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Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives [PDF]
Carbohydrate Research, 2013 A groups of novel water soluble chitosan derivatives containing 1,3,4-thiadiazole group were synthesized including 1,3,4-thiadiazole (TPCTS), 2-methyl-1,3,4-thiadiazole (MTPCTS), and 2-phenyl-1,3,4-thiadiazole (PTPCTS).
Qing Li, Jianming Ren, Guodong Gu
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4-Thiadiazole: The Biological Activities
Systematic Reviews in Pharmacy, 20184-Thiadiazole (1,3,4-thiadiazole) nucleus displayed noteworthy industrial efficiencies and has shown various biological activities, especially as a cancer chemo preventive agent. 4-Thiadiazole has been categorized as a member of family of azole that consist of thiadiazole ring.
Hiba Ibraheem +2 more
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SYNTHESIS AND METHYLATION OF SOME 1,2,4-THIADIAZOLE-5-THIONES [PDF]
Phosphorus, Sulfur and Silicon and the Related Elements, 1992 3,4-Disubstituted-1,2,4-thiadiazole-5(4H)-thiones (4) have been prepared by the treatment of 3,4-di-substituted-1,2,4-thiadiazole-5(4H)-ones (3) with P4S10.
Hikmet Agirbas, Yasar Dürüst
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Some biochemical effects of 2-ethylamino-1, 3, 4-thiadiazole
Biochemical Pharmacology, 1959Abstract It has previously been demonstrated (Kaplan et a 4 ), that the injection of large doses of nicotinamide results in a ten-fold increase in the diphosphopyridine nucleotide (DPN) content of the liver of mice. The current report shows that the nicotinamide antagonist 2-ethylamino-1,3,4-thiadiazole (EAT) does not behave as a competitive ...
Louis Shuster, Abraham Goldin
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Microwave Assisted Synthesis and Antibacterial Evaluation of 1, 3, 4-Thiadiazole Derivatives
Research Journal of Pharmacy and Technology, 20211,3,4-Thiadiazole is an important heterocyclic moiety, forms an integral core structural component of different categories of drugs such as antimicrobial, antitubercular, anti-inflammatory, antiepileptic, antiviral, antineoplastics, and analgesic agents. It is a key moiety in current discovery and designing of new drugs.
Jayalakshmi P M +2 more
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Research Journal of Pharmacy and Technology, 2018
In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and ...
Shetha. F. Al-Zubiady +2 more
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In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and ...
Shetha. F. Al-Zubiady +2 more
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[Synthesis and antimycotic activity of derivatives of 1, 3, 4-thiadiazole (3,2a) pyrimidone].
Il Farmaco; edizione scientifica, 1981As a continuation of previous research designed to obtain derivatives of 1,3,4-thiadiazole of pharmacological interest, some derivatives of 1,3,4-thiadiazole[3,2-alpha]pyrimidin-5-one and isomeric 7-one were prepared. The fungistatic activity of the products was tested in vitro against the following: Candida albicans, Candida parapsilosis, Candida ...
Russo F +3 more
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3D QSAR Studies on 1, 3, 4-Thiadiazole Derivatives: An Approach to Design Novel Anticonvulsants
Medicinal Chemistry, 2010A three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on a series of 1, 3, 4-thiadiazole derivatives reported as anticonvulsant employing self-organizing molecular field analysis (SOMFA) techniques to investigate the structural requirements for the design of novel anticonvulsant.
Suresh, Thareja +4 more
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Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides
Bioorganic & Medicinal Chemistry Letters, 2017In the present study, the synthesis of 1, 3, 4-thiadiazole-based thioglycosides were accomplished in good yields with employing a convergent synthetic route. The starting material 5-amino-1, 3, 4-thiadiazole-2-thiol and followed by a series of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thiols (4a-4j) were synthesized with different fatty acid chlorides ...
Srikanth, Vudhgiri +5 more
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PSEUDOTETRAHEDRAL COBALT(II)-COMPLEXES OF 2, 5-DIMETHYL-1, 3, 4-THIADIAZOLE
Journal of Coordination Chemistry, 1979Abstract The cobalt(II) complexes of 2, 5-dimethyl-1, 3, 4-thiadiazole (DTZ) Co(DTZ)2 X2 (X=Cl, Br, I, NO3) have been prepared and investigated. Their observed magnetic moments lie in the range 4.4–4.6 B.M. The complexes have a pseudo-tetrahedral coordination; a threefold splitting of the electronic v 2 and v 3 bands of the halide complexes indicate a ...
A. C. Fabretti +2 more
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