Synthetic approach to 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides based on common β-keto amide precursors [PDF]
Beilstein Journal of Organic Chemistry, 2023 β-Keto amides were used as convenient precursors to both 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides. The utility of this approach is demonstrated with the synthesis of fourteen novel and four known quinolone derivatives, including ...
Yordanka Mollova-Sapundzhieva +3 more
doaj +2 more sources
Enhanced Selectivity in 4-Quinolone Formation: A Dual-Base System for Palladium-Catalyzed Carbonylative Cyclization with Fe(CO)5 [PDF]
MoleculesThe use of gaseous CO in Pd-catalyzed carbonylative quinolone synthesis presents challenges related to safety and precise pressure control. In response, a streamlined non-gaseous synthesis of 4-quinolone compounds has been developed.
Meng Guo +5 more
doaj +2 more sources
Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR). [PDF]
PLoS Pathogens, 2013 Bacterial populations co-ordinate gene expression collectively through quorum sensing (QS), a cell-to-cell communication mechanism employing diffusible signal molecules.
Aravindan Ilangovan +10 more
doaj +6 more sources
A bacterial quorum-sensing precursor induces mortality in the marine coccolithophore, Emiliania huxleyi [PDF]
, 2016 © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Frontiers in Microbiology 7 (2016): 59, doi:10.3389/fmicb.2016.00059.Interactions between ...
Deering, Robert W. +8 more
core +15 more sources
Unravelling the genome-wide contributions of specific 2-alkyl-4-quinolones and PqsE to quorum sensing in Pseudomonas aeruginosa [PDF]
, 2016 The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents.
A Bergh +64 more
core +23 more sources
BMC Chemistry, 2022 Quinolone is a privileged scaffold in medicinal chemistry and 4-Quinolone-3-Carboxamides have been reported to harbor vast therapeutic potential. However, conversion of N-1 substituted 4-Quinolone 3-Carboxylate to its corresponding carbamates is highly ...
Muhammad Shoaib Ali Gill +4 more
doaj +1 more source
SynOpen, 2020 Pd-NHC catalysed direct sulfenylation and selenylation of 3-iodo-4-quinolones has been developed. This protocol provides an alternative route for the construction of ipso-C–S and C–Se bond formation in 4-quinolones under aerobic conditions.
Prasanjit Ghosh, Sajal Das
doaj +1 more source
The role of 2,4-dihydroxyquinoline (DHQ) in Pseudomonas aeruginosa pathogenicity [PDF]
PeerJ, 2016 Bacteria synchronize group behaviors using quorum sensing, which is advantageous during an infection to thwart immune cell attack and resist deleterious changes in the environment.
Jordon D. Gruber +6 more
doaj +2 more sources
Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
Pharmaceuticals, 2022 A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in
Iván Díaz +3 more
doaj +1 more source
Molecules, 2023 Sustainable functionalization of renewable aromatics is a key step to supply our present needs for specialty chemicals and pursuing the transition to a circular, fossil-free economy.
Gabriela A. Corrêa +2 more
doaj +1 more source