Results 61 to 70 of about 12,908,442 (282)

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

Synthesis, physic and chemical properties of 2-(4-R-5-(thiophene-2-ylmethyl)-4h-1,2,4-triazole-3-ylthio)acetate acids and their salts

Фармацевтичний журнал, 2018
Derivatives of 1,2,4-triazole are inherent in various types of biological activity. They can be used as pesticide and medicinal drugs (anticonvulsants, analgetics, antitumor and antibacterial).
O. A. Suhak, О. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source

Triazole-Containing [FeFe] Hydrogenase Mimics: Synthesis and Electrocatalytic Behavior

, 2019
Through a Cu-catalyzed Huisgen cycloaddition between terminal alkynes and azides (CuAAC) reaction, azide [(μ-SCH2)2N­(4-N3C6H4)­Fe2(CO)6] has demonstrated to be a robust and versatile reagent able to incorporate the [(μ-SR)2Fe2(CO)6] fragment on a wide ...
Luis Casarrubios (1483762), Antonio Caballero (543994), Fabiola Zapata (1771603), Alba Collado (1692373), Mar Gómez-Gallego (1359024), Miguel A. Sierra (1359036), Alba D. Merinero (7861760), Carmen Ramírez de Arellano (1359420)   +7 more
core   +1 more source

Core and π‐Bridge Engineering to Deconstruct Y6‐Series into Modular Non‐Fused Acceptors: DFT‐Guided Structure‐Property Map for Organic Solar Cells

Advanced Electronic Materials, EarlyView.
The rigid fused backbone of Y6‐series acceptors is deconstructed into a modular, non‐fused A‐π‐A′‐π‐A architecture. Comprehensive quantum chemical simulations reveal that strategic core and π‐bridge engineering preserves strong near‐infrared light‐harvesting and enhances intramolecular charge‐transfer character.
Qurat ul Ain, Waqas Akram, Hasan Yaqoob, Munazza Shahid, Abdul Majid, Muhammad Altaf, Christian B. Nielsen, Raja Shahid Ashraf   +7 more
wiley   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Creation, study of physical and chemical properties of 2-((4-R-5-phenethyl-4H-1,2,4-triazole-3-yl)thio)ethanоic(propanоic, benzoic)acids and salts of 2-((4-R-5-phenethyl-4H-1,2,4-triazole-3-yl)thio)ethanoic acid

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
A large number of native and foreign scientists are involved in the synthesis of 3-thio-1,2,4-triazole. Today, a huge number of drugs based on 3-thio-1,2,4-triazole has been created, including itraconazole, fluconazole, voriconazole, letrozole ...
T. V. Ihnatova, A. H. Kaplaushenko, Yu. S. Frolova   +2 more
doaj   +1 more source

Au(III) and Pt(II) Complexes of a Novel and Versatile 1,4-Disubstituted 1,2,3-Triazole-Based Ligand Possessing Diverse Secondary and Tertiary Coordinating Groups

, 2018
A novel 1,4-disubstituted 1,2,3-triazole-based ligand, 2-(4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)­propane-1,3-diamine (ptpd), which possesses pyridyl and diamino secondary and tertiary coordinating groups was synthesized in excellent yield.
Brendan Twamley (1267278), Brendan Twamley, Zehao Zhou (5729411), Darren M. Griffith, Eolann Kitteringham, Zehao Zhou, Darren Griffith (7895342), Darren M. Griffith (5729414), Eolann Kitteringham (5729408)   +8 more
core   +4 more sources

Generative and Experimental Validation of High Refractive Index Polymers via Domain Knowledge Approach with Small Data

Advanced Intelligent Discovery, EarlyView.
This research demonstrates that the combination of domain knowledge–based multiple regression, multi‐objective Bayesian optimization, and generative models is a suitable prediction tool for candidates of high refractive index polymers, even with the constraints in the model trained on limited data. The experimental validation can reproduce the proposed
Takuya Yokoo, Seigo Watanabe, Hana Matsunaga, Kenichi Oyaizu   +3 more
wiley   +1 more source

Synthesis methods of 1,2,4-triazole-3-thiones: review

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
1,2,4-Triazole-containing compounds are unique heterocyclic compounds present in an array of pharmaceuticals and biologically important compounds used in drug-discovery studies against cancer cells, microbes, and various types of diseases in the human ...
Yu. S. Frolova, A. H. Kaplaushenko, T. V. Ihnatova, T. M. Kaplaushenko   +3 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of 1,2,4-Triazoles

E-Journal of Chemistry, 2005
Several 3-(4'-nitrophenyl)-4-(4"-chloro benzamido)-5-substituted phenyl)-4H-1,2,4-triazole (3a-3e) and 3-(4'-nitrophenyl)-4-(4"-methyl benzenesulphonamido)-5-substituted phenyl)-4H-1,2,4-triazole (4a-4e) have been synthesised.
R. U. Roy, A. R. R. Desai, K. R. Desai
doaj   +1 more source