Results 1 to 10 of about 8,138 (214)
Antimicrobial Activity of 1,3,4-Thiadiazole Derivatives [PDF]
PharmaceuticalsThe 1,3,4-thiadiazole core has attracted significant attention due to its unique electronic structure, physicochemical properties, and wide-ranging pharmacological potential.
Sebastian Górecki +2 more
doaj +5 more sources
Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review [PDF]
Molecules, 2020 During recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new antitumor agents. One of them is 1,3,4-thiadiazole. This study is an attempt to collect the 1,3,4-
Sara Janowska +2 more
exaly +5 more sources
1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents [PDF]
Frontiers in Chemistry, 2022 A wide range of biological activities is exhibited by 1,3,4-thiadiazole moiety such as antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and antimicrobial.
Tulika Anthwal, Sumitra Nain
doaj +5 more sources
Diverse Biological Activities of 1,3,4-Thiadiazole Scaffold
Chemistry, 2022 The chemistry of 1,3,4-thiadiazole is one of the most interesting scaffolds for synthesizing new drug molecules due to their numerous pharmacological activities.
Sumitra Nain
exaly +3 more sources
Synthesis of 1,3,4-Thiadiazole Derivatives and Their Anticancer Evaluation. [PDF]
Int J Mol Sci, 2023 Thiadiazole derivatives have garnered significant attention in the field of medicinal chemistry due to their diverse pharmacological activities, including anticancer properties. This article presents the synthesis of a series of thiadiazole derivatives and investigates their chemical characterization and potential anticancer effects on various cell ...
Stecoza CE +8 more
europepmc +3 more sources
New 1,3,4-Thiadiazole Derivatives with Anticancer Activity. [PDF]
Molecules, 2022 We designed and synthesized the 1,3,4-thiadiazole derivatives differing in the structure of the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds was then determined in biological studies using MCF-7 and MDA-MB-231 breast cancer cells and normal cell line (fibroblasts).
Janowska S +8 more
europepmc +4 more sources
Recent Developments of 1,3,4-Thiadiazole Compounds as Anticancer Agents [PDF]
PharmaceuticalsThe World Health Organization has recently underlined the increasing global burden of cancer, with a particularly alarming impact on underserved populations.
Serena Indelicato +3 more
doaj +2 more sources
Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides [PDF]
Molecules, 2019 New 1,3,4-thiadiazole thioglycosides linked to substituted arylidine systems were synthesized via glycosylation of the prepared 1,3,4-thiadiazole thiol compounds.
Fahad M. Alminderej +4 more
doaj +3 more sources
Ultrasonics Sonochemistry, 2009 Novel substituted 1,3,4-thiadiazole and bi(1,3,4-thiadiazole) were synthesized from reaction of 1-methyl-5-oxo-3-phenyl-2-pyrazolin-4-thiocarbox-anilide with a series of different hydrazonyl halides or N,N'-diphenyl-oxalodihydrazonoyl dichloride. The reactions were carried out under both conventional and ultrasonic irradiation conditions.
Tamer S Saleh, Mohamed F Mady
exaly +3 more sources
Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides
Molecules, 2010 Starting from 4-chlorobenzoic acid, 10 new 5-(4-chlorophenyl)-N-substituted-N-1,3,4-thiadiazole-2-sulfonamide derivatives were synthesized in six-steps. Esterification of 4-chlorobenzoic acid with methanol and subsequent hydrazination, salt formation and
Zhuo Chen, Tingting Yang
exaly +3 more sources