Results 281 to 290 of about 32,766 (293)

Detection of 2-Alkyl-4-Quinolones Using Biosensors

2010
2-alkyl-4-quinolones (AQs) such as 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-quinolone (HHQ) are quorum sensing signal molecules. Here we describe two methods for AQ detection and quantification that employ thin layer chromatography (TLC) and microtitre plate assays in combination with a lux-based Pseudomonas aeruginosa AQ biosensor strain ...
Miguel Cámara, Matthew P. Fletcher, Stephen P. Diggle, Paul Williams   +3 more
openaire   +4 more sources

Mechanisms of resistance to the 4-quinolone antibacterial agents

Journal of Antimicrobial Chemotherapy, 1990
Because of the close structural relationship of the fluorinated 4-quinolones to the parent compound nalidixic acid the mechanism of resistance is often perceived to be the same. However, it is clear that whilst the mechanism of resistance to fluorinated 4-quinolones is essentially the same, strains that are selected as resistant to nalidixic acid ...
openaire   +3 more sources

Cycloaddition reactions of N-alkoxycarbonyl-4-quinolones

Tetrahedron, 1989
AbstractIn connection with the search for anthracycline analogues which retain the cytotoxicity but possess negligible cardiotoxicity, structures modified in ring C to give non‐reducible analogues of anthracyclines are required.
John R Nicholson, Kevin J. McCullough, Gurdial Singh, Richard H. Wightman   +3 more
openaire   +3 more sources

ChemInform Abstract: An Efficient Synthesis of Di‐ and Trimethoxy‐4‐quinolones.

ChemInform, 1994
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. Negishi, Y. Horiguchi, T. Fuse, Takehiro Sano, N. Ando, J. Toda, E. Kishikawa   +6 more
openaire   +3 more sources

The 4‐Quinolone Antibiotics: Past, Present, and Future

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1988
During the past 5 years the 4‐quinolone antibiotics have progressed from relative obscurity to a highly visible and intensely studied class of compounds. The zeal for developing and marketing newer fluoroquinolones closely parallels that of the cephalosporins for the last 10 years.
openaire   +3 more sources

Clinical Pharmacokinetics of the Newer Antibacterial 4-Quinolones

Clinical Pharmacokinetics, 1988
Structural modification of the so-called 'first-generation' or 'urinary' quinolones has led to a considerable increase in their intrinsic antibacterial activity, together with marked changes in the pharmacokinetic properties. Tissue penetration is the most notable change, and the newer quinolones are comparable with the newer broad spectrum beta ...
openaire   +3 more sources

4-Quinolone resistant staphylococci

Journal of Antimicrobial Chemotherapy, 1990
Ian Phillips, M. S. Dryden, H. A. Ludlam
openaire   +3 more sources

The antibacterial action of the 4-quinolones

Antimicrobic Newsletter, 1985
L.J.V Piddock, R Wise
openaire   +2 more sources

Pd-Catalyzed Synthesis of 4-Quinolones [PDF]

Synfacts, 2008
A. O. King, Robert D. Larsen, Y. Chen, Margaret M. Faul, J. Huang, M. Dilmeghani   +5 more
openaire   +1 more source

164. The bromination of some 4-quinolones

Journal of the Chemical Society (Resumed), 1939
S. G. P. Plant, H. P. W. Huggill
openaire   +2 more sources