Results 1 to 10 of about 2,906 (129)

Diverse Biological Activities of 1,3,4-Thiadiazole Scaffold

Chemistry, 2022
The chemistry of 1,3,4-thiadiazole is one of the most interesting scaffolds for synthesizing new drug molecules due to their numerous pharmacological activities.
Sarvesh Paliwal, Sumitra Nain, Nain Sumitra   +2 more
exaly   +3 more sources

Structure-Guided Optimization and Biological Validation of 1,3,4-Thiadiazole-Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions. [PDF]

Drug Dev Res
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Aksel AB, Ozgencil F, Bakar-Ates F, Gunindi HB, Massarotti A, Ozkan E, Kaya SG, Gozelle M, Ozkan Y, Eren G.   +9 more
europepmc   +2 more sources

1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents [PDF]

Frontiers in Chemistry, 2022
A wide range of biological activities is exhibited by 1,3,4-thiadiazole moiety such as antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and antimicrobial.
Tulika Anthwal, Sumitra Nain
doaj   +2 more sources

Antimicrobial Activity of 1,3,4-Thiadiazole Derivatives [PDF]

Pharmaceuticals
The 1,3,4-thiadiazole core has attracted significant attention due to its unique electronic structure, physicochemical properties, and wide-ranging pharmacological potential.
Sebastian Górecki, Agnieszka Kudelko, Monika Olesiejuk   +2 more
doaj   +2 more sources

An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α-Hemolysin by Blocking the Pullout of Its Stem Domain. [PDF]

ChemMedChem
A high‐throughput cellular screen based on Ca2+ influx in U937 monocytic cells identified thiadiazoles as small‐molecule inhibitors of α‐hemolysin, a key virulence factor of Staphylococcus aureus. The thiadiazole 1 prevents pore formation by a dual mechanism that prevents stem loop unfolding as well as membrane attachment.
Korotkov VS, Lukat P, Di Lucrezia R, Shekhar A, Degenhart C, Diestel R, Bilitewski U, Dinkel K, Blankenfeldt W, Brönstrup M.   +9 more
europepmc   +2 more sources

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity [PDF]

Arch Pharm (Weinheim)
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Mousavi A, Slapničková M, Norouzbahari M, D'Alessandro S, Foroumadi P, Peytam F, Perego F, Doleželová E, Emamgholipour Z, Tehrani M, Sadat‐Ebrahimi S, Hosseinzadeh E, Ahadi E, Firoozpour L, Bijanzadeh H, Basilico N, Zíková A, Foroumadi A.   +17 more
europepmc   +2 more sources

Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review

Molecules, 2020
During recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new antitumor agents. One of them is 1,3,4-thiadiazole. This study is an attempt to collect the 1,3,4-
Sara Janowska, Agata Paneth, Monika Wujec   +2 more
exaly   +3 more sources

Recent Developments of 1,3,4-Thiadiazole Compounds as Anticancer Agents [PDF]

Pharmaceuticals
The World Health Organization has recently underlined the increasing global burden of cancer, with a particularly alarming impact on underserved populations.
Serena Indelicato, David Bongiorno, Manuela Mauro, Stella Cascioferro   +3 more
doaj   +2 more sources

Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides

Molecules, 2010
Starting from 4-chlorobenzoic acid, 10 new 5-(4-chlorophenyl)-N-substituted-N-1,3,4-thiadiazole-2-sulfonamide derivatives were synthesized in six-steps. Esterification of 4-chlorobenzoic acid with methanol and subsequent hydrazination, salt formation and
Zhuo Chen, Weiming Xu, Song Yang
exaly   +3 more sources

Theoretical Study of Interaction Between Thiadiazole Derivatives on Fe(110) Surface [PDF]

Journal of Chemistry Letters, 2023
The theoretical performance of 4-methoxyphenyl-1,3,4-thiadiazole (AMPT), 2-Amino-5-(4-chlorophenyl)-1,3,4-thiadiazole (ACPT) and 2-amino-5-phenyl-1,3,4-thiadiazole (APT) as inhibitors of iron corrosion was assessed with a view of determining the ...
Thomas Nyijime, Habibat Chahul, Abdullahi Ayuba, FATER IORHUNA   +3 more
doaj   +1 more source