Results 71 to 80 of about 12,753,193 (203)

Biological evaluation of pyridone alkaloids on the endocannabinoid system [PDF]

, 2017
Naturally occurring pyridone alkaloids as well as synthetic derivatives were previously shown to induce neurite outgrowth. However, the molecular basis for this biological effect remains poorly understood.
Marck, Nicolas, Chicca, Andrea, Regina Berg, Burch, Patrick, Jessen, Henning J, Nicolas Marck, Jessen, Henning, Fabian Schmid, Patrick Burch, Gertsch, Jürg, Jürg Gertsch, Karl Gademann, Gademann, Karl, Berg, Regina, Henning J. Jessen, Andrea Chicca, Schmid, Fabian   +16 more
core   +2 more sources

New syntheses of 5,6- and 7,8-diaminoquinolines

Beilstein Journal of Organic Chemistry, 2013
The synthesis of 5,6- and 7,8-diaminoquinoline derivatives starting from angularly annelated selenadiazoloquinolones is presented. Simple chlorination of the pyridone ring followed by reductive deselenation of the 1,2,5-selenadiazole ring afforded novel ...
Maroš Bella, Viktor Milata
doaj   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1278-1290, September 2026.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Facile synthesis and cytotoxicity of substituted uracil-1'(N)-acetic acid and 4-pyridone-1'(N)-acetic acid esters of 20(S)-camptothecins

A series of novel substituted uracil-1'(N)-acetic acid esters (5–9) and 4-pyridone-1'(N)-acetic acid esters (10–11) of 20(S)-camptothecins (CPTs) have been synthesized by the acylation method.
Di-Zao Li (17955359), Zhao-Di Fu (17955362), Hong-Yan Liu (6290597), Xian-Dao Pan (17955365)   +3 more
core   +1 more source

Intramolecular Pyridone/Enyne Photocycloaddition: Partitioning of the [4 + 4] and [2 + 2] Pathways

, 2016
Intramolecular photocycloaddition (>290 nm) between a 1,3-enyne and a 2-pyridone is far more selective than the intermolecular version; a three-atom linkage both controls regiochemistry and separates the [2 + 2] and [4 + 4] pathways.
Scott McN. Sieburth (1538176), W. Scott Kassel (1409833), Michael J. Zdilla (1235907), William G. Dougherty (1645078), Svitlana Kulyk (1763944)   +4 more
core   +4 more sources

A New Convenient Synthesis of Functionalized 2,3‐Dihydro‐4‐pyridones.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Svetlik, Jan, Kettmann, Viktor, Zaleska, Barbara   +2 more
openaire   +2 more sources

Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles

Molecules, 2003
5-Nitro-2-pyridone can be selectively N-phenacylated, and the resulting phenacylpyridones I undergo cyclization to 6-nitrooxazolo[3,2-a]pyridinium salts II.
Eugene V. Babaev, Alexander A. Bush
doaj   +1 more source

Identification of New Anti‐Trypanosoma brucei Leads: An Integrated CRK12‐Guided Virtual Screen With Experimental Validation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Qin Li, Chenggong Fu, Jiayi Luo, Qianqian Zhang, Lingling Wang, Xiaomeng Liu, Jiayue Qiu, Xiaoqing Gong, Henry H. Y. Tong, Xiaojun Yao, Dehua Lai, Huanxiang Liu   +11 more
wiley   +1 more source

Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches

We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype.
Longo, Matteo, Radi, Marco, Giannessi, Lisa, Massera, Chiara   +3 more
core   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source