Results 41 to 50 of about 61,740 (193)

Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus New pyranoflavones and trypanocidal activity of compounds isolated from Conchocarpus heterophyllus

Química Nova, 2008
The phytochemical investigation of trypanocidal extracts from leaves and stems of Conchocarpus heterophyllus (A. St.-Hil.) Kallunki & Pirani (Rutaceae) afforded new pyranoflavones along with the known compounds flavone, 7-methoxyflavone, 5-hydroxyflavone,
Alessandra Regina Pepe Ambrozin, Paulo Cezar Vieira, João Batista Fernandes, Maria Fátima das Graças Fernandes da Silva, Sérgio de Albuquerque   +4 more
doaj   +1 more source

Differential regulation of the phenazine biosynthetic operons by quorum sensing in Pseudomonas aeruginosa PAO1-N [PDF]

, 2018
The Pseudomonas aeruginosa quorum sensing (QS) network plays a key role in the adaptation to environmental changes and the control of virulence factor production in this opportunistic human pathogen. Three interlinked QS systems, namely las, rhl, and pqs,
Giordano Rampioni, Giordano Rampioni, Mathew P. Fletcher, Miguel Cámara, Paul Williams, Stephan Heeb, Steven Higgins, Steven Higgins   +7 more
core   +3 more sources

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

Analytical profiling of mutations in quinolone resistance determining region of gyrA gene among UPEC. [PDF]

PLoS ONE, 2018
Mutations in gyrA are the primary cause of quinolone resistance encountered in gram-negative clinical isolates. The prospect of this work was to analyze the role of gyrA mutations in eliciting high quinolone resistance in uropathogenic E.coli (UPEC ...
Lesley R Varughese, Meenakshi Rajpoot, Soniya Goyal, Ravinder Mehra, Vinod Chhokar, Vikas Beniwal   +5 more
doaj   +1 more source

Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci

Emerging Infectious Diseases, 2021
Expansion of quinolone-resistant Neisseria meningitidis clone ChinaCC4821-R1-C/B from sequence type (ST) 4821 clonal complex (CC4821) caused a serogroup shift from serogroup A to serogroup C invasive meningococcal disease (IMD) in China. To determine the
Mingliang Chen, Odile B. Harrison, Holly B. Bratcher, Zhiyan Bo, Keith A. Jolley, Charlene M.C. Rodrigues, James E. Bray, Qinglan Guo, Xi Zhang, Min Chen, Martin C.J. Maiden   +10 more
doaj   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Resistance pattern and molecular characterization of enterotoxigenic Escherichia coli (ETEC) strains isolated in Bangladesh [PDF]

, 2016
Enterotoxigenic Escherichia coli (ETEC) is a common cause of bacterial infection leading to acute watery diarrhea in infants and young children as well as in travellers to ETEC endemic countries.
Azmi, Ishrat J, Begum, Yasmin A, Qadri, Firdausi, Shahnaij, Mohammad, Sharmin, Salma, Sheikh, A., Svennerholm, A.-M., Talukder, K. A   +7 more
core   +6 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Fixed drug eruption pada perioral akibat obat golongan quinolone

Fixed drug eruption in the perioral due to quinolone medications

Jurnal Kedokteran Gigi Universitas Padjadjaran, 2018
Pendahuluan: Fixed Drug Eruption (FDE) adalah salah satu diagnosis reaksi hypersensitivitas tipe 4 yang bermanifestasi di kulit berbentuk makula merah kebiruan dan kadang-kadang bula diatasnya, serta muncul ditempat yang sama apabila terpapar obat yang ...
Nur Khamilatusy Solekhah, Rochman Mujayanto   +1 more
doaj   +1 more source

Mechanistic elucidation of HFIP‐enabled C–Cl bond activation in the synthesis of tetrahydroquinoline derivatives

Bulletin of the Korean Chemical Society, EarlyView.
Mechanistic studies reveal that hexafluoroisopropanol (HFIP) enables C–Cl activation of propargylic halides by stabilizing ion pairs and enhancing effective Brønsted acidity. This cooperative solvent effect allows access to cationic intermediates and promotes cascade formation of tetrahydroquinolines through cyclization and disproportionation ...
Seung Hoon Lee, Hyung Min Chi
wiley   +1 more source