Synthesis, spectroscopic and crystal structure analysis of a compound with pharmocophoric substituent: 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)- imidazo[2,1-b] [1,3,4]thiadiazole-5-carbaldehyde [PDF]
, 2007 Imidazo[2,1-b][1,3,4] thiadiazole derivatives are significant for their various pharmacological properties. This paper reports the synthesis and structure of one of them, 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5 ...
Girija, C.R. +5 more
core +1 more source
Sulfur Bridged Multidentate Ligands Based on (Bi)pyridyl-(Bi)-1,3,4-Thiadiazolyl Conjugates
Molecules, 2003 The synthesis of a series of mixed (bi)pyridyl/(bi)1,3,4-thiadiazolyl ligands, derived from the condensation of 2-mercapto-5-methylthio-1,3,4-thiadiazole or 5-mercapto-5'-methylthio-2,2'-bi-1,3,4-thiadiazole with 2,6-bis(chloromethyl)pyridine or 6,6’
M. Teresa Clasadonte +2 more
doaj +1 more source
1,3,4-Thiadiazole: A Promising Pharmacophore
Oriental Journal Of Chemistry, 2023 Active pharmaceutical ingredients (A.P.I.) are made up of various heteroatomic moieties. Numerous heterocycle scaffolds are regarded as crucial structures. More frequently, presence of various heteroatoms viz. nitrogen, sulphur, halogens, and oxygen atoms at different position in 5- or 6-membered rings contributed them as valued source of therapeutic ...
Nidhi Chaudhary +3 more
openaire +1 more source
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME (2-AMINO-5-THIOL-1, 3, 4-THIADIAZOLE DERIVATIVES
مجلة بغداد للعلوم, 2007 Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2-amino-5-thiol-1,3,4- thiadiazole, compound B :2-(o-hydroxybenzylidine)amino-5-thiol-1,3,4-thiadiazole, compoundC: 2(2-butan-lidine)amino-5-thiol-1,3,4 ...
Baghdad Science Journal
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2023 During attempts to achieve interaction between 2-amino-5-ethyl-1,3,4-thiadiazole with oxalyl chloride and 5-mercapto-3-phenyl-1,3,4-thiadiazol-2-thione with various diacid anhydrides, we obtained two co-crystals (organic salts), namely, 2-amino-5-ethyl-1,
Lidiya Izotova +5 more
doaj +1 more source
Synthesis, Spectroscopic and Crystal Structure Analysis of 2-(4-Fluorobenzyl)-6-(4-Methoxyphenyl)Imidazo[2,1-B][1,3,4]Thiadiazole and its Morpholinomethyl Derivative [PDF]
, 2013 The preparation of 2-(4-fluorobenzyl)-6-(4-methoxyphenyl)-5-morpholin-1-ylmethyl imidazo[2,1-b][1,3,4]thiadiazole via the intermediate 2-(4-fluorobenzyl)-6-(4-methoxyphenyl)Imidazo[2,1-b][1,3,4] thiadiazole is described.
Afshan Banu, . +4 more
core +1 more source
Corrosion Inhibition Effect of Substituted Thiadiazoles on Brass
International Journal of Electrochemical Science, 2011 The corrosion inhibition of thiadiazole derivatives for brass in natural seawater has been evaluated by potentiodynamic polarisation and electrochemical impedance spectroscopic techniques.
X. Joseph Raj, N. Rajendran
doaj +1 more source
Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain [PDF]
, 2016 The antiapoptotic protein BCL 2 is overexpressed in several cancers and contributes to prolonged cell survival and chemoresistance, lending itself as an excellent target for cancer therapy.
Anderson +57 more
core +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2014 The presence of heterocyclic structures in diverse types of compounds, this is strongly indicative of the profound effect like structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic ...
Dilipkumar Pal +3 more
doaj +1 more source
Electrochemical Oxidation of 2,5-Dimercapto-1,3,4-thiadiazole on Carbon Electrodes Modified with Ru(III) Schiff Base Complex [PDF]
Kemija u Industriji, 2021 The thiol compound 2,5-dimercapto-1,3,4-thiadiazole is a potential cathode material. The redox reactions of the mentioned thiol compound are slow at room temperature but can be enhanced using electron transfer mediators.
Mirha Pazalja
doaj +1 more source