Results 51 to 60 of about 34,010 (190)

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Evaluation of antibacterial activity of new N-piperazinyl quinolone derivatives with 1,3,4.thiadiazole group [PDF]

Journal of Kerman University of Medical Sciences, 2001
quinolones are broad-spectrum antibacterial agents.they have many clinical uses which are increasing.quinolones exert antibacterial activity primarily by inhibiting bacterial DNA gyrase.the inhibition of DNA gyrase by the quinolones are greatly ...
M.H Moshafi, A.R Foromadi, M Rajaei
doaj  

Resistance pattern of enterobacteriaceae isolates from urinary tract infections to selected quinolones in Yaoundé

The Pan African Medical Journal, 2015
INTRODUCTION: it is estimated that 150 million urinary tract infections (UTIs) occur yearly worldwide, resulting in more than 6 billion dollar in direct healthcare cost.
Emilia Enjema Lyonga, Michel Toukam, Celine Nkenfou, Hortense Kamga Gonsu, Marie-Claire Okomo Assoumou, Martha Tongo Mesembe, Agnes Bedie Eyoh, George Mondinde Ikomey, Valantine Ngum Ndze, Sinata Koulla-Shiro   +9 more
doaj   +1 more source

Analytical profiling of mutations in quinolone resistance determining region of gyrA gene among UPEC. [PDF]

PLoS ONE, 2018
Mutations in gyrA are the primary cause of quinolone resistance encountered in gram-negative clinical isolates. The prospect of this work was to analyze the role of gyrA mutations in eliciting high quinolone resistance in uropathogenic E.coli (UPEC ...
Lesley R Varughese, Meenakshi Rajpoot, Soniya Goyal, Ravinder Mehra, Vinod Chhokar, Vikas Beniwal   +5 more
doaj   +1 more source

Usual and unusual antibacterial effects of quinolones [PDF]

, 2017
Recently documented antibacterial effects of quinolones are reviewed. DNA gyrase is most likely to be the primary target site for these agents. Quinolones rapidly kill susceptible bacteria; the mechanisms of the bactericidal activity, still poorly ...
Furet, Y. X., Pechère, J.-C
core  

Mechanistic elucidation of HFIP‐enabled C–Cl bond activation in the synthesis of tetrahydroquinoline derivatives

Bulletin of the Korean Chemical Society, EarlyView.
Mechanistic studies reveal that hexafluoroisopropanol (HFIP) enables C–Cl activation of propargylic halides by stabilizing ion pairs and enhancing effective Brønsted acidity. This cooperative solvent effect allows access to cationic intermediates and promotes cascade formation of tetrahydroquinolines through cyclization and disproportionation ...
Seung Hoon Lee, Hyung Min Chi
wiley   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, EarlyView.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Bacterial cell-to-cell signaling promotes the evolution of resistance to parasitic bacteriophages [PDF]

, 2017
The evolution of host–parasite interactions could be affected by intraspecies variation between different host and parasite genotypes. Here we studied how bacterial host cell-to-cell signaling affects the interaction with parasites using two bacteria ...
Allen, Betts, Dandekar, Darch, Davies, De Smet, Diggle, Diggle, Friman, Friman, Glessner, Harrison, Hosseinidoust, Hoyland-Kroghsbo, James, Jousset, Korgaonkar, Latifi, Lively, Lopez-Medina, Lopez-Pascua, McKnight, Merabishvili, Michelsen, Mumford, Schuster, Schuster, Sorci, Tan, Thompson, Vrijenhoek, Waters, West, Wilder, Williams, Yosef   +35 more
core   +1 more source

Dearomatization with Axial‐to‐Central Chirality Conversion

European Journal of Organic Chemistry, EarlyView.
Atropisomers are exciting synthetic targets with unique properties, which find applications in many fields of chemistry. However, considering them as substrates is not very frequent, notably in the context of dearomatization reaction. We wish to discuss the different strategies for the dearomatization of aromatic atropisomers with axial‐to‐central ...
Morgane Mando, Clément Lemaitre, Thierry Constantieux, Xavier Bugaut   +3 more
wiley   +1 more source

Designing a single-molecule biophysics tool for characterizing DNA damage for techniques that kill infectious pathogens through DNA damage effects [PDF]

, 2016
Antibiotics such as the quinolones and fluoroquinolones kill bacterial pathogens ultimately through DNA damage. They target the essential type IIA topoisomerases in bacteria by stabilising the normally transient double strand break state which is created
Leake, Mark Christian, Miller, Helen Louise, Wollman, Adam   +2 more
core   +2 more sources