Results 91 to 100 of about 9,299,574 (208)

An unusual nicotinamide derivative, 4-pyridone-3-carboxamide ribonucleoside (4PYR), is a novel endothelial toxin and oncometabolite. [PDF]

Exp Mol Med, 2021
Mierzejewska P, Kunc M, Zabielska-Kaczorowska MA, Kutryb-Zajac B, Pelikant-Malecka I, Braczko A, Jablonska P, Romaszko P, Koszalka P, Szade J, Smolenski RT, Slominska EM.   +11 more
europepmc   +1 more source

Pyridone-based nucleotide analogues accepted for DNA biosynthesis

, 2017
Novel pyridone-based nucleotides were investigated for maintenance of DNA synthesis, carried on by representatives of different classes of polymerases. Five different nucleoside triphosphates of similar structure were addressed, demonstrating involvement
Bazilė Ravoitytė, Algirdas Mikalkėnas, Daiva Tauraitė, Saulius Serva   +3 more
core   +1 more source

Examining the safety of nicotinamide for skin cancer prevention: Review of adverse events, metabolism, and toxic dosages

JAAD Reviews
Nicotinamide (niacinamide) supplementation for non-melanoma skin cancer prevention has sparked controversy over the past decade due to its inconsistent evidence of chemoprevention and its recently challenged safety profile.
Katie R. Xu, BA, Micah Belzberg, MD, Allison T. Vidimos, MD, RPh   +2 more
doaj   +1 more source

Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae

Parasites & Vectors, 2014
Background The African malaria vector, Anopheles gambiae s.s., is known to feed selectively on certain plants for sugar sources. However, the adaptive significance of this behaviour especially on how the extracts of such plants impact on the fitness of ...
Sabina Wangui Wachira, Sabar Omar, Julia Wanjiru Jacob, Martin Wahome, Hans T Alborn, David R Spring, Daniel K Masiga, Baldwyn Torto   +7 more
doaj   +1 more source

Biofilm-specific uptake of a 4-pyridone-based iron chelator by Pseudomonas aeruginosa. [PDF]

Biometals, 2021
Houshmandyar S, Eggleston IM, Bolhuis A.
europepmc   +1 more source

4-Pyridone-3-carboxamide-1-β-d-ribonucleoside Triphosphate (4PyTP), a Novel NAD+ Metabolite Accumulating in Erythrocytes of Uremic Children: A Biomarker for a Toxic NAD+ Analogue in Other Tissues?

Toxins, 2011
We have identified a novel nucleotide, 4-pyridone 3/5-carboxamide ribonucleoside triphosphate (4PyTP), which accumulates in human erythrocytes during renal failure.
Elizabeth A. Carrey, Ryszard T. Smolenski, H. Anne Simmonds, Ewa M. Slominska, Lynnette D. Fairbanks, Elena Synesiou   +5 more
doaj   +1 more source

Well isolated copper(II) pyrazine-bridged chains: synthesis and magneto-structural analysis of 2-halo-4-pyridone perchlorate complexes

Two new coordination polymers, [Cu(pz)(L)2(H2O)2](ClO4)2 (L = 2-Cl- (1) or 2-Br-4-pyridone (2); pz = pyrazine), have been synthesized and characterized by X-ray diffraction, EPR and variable temperature magnetic measurements.
Jeffrey C. Monroe (5673371), Jan L. Wikaira (2078116), Christopher P. Landee (2078104), Mark M. Turnbull (1556680)   +3 more
core   +2 more sources

Pyridone-substituted Pyridyl imines as Functionalised ligands in Coordination Chemistry and Catalysis

, 2018
In this thesis, the synthesis and coordination chemistry of a series of novel NNN and NN proton responsive ligands are described. All the ligands and complexes have been characterized by a combination of multinuclear NMR spectroscopic techniques, mass ...
Mona Hanash A. Alhalafi (7716149)
core   +1 more source

Chemistry of Nitroquinolones and Synthetic Application to Unnatural 1-Methyl-2-quinolone Derivatives

Molecules, 2010
The 1-methyl-2-quinolone (MeQone) framework is often found in alkaloids and recently attention was drawn to unnatural MeQone derivatives with the aim of finding new biologically active compounds, however, low reactivity of the MeQone framework prevents ...
Nagatoshi Nishiwaki
doaj   +1 more source

Studies on 4-Pyrones and 4-Pyridones. I. The Preparation of 1-Aryl-3-hydroxy-4-pyridones and Related Compounds

Croatica Chemica Acta, 1962
By condensation rnf meconic acid, comenic acid, or comenic acid methyl ether with primary aromatic amines, 1-aryl-5-hydroxy-4- -pyridone-2-carboxylic acids, or their methyl ethers, were obtained with satisfactory yields. Decarboxylation of the acids yielded 1-aryl-3-hydroxy-4-pyridones or the corresponding 1-aryl-3- -methoxy-4-pyridones.
Hahn, V., Kukolja, S.
openaire   +2 more sources