Results 271 to 280 of about 32,766 (293)
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Archives of Pharmacal Research, 1998
A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor, antiherpes and antituberculosis activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (IC50 = 17.7 microM for HL60) which was greater than that of acronycine ...
Chong-Kyo Lee +6 more
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A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor, antiherpes and antituberculosis activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (IC50 = 17.7 microM for HL60) which was greater than that of acronycine ...
Chong-Kyo Lee +6 more
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New Balfourodendron 4-quinolone alkaloids
Tetrahedron, 1973Abstract New tertiary alkaloids with a 4-quinolone skeleton, (±)-ribalinine ( 3b ), (−)-ribalinidine ( 3c ), (±) and (+)-ribaline ( 2b ), have been obtained from Balfourodendron riedelianum . During isolation, 3c and 3b were found together with the quaternary alkaloidal fraction.
Renée A. Corral +2 more
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Mechanisms of Resistance to 4-Quinolones
1990With expanding clinical use of the 4-quinolone antibacterial agents, resistance to these agents has been identified (Wolfson and Hooper 1989a,b), and its mechanisms have been the subject of increasing study. In this article we review the current information on the mechanisms of bacterial resistance to 4-quinolones.
D. C. Hooper, J. S. Wolfson
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3 4-Quinolones as Potential Cardiovascular Agents
1995Publisher Summary This chapter focuses on 4-Quinolones as potential cardiovascular agents. Cardiovascular diseases continue to be the focus of considerable attention from the pharmaceutical industry. Prevalence of the disease is high in Western society and, despite publicity surrounding healthier lifestyles, is likely to continue to be a problem. The
Davies Roy Victor, Yates David Bryan
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DNA gyrase, topoisomerase IV, and the 4-quinolones
Microbiology and Molecular Biology Reviews, 1997For many years, DNA gyrase was thought to be responsible both for unlinking replicated daughter chromosomes and for controlling negative superhelical tension in bacterial DNA. However, in 1990 a homolog of gyrase, topoisomerase IV, that had a potent decatenating activity was discovered.
Xilin Zhao, Karl Drlica
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Mechanisms of Killing of Bacteria by 4-Quinolones [PDF]
, 1990 The 4-quinolones are a major new class of potent orally-absorbed antibacterial agents. These drugs, derivatives of the earlier marketed drugs nalidixic acid and oxolinic acid, include norfloxacin, ciprofloxacin, ofloxacin, fleroxacin, lomefloxacin, temafloxacin, spafloxacin, and others.
J. S. Wolfson, D. C. Hooper
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Induction of the SOS response by new 4-quinolones
Journal of Antimicrobial Chemotherapy, 1987The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing ...
Felipe Moreno +3 more
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Membrane permeability of Pseudomonas aeruginosa to 4-quinolones
Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology, 1987The outer membrane-disorganizing agent polymyxin B nonapeptide sensitized Pseudomonas aeruginosa strains 2-40fold to ciprofloxacin, norfloxacin, and ofloxacin, and 80-200fold to nalidixic acid. Sensitized P. aeruginosa strains were nearly as susceptible to nalidixic acid as Escherichia coli strains. The data suggest that the outer membrane permeability
Burkhard Tümmler +2 more
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ChemInform Abstract: Conversion of a 4‐Quinolone into a 1,6‐Diazaphenalene.
ChemInform, 1997AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mercedes Alvarez +3 more
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ChemInform Abstract: Synthesis of 4‐Quinolone Derivatives.
ChemInform, 1995AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
K. B. G. Torssell, S. Jensen
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