Results 211 to 220 of about 11,648,543 (253)

Synthetic and anti-cancer activity aspects of 1, 3, 4-thiadiazole containing bioactive molecules: A concise review

Journal of Sulfur Chemistry, 2021
Despite significant advances in understanding cancer pathogenesis, it continues to be one of the leading causes of death. Thus, there is an urgent need for the development of novel, more effective anticancer therapeutics. In recent years, small molecules
Vincent A. Obakachi, B. Kushwaha, N. Kushwaha, S. Mokoena, A. M. Ganai, Tabasum Khan Pathan, W. V. van Zyl, R. Karpoormath   +7 more
semanticscholar   +1 more source

Design, synthesis and antifungal mechanism of novel acetophenone derivatives containing 1, 3, 4-thiadiazole-2-thioethers

New Journal of Chemistry, 2022
Plant pathogenic fungi could cause significant losses to agricultural productions. To discover new pesticides with novel structures and unique mechanisms of action, a series of novel acetophenone derivatives containing 1,3,4-thiadiazole-2-thioethers...
Li Dou, Huabin Shi, Xuemei Niu, Hong Zhang, Kankan Zhang, Zhi-bing Wu   +5 more
semanticscholar   +1 more source

Enantiomeric Separation of (R)-5-(1-Hydroxyethyl)-2-(pyridine- 2-yl)-[1, 3, 4]-thiadiazole, an Intermediate of Nafithromycin on Immobilized Amylose Based Stationary Phase

Analytical Chemistry Letters, 2022
Chiral high performance liquid chromatography method for the separation of (R)-5-(1- Hydroxyethyl)-2-(pyridine-2-yl)-[1, 3, 4]-thiadiazole (R-alcohol) an intermediate of new antibiotic Nafithromycin (NFT) has been developed and validated.
Rajiv A. Jadhav, V. Ahirrao, Rushikesh H. Patil, K. More, Anil R. Tile, V. Rane, Pravin S. Sonawane, R. Yeole   +7 more
semanticscholar   +1 more source

4-Thiadiazole: The Biological Activities

Systematic Reviews in Pharmacy, 2018
4-Thiadiazole (1,3,4-thiadiazole) nucleus displayed noteworthy industrial efficiencies and has shown various biological activities, especially as a cancer chemo preventive agent. 4-Thiadiazole has been categorized as a member of family of azole that consist of thiadiazole ring.
Hiba Ibraheem, Yasmeen Al-Majedy, Ahmed Al-Amiery   +2 more
openaire   +1 more source

Liquid crystal behavior of Ag(I) complexes based on a series of mesogenic 1,3,4-thiadiazole ligands

Molecular Crystals and Liquid Crystals, 2021
2-(4-Alkoxyphenyl)-5-(p-tolyl)-1,3,4-thiadiazoles (alkoxy: O(CH2) n H, n = 1–8) ( 6a–h ) (as a series of 1,3,4-thiadiazole derivatives) and their silver(I) complexes: bis(2-(4-alkoxyphenyl)-5-(p-tolyl)-1,3,4-thiadiazole)-silver(I) complexes (alkoxy: O ...
I. H. Tomi, A. J. Al-Karawi, Al-Ameen Bariz OmarAli, Dhafir T. A. Al- Heetimi   +3 more
semanticscholar   +1 more source

Some biochemical effects of 2-ethylamino-1, 3, 4-thiadiazole

Biochemical Pharmacology, 1959
Abstract It has previously been demonstrated (Kaplan et a 4 ), that the injection of large doses of nicotinamide results in a ten-fold increase in the diphosphopyridine nucleotide (DPN) content of the liver of mice. The current report shows that the nicotinamide antagonist 2-ethylamino-1,3,4-thiadiazole (EAT) does not behave as a competitive ...
Louis Shuster, Abraham Goldin
openaire   +1 more source

Microwave Assisted Synthesis and Antibacterial Evaluation of 1, 3, 4-Thiadiazole Derivatives

Research Journal of Pharmacy and Technology, 2021
1,3,4-Thiadiazole is an important heterocyclic moiety, forms an integral core structural component of different categories of drugs such as antimicrobial, antitubercular, anti-inflammatory, antiepileptic, antiviral, antineoplastics, and analgesic agents. It is a key moiety in current discovery and designing of new drugs.
Jayalakshmi P M, Sheeba Jasmin TS, Manu Jose   +2 more
openaire   +1 more source

Synthesis and Antimicrobial activity of Piperazine analogues containing [1, 3, 4] Thiadiazole ring

Research Journal of Pharmacy and Technology, 2021
A new series of piperazine-1, 3, 4-thiadiazole has been synthesized, purified and characterized with the help of their analytical and spectral data. Structures of the synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopy. The potential antimicrobial effects of the synthesized compounds were investigated using Vibrio cholera and ...
Kottakki Naveen Kumar, Karteek Rao Amperayani, Uma Devi Parimi   +2 more
openaire   +1 more source

A new class of supramolecular liquid crystals derived from azo calix[4]arene functionalized 1,3,4-thiadiazole derivatives

New Journal of Chemistry, 2019
A new class of bowl-shaped supramolecular liquid crystals (LCs) is described derived from calix[4]arene substituted with 1,3,4-thiadiazole derivatives, inbuilt with Schiff base and ester on the lower rim and with an azo group on the upper rim with an ...
Vinay S. Sharma, Akshara P. Shah, Anuj S. Sharma   +2 more
semanticscholar   +1 more source

PSEUDOTETRAHEDRAL COBALT(II)-COMPLEXES OF 2, 5-DIMETHYL-1, 3, 4-THIADIAZOLE

Journal of Coordination Chemistry, 1979
Abstract The cobalt(II) complexes of 2, 5-dimethyl-1, 3, 4-thiadiazole (DTZ) Co(DTZ)2 X2 (X=Cl, Br, I, NO3) have been prepared and investigated. Their observed magnetic moments lie in the range 4.4–4.6 B.M. The complexes have a pseudo-tetrahedral coordination; a threefold splitting of the electronic v 2 and v 3 bands of the halide complexes indicate a ...
A. C. Fabretti, G. Peyronel, G. C. Franchini   +2 more
openaire   +1 more source