Results 191 to 200 of about 9,296,901 (229)

Design, synthesis and biological evaluation of non-glucosidal based 1,3,4-thiadiazoles as SGLT-2 inhibitors. [PDF]

Future Med Chem
Sharma S, Kumar S, Gupta J, Mittal A, Khurana N.   +4 more
europepmc   +1 more source

Azodicarboxylates: valuable reagents for the multicomponent synthesis of novel 1,3,4-thiadiazoles and imidazo[2,1-b][1,3,4]thiadiazoles

Tetrahedron, 2013
Summarization: Upon reaction of 4,5-disubstituted-N-arylaminoimidazole-2-thiones with isocyanides in the presence of azodicarboxylates (1.2 equiv) at rt, the imidazo[2,1-b][1,3,4]thiadiazoles were formed as the only reaction products in very good yields,
Tryfon Zarganes-Tzitzikas, Constantinos G Neochoritis, Julia Stephanidou-Stephanatou   +2 more
exaly   +2 more sources

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4-Thiadiazole: The Biological Activities

Systematic Reviews in Pharmacy, 2018
4-Thiadiazole (1,3,4-thiadiazole) nucleus displayed noteworthy industrial efficiencies and has shown various biological activities, especially as a cancer chemo preventive agent. 4-Thiadiazole has been categorized as a member of family of azole that consist of thiadiazole ring.
Hiba Ibraheem, Yasmeen Al-Majedy, Ahmed Al-Amiery   +2 more
openaire   +1 more source

Microwave Assisted Synthesis and Antibacterial Evaluation of 1, 3, 4-Thiadiazole Derivatives

Research Journal of Pharmacy and Technology, 2021
1,3,4-Thiadiazole is an important heterocyclic moiety, forms an integral core structural component of different categories of drugs such as antimicrobial, antitubercular, anti-inflammatory, antiepileptic, antiviral, antineoplastics, and analgesic agents. It is a key moiety in current discovery and designing of new drugs.
Jayalakshmi P M, Sheeba Jasmin TS, Manu Jose   +2 more
openaire   +1 more source

Some biochemical effects of 2-ethylamino-1, 3, 4-thiadiazole

Biochemical Pharmacology, 1959
Abstract It has previously been demonstrated (Kaplan et a 4 ), that the injection of large doses of nicotinamide results in a ten-fold increase in the diphosphopyridine nucleotide (DPN) content of the liver of mice. The current report shows that the nicotinamide antagonist 2-ethylamino-1,3,4-thiadiazole (EAT) does not behave as a competitive ...
Louis Shuster, Abraham Goldin
openaire   +1 more source

Synthesis, Characterization of New1, 3, 4-thiadiazole Derivatives with Studying their Biological Activity

Research Journal of Pharmacy and Technology, 2018
In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and ...
Shetha. F. Al-Zubiady, Zainab. H. Kadhim Al-Khafaji, Iman. M. Mohamed   +2 more
openaire   +1 more source

[Synthesis and antimycotic activity of derivatives of 1, 3, 4-thiadiazole (3,2a) pyrimidone].

Il Farmaco; edizione scientifica, 1981
As a continuation of previous research designed to obtain derivatives of 1,3,4-thiadiazole of pharmacological interest, some derivatives of 1,3,4-thiadiazole[3,2-alpha]pyrimidin-5-one and isomeric 7-one were prepared. The fungistatic activity of the products was tested in vitro against the following: Candida albicans, Candida parapsilosis, Candida ...
Russo F, Santagati M, Santagati A, BLANDINO, Giovanna   +3 more
openaire   +2 more sources

3D QSAR Studies on 1, 3, 4-Thiadiazole Derivatives: An Approach to Design Novel Anticonvulsants

Medicinal Chemistry, 2010
A three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on a series of 1, 3, 4-thiadiazole derivatives reported as anticonvulsant employing self-organizing molecular field analysis (SOMFA) techniques to investigate the structural requirements for the design of novel anticonvulsant.
Suresh, Thareja, Saurabh, Aggarwal, Abhilasha, Verma, Tilak Raj, Bhardwaj, Manoj, Kumar   +4 more
openaire   +2 more sources

Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides

Bioorganic & Medicinal Chemistry Letters, 2017
In the present study, the synthesis of 1, 3, 4-thiadiazole-based thioglycosides were accomplished in good yields with employing a convergent synthetic route. The starting material 5-amino-1, 3, 4-thiadiazole-2-thiol and followed by a series of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thiols (4a-4j) were synthesized with different fatty acid chlorides ...
Srikanth, Vudhgiri, Dhevendar, Koude, Dileep Kumar, Veeragoni, Sunil, Misra, R B N, Prasad, Ram Chandra Reddy, Jala   +5 more
openaire   +2 more sources

PSEUDOTETRAHEDRAL COBALT(II)-COMPLEXES OF 2, 5-DIMETHYL-1, 3, 4-THIADIAZOLE

Journal of Coordination Chemistry, 1979
Abstract The cobalt(II) complexes of 2, 5-dimethyl-1, 3, 4-thiadiazole (DTZ) Co(DTZ)2 X2 (X=Cl, Br, I, NO3) have been prepared and investigated. Their observed magnetic moments lie in the range 4.4–4.6 B.M. The complexes have a pseudo-tetrahedral coordination; a threefold splitting of the electronic v 2 and v 3 bands of the halide complexes indicate a ...
A. C. Fabretti, G. Peyronel, G. C. Franchini   +2 more
openaire   +1 more source