Results 211 to 220 of about 11,679,551 (275)

Eco-friendly decarboxylative cyclization in water: practical access to the anti-malarial 4-quinolones

Green Chemistry, 2019
An eco-friendly decaboxylative cyclization in water has been developed to construct 4-quinolones from readily available isatoic anhydrides and 1,3-dicarbonyl compounds.
Yue Ma, Yongping Zhu, Dong Zhang, Yuqing Meng, T. Tang, Kun Wang, Ji Ma, Jigang Wang, Peng Sun   +8 more
semanticscholar   +1 more source

4-Quinolones and the SOS response

Journal of Medical Microbiology, 1989
The SOS DNA repair system is induced in bacteria treated with 4-quinolones. However, whether the response exacerbates or repairs the damage caused by these drugs is still unclear. The recA13 and the recB21 mutations impair recombination repair and render bacteria unable to induce the SOS response when treated with nalidixic acid or other agents that ...
C S, Lewin, B M, Howard, N T, Ratcliffe, J T, Smith   +3 more
openaire   +2 more sources

Rhodium(iii)-catalyzed [3 + 3] annulation reactions of N-nitrosoanilines and cyclopropenones: an approach to functionalized 4-quinolones

Organic Chemistry Frontiers, 2019
We report Rh(iii)-catalyzed [3 + 3] annulation reactions for the preparation of functionalized 4-quinolones from available N-nitrosoanilines and cyclopropenones.
Yafeng Liu, Yuan Tian, Kexin Su, Peigen Wang, Xin Guo, Baohua Chen   +5 more
semanticscholar   +1 more source

Comparative Activity of the 4-Quinolones

Clinical Infectious Diseases, 1988
Minimal inhibitory concentrations (MICs) of the 4-quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin, difloxacin, A-56620, and CI-934 are consistent world-wide, with allowances for differences in acquired resistance. MICs of these drugs for Enterobacteriaceae correlate with those of nalidixic acid, but resistance to the quinolones ...
I, Phillips, A, King
openaire   +2 more sources

Metal-Free Synthesis of 3-(Iso)quinolinyl 4-Chromenones and 3-(Iso)quinolinyl 4-Quinolones from (Iso)quinoline N-Oxides and Ynones.

Organic Letters, 2019
A general approach for the synthesis of 3-(iso)quinolinyl 4-chromenones and 3-(iso)quinolinyl 4-quinolones from (iso)quinoline N-oxides and ynones under metal-free conditions was developed.
Shantong Zhang, Chunlin Wu, Zunting Zhang, Tao Wang   +3 more
semanticscholar   +1 more source

4-quinolones inhibit biotransformation of caffeine

European Journal of Clinical Pharmacology, 1988
The pharmacokinetics of caffeine, including formation of its major metabolite paraxanthine in plasma, has been investigated in 12 healthy males (age 20-40 years) alone and during co-administration of the 4-quinolones ofloxacin, norfloxacin, pipemidic acid, ciprofloxacin, and enoxacin; ciprofloxacin and enoxacin were given in 3 different dose levels ...
S, Harder, A H, Staib, C, Beer, A, Papenburg, W, Stille, P M, Shah   +5 more
openaire   +2 more sources

New Balfourodendron 4-quinolone alkaloids

Tetrahedron, 1973
Abstract New tertiary alkaloids with a 4-quinolone skeleton, (±)-ribalinine ( 3b ), (−)-ribalinidine ( 3c ), (±) and (+)-ribaline ( 2b ), have been obtained from Balfourodendron riedelianum . During isolation, 3c and 3b were found together with the quaternary alkaloidal fraction.
R.A. Corral, O.O. Orazi, I.A. Benages
openaire   +1 more source

Recent Advances in the Assembly of Organoselenyl‐Substituted (Thio)Chromones and 4‐Quinolones

Advanced Synthesis & Catalysis
Organoselenylated chromones, thiochromones, and 4‐quinolones, as an important members of selenyl‐bearing heterocycles, present significant biological activities.
Jinhui Cai, Zhouting Zeng, Qiaolin Wang, Weishuang Li   +3 more
semanticscholar   +1 more source

Switchable Access to 3-Carboxylate-4-quinolones and 1-Vinyl-3-carboxylate-4-quinolones via Oxidative Cyclization of Isatins and Alkynes.

Organic Letters, 2018
An efficient transition-metal-free oxidative cyclization reaction using isatins and alkynes for the facile synthesis of structurally diverse 4-quinolones has been developed.
Shi-Fen Jiang, Cheng Xu, Zhi-Wen Zhou, Qin Zhang, Xiao-Hui Wen, Fengcheng Jia, A. Wu   +6 more
semanticscholar   +1 more source

Structural assignment of the enol–keto tautomers of one-pot synthesized 4-hydroxyquinolines/4-quinolones

Organic Chemistry Frontiers, 2019
The one-pot preparation of 2,3-disubstituted 4-quinolones and the structural assignment of their tautomers are described.
O. Kang, Seonghwal Park, H. Ahn, K. Jeong, H. Lim   +4 more
semanticscholar   +1 more source