Results 11 to 20 of about 18,261 (204)

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents

Molecules, 2015
In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, MS and elemental analyses.
Nadjet Rezki, Amjad M. Al-Yahyawi, Sanaa K. Bardaweel, Fawzia F. Al-Blewi, Mohamed R. Aouad   +4 more
doaj   +2 more sources

New 1,3,4-Thiadiazole Derivatives with Anticancer Activity

Molecules, 2022
We designed and synthesized the 1,3,4-thiadiazole derivatives differing in the structure of the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds was then determined in biological studies using MCF-7 and MDA-MB-231 breast cancer cells and normal cell line (fibroblasts).
Sara Janowska, Dmytro Khylyuk, Anna Bielawska, Anna Szymanowska, Agnieszka Gornowicz, Krzysztof Bielawski, Jarosław Noworól, Sławomir Mandziuk, Monika Wujec   +8 more
openaire   +4 more sources

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

Drug Design, Development and Therapy, 2018
Georgeta Serban,1,* Oana Stanasel,2,* Eugenia Serban,3 Sanda Bota2,* 1Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania; 2Chemistry Department, Faculty of Sciences, University of Oradea, Oradea,
Serban G, Stanasel O, Serban E, Bota S
doaj   +1 more source

Synthesis of Mesoionic 1,3,4-Thiadiazole-2-Thiolates

Molbank
A reliable synthesis of C5-unsubstituted 1,3,4-thiadiazole-2-thiolates is described that avoids potentially explosive or laborious steps. This work presents a reliable method for preparing the starting material dithioformate from carbon disulfide and ...
Sean Ray Kahnert, Andreas Schmidt
doaj   +2 more sources

2,2′-[(1,3,4-Thiadiazole-2,5-diyl)bis(sulfanediyl)]diacetonitrile [PDF]

Acta Crystallographica Section E, 2013
In the title compound, C6H4N4S3, the 1,3,4-thiadiazole ring is essentially planar, with an r.m.s. deviation of 0.001 Å. The two N—C—S—C torsion angles in the molecule are −23.41 (15) and 0.62 (14)°. One
Mustafa R. Albayati, Ahmed M. M. El-Saghier, Shaaban K. Mohamed, Mehmet Akkurt, Joel T. Mague   +4 more
doaj   +2 more sources

Synthesis and Anti-inflammatory Activity of Some New 6-Aryltriazolo[3,4-b][1,3,4]thiadiazole Derivatives [PDF]

Журнал органічної та фармацевтичної хімії
A series of 6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been synthesized. Their anti-inflammatory activity has been studied in vivo in a carrageenan model of the paw inflammatory edema in rats.
Iryna I. Myrko
doaj   +2 more sources

Synthesis and Antifungal Activities of Perillyl Alcohol Based 1,3,4-Thiadiazole-Thioether Compounds. [PDF]

Chem Biodivers
A series of perillyl alcohol‐derived 1,3,4‐thiadiazole‐thioether compounds were designed, synthesized, and evaluated for their antifungal activities. Compound V15 was identified as the most potent derivative, demonstrating superior efficacy against G.
Xiong Y, Zhang Y, Cui Y, Hu M, Zhuo M, Duan W, Mo Q.   +6 more
europepmc   +2 more sources

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4-Thiadiazole-Based Heterocycles as Potential Anticancer and Antioxidant Agents. [PDF]

Chem Biol Drug Des
A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
El-Metwaly NM, Alrefaei AF, Alshareef HF, Almehmadi SJ, Alotaibi FA, Alshammari NM, Ebaid MS, Katouah HA.   +7 more
europepmc   +2 more sources

Synthesis of some Schiff's bases derivatives from aminoazo compounds

مجلة بغداد للعلوم, 2007
Reaction of,2- [( 4- amio phenyl ) diazenyl] 1,3,4- thiadiazole -5- thiol (S1) with p- chlorobenzeldehyde,3,4 – dimethoxy benzaldehyde and pyrrol-2- carbonxaldehyde gave -5- [{4-(4-chlorobenzylidene amino) phenyl} diezenyl]-1,3,4- thiadiazole-2- thiol ...
Baghdad Science Journal
doaj   +1 more source

1,3,4-Thiadiazole: A Promising Pharmacophore

Oriental Journal Of Chemistry, 2023
Active pharmaceutical ingredients (A.P.I.) are made up of various heteroatomic moieties. Numerous heterocycle scaffolds are regarded as crucial structures. More frequently, presence of various heteroatoms viz. nitrogen, sulphur, halogens, and oxygen atoms at different position in 5- or 6-membered rings contributed them as valued source of therapeutic ...
Nidhi Chaudhary, Ranjana Dubey, Tilak Ram, Hament Panwar   +3 more
openaire   +1 more source