Results 221 to 230 of about 11,679,551 (275)
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Gold-catalyzed cyclization of 1-(2'-azidoaryl) propynols: synthesis of polysubstituted 4-quinolones.
Chemical Communications, 2019An unprecedented gold-catalyzed procedure for the synthesis of polysubstituted 4-quinolones from 1-(2'-azidoaryl) propynols is described. The reaction undergoes an intramolecular nucleophilic attack of the azide group to the Au-activated triple bonds in ...
Xiang Wu +4 more
semanticscholar +1 more source
4-Quinolone hybrids and their antibacterial activities
European Journal of Medicinal Chemistry, 2017The emergence and wide-spread of drug-resistant bacteria including multi-drug resistant and pan-drug resistant pathogens which are associated with considerable mortality, represent a significant global health threat. 4-Quinolones which are exemplified by fluoroquinolones are the second largest chemotherapy agents used in clinical practice for the ...
Yuan-Qiang, Hu +5 more
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Methods of analysis of 4-quinolone antibacterials
Talanta, 1999A comprehensive review with 270 references for the analysis of the members of an important class of drugs, 4-quinolone antibacterials, is presented. The review covers most of the methods described for the analysis of these drugs either per se, in dosage forms or in biological fluids.
F, Belal, A A, Al-Majed, A M, Al-Obaid
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ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
E. J. BEHRMAN +4 more
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
E. J. BEHRMAN +4 more
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Archives of Pharmacal Research, 1998
A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor, antiherpes and antituberculosis activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (IC50 = 17.7 microM for HL60) which was greater than that of acronycine ...
M W, Chun +6 more
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A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor, antiherpes and antituberculosis activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (IC50 = 17.7 microM for HL60) which was greater than that of acronycine ...
M W, Chun +6 more
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Mutational Resistance to 4-Quinolone Antibacterial Agents
European Journal of Clinical Microbiology, 1984The activity of ten 4-quinolone drugs was tested against five Escherichia coli mutants. Mutational resistance was found to reduce the activity of all ten drugs, indicating that they display biochemical cross-resistance with each other. However, ciprofloxacin and, to a lesser extent, ofloxacin and norfloxacin were so highly active that the most ...
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4-Quinolone bactericidal mechanisms.
Arzneimittel-Forschung, 1994The bactericidal activity of nalidixic acid against Escherichia coli strain KL16 in nutrient broth was abolished by the addition of rifampicin. Cells suspended in phosphate-buffered normal saline (PBS) were also not killed by nalidixic acid. Experiments with modern 4-quinolones showed their activities varied according to the conditions under which they
B M, Howard, R J, Pinney, J T, Smith
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Detection of 2-Alkyl-4-Quinolones Using Biosensors
20102-alkyl-4-quinolones (AQs) such as 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-quinolone (HHQ) are quorum sensing signal molecules. Here we describe two methods for AQ detection and quantification that employ thin layer chromatography (TLC) and microtitre plate assays in combination with a lux-based Pseudomonas aeruginosa AQ biosensor strain ...
Matthew P, Fletcher +3 more
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Pharmacokinetics of Fluorinated 4-Quinolones in the Aged
Clinical Infectious Diseases, 1989Differences between the pharmacokinetics of the new fluoroquinolones in the young and in the elderly have been demonstrated for ciprofloxacin, enoxacin, norfloxacin, and ofloxacin. Comparative studies of the young and the elderly are still lacking for pefloxacin.
S R, Norrby, B, Ljungberg
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Malatyamine, A 4-Quinolone Alkaloid from Haplophyllum cappadocicum
Journal of Natural Products, 1985[No abstract available]
GöZler T. +3 more
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