Results 221 to 230 of about 46,073 (280)

Development of a Self‐Adjuvanting Influenza Peptide–Glycolipid Conjugate Inducing CD8+ T‐Cell Immunity

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi, Hideki Ogura, Takanori Matsumaru, Satoshi Ishido, Yukari Fujimoto   +4 more
wiley   +1 more source

Proton Tautomerism for Anhydrous Superprotonic Conduction in 1,2,3‐Triazolium Dihydrogen Phosphate Crystal

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
This study investigates the contribution of proton tautomerism to solid‐state proton conduction and achieves isotropic superprotonic conduction in acid–base single crystals. Specifically, low‐barrier isotropic superprotonic conductivity exceeding 10−3 S cm−1 is achieved in a cocrystal of 1,2,3‐triazole and phosphoric acid.
Kaito Nishioka, Shun Dekura, Tomoko Fujino, Motohiro Mizuno, Reiji Kumai, Bo Thomsen, Motoyuki Shiga, Yuta Hori, Yasuteru Shigeta, Hatsumi Mori   +9 more
wiley   +2 more sources

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Acetylcholinesterase and β-Secretase 1 Inhibitors. [PDF]

Int J Mol Sci
Drozdowska D, Pawelski D, Wróbel-Tałałaj A, Plonska-Brzezinska M, Kolesinska B, Lazny R, Seroka B, Parzych C, Ratkiewicz A.   +8 more
europepmc   +1 more source

Synthesis of 2-Fluoroalkylated Pyridines and Fluoropyridines by Thermal Denitrogenation of <i>N</i>-Fluoroalkyl-1,2,3-triazoles and Cyclization of Ketenimines. [PDF]

J Org Chem
Voltrová S, Klepetářová B, Beier P.
europepmc   +1 more source

Synthesis, Physical and Ion-Conducting Properties of 1,2,3-Triazolium Ionic Liquids. [PDF]

Molecules
Abdelhedi Miladi I, Chikhaoui M, Alaa Eddine M, Serghei A, Ben Romdhane H, Drockenmuller E.   +5 more
europepmc   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source