexander M. Semenenko, Victoria V. Lipson, Veronika V. Mironova, Lilia V. Budianska, Vladimir I. Musatov, Dmitro S. Sofronov   +5 more
doaj   +1 more source

Photochemical Cycloadditions to 5,6-Dihydro-4-pyridones

CHIMIA, 1987
5,6-Dihydro-4-pyridones (3a-3c) undergo photochemical [2 + 2]-cycloaddition with olefins activated by an electron withdrawing group. Alkyl substituted double bonds could only be brought to react in the intramolecular cases 3d and 3e.
Philippe Guerry, Reinhard Neier
openaire   +2 more sources

Dichlorido[1-(1,10-phenanthrolin-2-yl)-2-pyridone]cadmium(II)

Acta Crystallographica Section E, 2008
In the title mononuclear complex, [CdCl2(C17H11N3O)], the CdII ion assumes a distorted trigonal–bipyramidal coordination geometry. The pyridone plane is twisted out of the 1,10-phenanthroline mean plane by 43.8 (3)°.
Jin-Min Li
doaj   +1 more source

Design, Synthesis, In Silico Studies, and HIV‐1 RT Inhibitory Activity of 1,3‐Oxazolidine Pyrimidine Nucleoside Analogues

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Previously synthesized 1,3‐oxazolidine pyrimidine nucleoside analogues (S1–S6) were evaluated for HIV‐1 reverse transcriptase inhibition using molecular docking, ADMET prediction, and an in vitro colorimetric HIV‐RT assay. Compounds S4 and S5 exhibited the strongest binding affinities and moderate enzyme inhibition (IC50 = 19.27 and 22.80 µM ...
Shimoga Nagaraj Sriharsha, Zaid Mahmood Mohamed, Ammar A. Razzak Mahmood, Sibghatullah Muhammad Ali Sangi, Sadik Shaik, Sreeharsha Nagaraja, Sheeba Kumari, Vidhya Thirunavukkarasu, Pavan Kumar Sreenivasalu, Monirul Islam, Muhammad Shahzad Chohan, Mahalakshmi Suresha Biradar   +11 more
wiley   +1 more source

Ultrafast Decay Dynamics of the 2¹ππ* Electronic State of N‑Methyl-2-pyridone

The ultrafast decay dynamics of N-methyl-2-pyridone upon excitation in the near-ultraviolet range of 261.5–227.9 nm is investigated using the femtosecond time-resolved photoelectron spectroscopy method.
Wenping Wu (121781), Dongyuan Yang (8968340), Baihui Feng (17425266), Zhigang He (544691), Guorong Wu (307379), Xueming Yang (593735)   +5 more
core   +1 more source

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley   +1 more source

A novel, two-step synthesis of 4-pyridone-3-carboxamides from 2-cyano-4-pyrones [PDF]

, 2013
Reactions of 2-cyano-6-(trifluoromethyl)-4-pyrone, 2-cyano-4-pyrone, and 2-cyano-6-methyl-4-pyrone with aliphatic and aromatic amines in ethanol at -20 C for 2-21 days gave 5-amino-3-oxopent-4-enamides in 28-78% yields, which were cyclized with DMF-DMA ...
Obydennov, D. L., Sidorova, E. S., Usachev, B. I., Sosnovskikh, V. Y.   +3 more
core   +1 more source

Synthesis and Evaluation of Antitumor and Anti-Angiogenesis Activity of Pyrone- or Pyridone-Embedded Analogs of Cortistatin A

Marine Drugs
Simplified analogs of cortistatin A were synthesized and biologically evaluated to develop novel antitumor substances that target angiogenesis. To analyze the effect of substituents at positions corresponding to C-2 and/or C-4 of the A-ring, various ...
Yuri Fujimoto, Kanako Mizuno, Yuta Nakamura, Masayoshi Arai, Naoyuki Kotoku   +4 more
doaj   +1 more source

Synthesis, Characterization, and Biological Assessment of 2‐Methoxynicotinonitrile Derivatives

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
We report the synthesis of new 2‐methoxy‐3‐cyanopyridine derivatives via the nucleophilic aromatic substitution pathway, along with their crystal structure determination and preliminary biological evaluation. The new synthetic conversion described here demonstrates a practical method of preparing structurally diverse 2‐methoxy‐3‐cyanopyridines and ...
Eman Sulaiman, Eman Al‐Masri, Maram B. Alhawarri, Mohammad M. Ibrahim, Mahmoud Al‐Refai, Basem F. Ali, Ali Shuaib   +6 more
wiley   +1 more source