Results 261 to 270 of about 32,766 (293)
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Infection Control, 1987
AbstractImprovements in antimicrobial activity and pharmacokinetics have moved the 4-quinolones into the forefront of antibiotic research. The 4-quinolones are analogues of nalidixic acid, and there are presently at least six agents in this group under investigation in the United States.
Mark Eggleston, Soon-Young Park
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AbstractImprovements in antimicrobial activity and pharmacokinetics have moved the 4-quinolones into the forefront of antibiotic research. The 4-quinolones are analogues of nalidixic acid, and there are presently at least six agents in this group under investigation in the United States.
Mark Eggleston, Soon-Young Park
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4-Quinolones and the SOS response
Journal of Medical Microbiology, 1989The SOS DNA repair system is induced in bacteria treated with 4-quinolones. However, whether the response exacerbates or repairs the damage caused by these drugs is still unclear. The recA13 and the recB21 mutations impair recombination repair and render bacteria unable to induce the SOS response when treated with nalidixic acid or other agents that ...
B. M. A. Howard +3 more
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Comparative Activity of the 4-Quinolones
Clinical Infectious Diseases, 1988Minimal inhibitory concentrations (MICs) of the 4-quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin, difloxacin, A-56620, and CI-934 are consistent world-wide, with allowances for differences in acquired resistance. MICs of these drugs for Enterobacteriaceae correlate with those of nalidixic acid, but resistance to the quinolones ...
Ian Phillips, Anna King
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Pharmacokinetics of Fluorinated 4-Quinolones in the Aged
Clinical Infectious Diseases, 1989Differences between the pharmacokinetics of the new fluoroquinolones in the young and in the elderly have been demonstrated for ciprofloxacin, enoxacin, norfloxacin, and ofloxacin. Comparative studies of the young and the elderly are still lacking for pefloxacin.
Bengt Ljungberg, S. Ragnar Norrby
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4-Quinolone hybrids and their antibacterial activities
European Journal of Medicinal Chemistry, 2017The emergence and wide-spread of drug-resistant bacteria including multi-drug resistant and pan-drug resistant pathogens which are associated with considerable mortality, represent a significant global health threat. 4-Quinolones which are exemplified by fluoroquinolones are the second largest chemotherapy agents used in clinical practice for the ...
Lian-Shun Feng +5 more
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4-quinolones inhibit biotransformation of caffeine
European Journal of Clinical Pharmacology, 1988The pharmacokinetics of caffeine, including formation of its major metabolite paraxanthine in plasma, has been investigated in 12 healthy males (age 20-40 years) alone and during co-administration of the 4-quinolones ofloxacin, norfloxacin, pipemidic acid, ciprofloxacin, and enoxacin; ciprofloxacin and enoxacin were given in 3 different dose levels ...
P M Shah +5 more
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Methods of analysis of 4-quinolone antibacterials
Talanta, 1999A comprehensive review with 270 references for the analysis of the members of an important class of drugs, 4-quinolone antibacterials, is presented. The review covers most of the methods described for the analysis of these drugs either per se, in dosage forms or in biological fluids.
Fathalla Belal +2 more
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ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Edward J. Behrman +4 more
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Edward J. Behrman +4 more
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Mutational Resistance to 4-Quinolone Antibacterial Agents [PDF]
European Journal of Clinical Microbiology, 1984 The activity of ten 4-quinolone drugs was tested against five Escherichia coli mutants. Mutational resistance was found to reduce the activity of all ten drugs, indicating that they display biochemical cross-resistance with each other. However, ciprofloxacin and, to a lesser extent, ofloxacin and norfloxacin were so highly active that the most ...
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