Results 231 to 240 of about 11,679,551 (275)

Membrane permeability of Pseudomonas aeruginosa to 4-quinolones

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology, 1987
The outer membrane-disorganizing agent polymyxin B nonapeptide sensitized Pseudomonas aeruginosa strains 2-40fold to ciprofloxacin, norfloxacin, and ofloxacin, and 80-200fold to nalidixic acid. Sensitized P. aeruginosa strains were nearly as susceptible to nalidixic acid as Escherichia coli strains. The data suggest that the outer membrane permeability
P, Kubesch, M, Wehsling, B, Tümmler
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4-Quinolone interactions with gyrase subunit B inhibitors

Journal of Medical Microbiology, 1991
In studies which have involved determination of fractional inhibitory concentrations, synergy has been described between the 4-quinolones, which inhibit the A subunit of DNA gyrase, and either coumermycin or novobiocin, which inhibit the B subunit of the same enzyme.
C S, Lewin, B M, Howard, J T, Smith
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Mechanisms of Resistance to 4-Quinolones

1990
With expanding clinical use of the 4-quinolone antibacterial agents, resistance to these agents has been identified (Wolfson and Hooper 1989a,b), and its mechanisms have been the subject of increasing study. In this article we review the current information on the mechanisms of bacterial resistance to 4-quinolones.
D. C. Hooper, J. S. Wolfson
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Reactivity of 3-Iodo-4-quinolones in Heck Reactions: Synthesis of Novel (E)-3-Styryl-4-quinolones

Synlett, 2010
A new and efficient route for the synthesis of (E)-N-methyl-3-styryl-4-quinolones is described. It involves the Heck reaction of N-methyl-3-iodo-4-quinolone, which is obtained by consecutive 3-iodination and NH-methylation of the unsubstituted 4-quinolone, with styrene derivatives.
Artur Silva, Andreia Almeida, José Cavaleiro   +2 more
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Recent methods of 4-quinolone synthesis (microreview)

Chemistry of Heterocyclic Compounds, 2018
This microreview is devoted to recently reported methods for the synthesis of 4-quinolones including activated alkyne-based reactions, K2CO3/DIPEA-catalyzed reaction, Baylis–Hillman reaction, Pd-catalyzed Buchwald–Hartwig amination, intramolecular Houben–Hoesch reaction, tandem acyl transfer – cyclization of o-alkynoylanilines, fused heterocycle ...
Seyed Sajad Sajadikhah, Nesa Lotfifar
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The 4‐Quinolone Antibiotics: Past, Present, and Future

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1988
During the past 5 years the 4‐quinolone antibiotics have progressed from relative obscurity to a highly visible and intensely studied class of compounds. The zeal for developing and marketing newer fluoroquinolones closely parallels that of the cephalosporins for the last 10 years.
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Clinical Pharmacokinetics of the Newer Antibacterial 4-Quinolones

Clinical Pharmacokinetics, 1988
Structural modification of the so-called 'first-generation' or 'urinary' quinolones has led to a considerable increase in their intrinsic antibacterial activity, together with marked changes in the pharmacokinetic properties. Tissue penetration is the most notable change, and the newer quinolones are comparable with the newer broad spectrum beta ...
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4-Quinolone resistant staphylococci

Journal of Antimicrobial Chemotherapy, 1990
M S, Dryden, H A, Ludlam, I, Phillips
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Cobalt(III)- and Rhodium(III)-Catalyzed C-H Amidation and Synthesis of 4-Quinolones: C-H Activation Assisted by Weakly Coordinating and Functionalizable Enaminone.

Organic Letters, 2017
Fen Wang, Liang Jin, Lingheng Kong, Xingwei Li   +3 more
semanticscholar   +1 more source

Mutation rates to 4-quinolone resistance.

Arzneimittel-Forschung, 1990
The sensitivity of Staph. aureus, Staph. warneri, Pseudomonas aeruginosa, Strep. pneumoneae and Strep. faecalis to eleven 4-quinolone antibacterials was compared by determining their minimum inhibitory concentrations on nutrient agar. In all cases where the minimum inhibitory concentration was less than 10 micrograms/ml then the frequency at which 4 ...
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