Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides [PDF]
Molecules, 2019 New 1,3,4-thiadiazole thioglycosides linked to substituted arylidine systems were synthesized via glycosylation of the prepared 1,3,4-thiadiazole thiol compounds.
Fahad M. Alminderej +4 more
doaj +5 more sources
New 1,3,4-Thiadiazole Derivatives with Anticancer Activity. [PDF]
Molecules, 2022 We designed and synthesized the 1,3,4-thiadiazole derivatives differing in the structure of the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds was then determined in biological studies using MCF-7 and MDA-MB-231 ...
Janowska S +8 more
europepmc +5 more sources
Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents [PDF]
Molecules, 2015 In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, MS and elemental analyses.
Nadjet Rezki +4 more
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2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents [PDF]
Drug Design, Development and Therapy, 2018 Georgeta Serban,1,* Oana Stanasel,2,* Eugenia Serban,3 Sanda Bota2,* 1Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania; 2Chemistry Department, Faculty of Sciences, University of Oradea, Oradea,
Serban G, Stanasel O, Serban E, Bota S
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Synthesis of Mesoionic 1,3,4-Thiadiazole-2-Thiolates [PDF]
MolbankA reliable synthesis of C5-unsubstituted 1,3,4-thiadiazole-2-thiolates is described that avoids potentially explosive or laborious steps. This work presents a reliable method for preparing the starting material dithioformate from carbon disulfide and ...
Sean Ray Kahnert, Andreas Schmidt
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2,2′-[(1,3,4-Thiadiazole-2,5-diyl)bis(sulfanediyl)]diacetonitrile [PDF]
Acta Crystallographica Section E, 2013 In the title compound, C6H4N4S3, the 1,3,4-thiadiazole ring is essentially planar, with an r.m.s. deviation of 0.001 Å. The two N—C—S—C torsion angles in the molecule are −23.41 (15) and 0.62 (14)°. One
Mustafa R. Albayati +4 more
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Synthesis and Anti-inflammatory Activity of Some New 6-Aryltriazolo[3,4-b][1,3,4]thiadiazole Derivatives [PDF]
Журнал органічної та фармацевтичної хіміїA series of 6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been synthesized. Their anti-inflammatory activity has been studied in vivo in a carrageenan model of the paw inflammatory edema in rats.
Iryna I. Myrko
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One-pot Three-component Synthesis of Novel 1,3,4-Thiadiazole-thiazolo[3,2-a]pyrimidine Derivatives Catalyzed by Molecular Iodine [PDF]
, 2021 One-pot Three-component Synthesis of Novel 1,3,4-Thiadiazole-thiazolo[3,2-a]pyrimidine Derivatives Catalyzed by Molecular ...
Samaneh Ghaffari (11668230) +2 more
core +1 more source
Synthesis of 1,3,4-Thiadiazole Derivatives and Their Anticancer Evaluation. [PDF]
Int J Mol Sci, 2023 Thiadiazole derivatives have garnered significant attention in the field of medicinal chemistry due to their diverse pharmacological activities, including anticancer properties. This article presents the synthesis of a series of thiadiazole derivatives and investigates their chemical characterization and potential anticancer effects on various cell ...
Stecoza CE +8 more
europepmc +3 more sources
Synthesis and antiproliferative evaluation of novel 1,3,4-thiadiazole-S-alkyl derivatives based on quinazolinone [PDF]
, 2023 Thirty-five novel 1,3,4-thiadiazole-S-alkyl derivatives based on quinazolinone have been designed and synthesized. The structures of the target compounds 5a − 5p and 6a − 6s were confirmed by their IR, 1H NMR, 13C NMR, HR-ESI-MS spectroscopic data.
Yanle Men (12510268) +5 more
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