Results 181 to 190 of about 46,494 (302)

Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity. [PDF]

J Med Chem
Roshdy E, Kilic A, Mustafa M, Celik I, Sarı ZB, Simsek E, Nocentini A, Giovannuzzi S, Supuran CT, Özensoy Güler Ö, Winum JY, Abe M.   +11 more
europepmc   +1 more source

CsPI from the perianthless early-diverging Chloranthus spicatus show function on petal development in Arabidopsis thaliana [PDF]

, 2014
Kunmei Su, Zhenhuan Li, Zhiduan Chen
core   +1 more source

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors

Acta Crystallographica Section F, EarlyView.
The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima, Chiemi Mishima-Tsumagari, Mayumi Sakata-Sakuta, Ryo Iwaoka, Kunihiko Iwamoto   +4 more
wiley   +1 more source

β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors. [PDF]

Chembiochem
Sjövall F, Nilsson UJ.
europepmc   +1 more source

Chemistry of 1, 2, 4-Triazole: A Review Article

International Journal of Science and Research (IJSR), 2016
openaire   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

New indole-linked 1,2,4-triazole derivatives as dual FAK inhibitors and apoptosis inducers targeting survival and migration in triple-negative breast cancer in-vitro. [PDF]

Sci Rep
Abd El Salam HA, Abu-Shahba N, Ibrahim Fouad G, Mahmoud M, Mostafa EA, Abozeid MAM, Abo-Salem HM, Azouz RAM.   +7 more
europepmc   +1 more source

Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Dermatophyte infections of the dermis and subcutaneous tissue (i.e. deep dermatophytosis)—associated with secondary complications including pseudomycetoma and systemic dissemination—affect vulnerable populations with primary or acquired immunodeficiencies.
Aditya K. Gupta, Tong Wang, Susmita, Ditte Marie L. Saunte, Roderick Hay, Vincent Piguet   +5 more
wiley   +1 more source

Synthesis of sulfanyl derivatives of 1,2,4-triazoles <i>via</i> an acid catalyzed intramolecular cyclization of isothiosemicarbazones: structural characterization, <i>E</i>/<i>Z</i> isomerism, mechanistic insights and <i>in vitro</i> cytotoxicity. [PDF]

RSC Adv
Snisha K, Karthikeyan MC, Bhuvanesh N, Arockiam AJV, Karvembu R.   +4 more
europepmc   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source