Results 1 to 10 of about 14,307 (153)

Novel microRNAs modulating ecto-5'-nucleotidase expression. [PDF]

Front Immunol, 2023
IntroductionThe expression of immune checkpoint molecules (ICMs) by cancer cells is known to counteract tumor-reactive immune responses, thereby promoting tumor immune escape.
Kordaß T, Chao TY, Osen W, Eichmüller SB.   +3 more
europepmc   +2 more sources

A rare mutation (p.F149del) of the NT5C3A gene is associated with pyrimidine 5'-nucleotidase deficiency. [PDF]

Cell Mol Biol Lett, 2022
Pyrimidine 5′-nucleotidase deficiency is a rare erythrocyte enzymopathy. Here we report two cases of hemolytic anemia in brothers of Polish origin that are associated with a very rare mutation.
Bogusławska DM, Skulski M, Bartoszewski R, Machnicka B, Heger E, Kuliczkowski K, Sikorski AF.   +6 more
europepmc   +2 more sources

Transcriptional and Metabolic Investigation in 5'-Nucleotidase Deficient Cancer Cell Lines. [PDF]

Cells, 2021
Enzymes of nucleoside and nucleotide metabolism regulate important cellular processes with potential impacts on nucleotide-unrelated parameters. We have used a set of CRISPR/Cas9-modified cell models expressing both, one, or none of the 5′-nucleotidases ...
Cadassou O, Forey P, Machon C, Petrotto E, Chettab K, Tozzi MG, Guitton J, Dumontet C, Cros-Perrial E, Jordheim LP.   +9 more
europepmc   +2 more sources

Targeted deletion of ecto-5'-nucleotidase results in retention of inosine monophosphate content in postmortem muscle of medaka (Oryzias latipes). [PDF]

Sci Rep, 2022
Inosine monophosphate (IMP) is an important indicator of meat freshness and contributes to its umami taste. An attractive strategy for enhancing umami is to suppress the IMP-degrading activity and increase the IMP content in the skeletal muscle through ...
Murakami Y, Ando M, Futamata R, Horibe T, Ueda K, Kinoshita M, Kobayashi T.   +6 more
europepmc   +2 more sources

Lack of Ecto-5'-Nucleotidase Protects Sensitized Mice against Allergen Challenge. [PDF]

Biomolecules, 2022
Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions.
Caiazzo E, Cerqua I, Turiello R, Riemma MA, De Palma G, Ialenti A, Roviezzo F, Morello S, Cicala C.   +8 more
europepmc   +2 more sources

5'-Nucleotidase Plays a Key Role in Uric Acid Metabolism of Bombyx mori. [PDF]

Cells, 2021
Uric acid (UA) is the end-product in the human purine metabolism pathway. The UA that accumulates in silkworm tissues is excreted as a nitrogen waste product.
Tang L, Yang D, Wang Y, Yang X, Chen K, Luo X, Xu J, Liu Y, Tang Z, Zhang Q, Liu Z, Huang Y.   +11 more
europepmc   +2 more sources

New Method for 5'-Nucleotidase Preparation and Evaluation of Its Catalytic Activity. [PDF]

Foods
In this study, we established a new methodology for preparing 5′−nucleotidase (5′−NT) with the aim of enhancing our understanding of its enzyme activity and laying a basis for regulating the content of umami−enhancing nucleotides in pork.
Zhang Y, Zeng Q, Zhang Y, Zhang P, Li Q, Zhou J, Dong L, Pan Z.   +7 more
europepmc   +2 more sources

Biochemical Characterization of an Arabinoside Monophosphate Specific 5'-Nucleotidase-like Enzyme from Streptomyces antibioticus. [PDF]

Biomolecules
To investigate the function of the gene penF in the pentostatin and vidarabine (Ara-A) biosynthetic gene cluster in Streptomyces antibioticus NRRL 3238, PenF was recombinantly expressed and characterized.
Liu Y, Liu X, Zhang X, Tang X, Su W, Wang Z, Wang H.   +6 more
europepmc   +2 more sources

Expression and Site-Specific Biotinylation of Human Cytosolic 5'-Nucleotidase 1A in <i>Escherichia coli</i>. [PDF]

Methods Protoc
Autoantibodies targeting cytosolic 5′-nucleotidase 1A (cN1A) are found in several autoimmune diseases, including inclusion body myositis (IBM), Sjögren’s syndrome, and systemic lupus erythematosus.
Slater N, Sooda A, Mastaglia FL, Fletcher S, Watson M, Needham M, Coudert JD.   +6 more
europepmc   +2 more sources

Ecto-5'-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells. [PDF]

Front Cell Dev Biol, 2021
Ecto-5′-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is being investigated as a target for
Rosemblatt MV, Parra-Tello B, Briceño P, Rivas-Yáñez E, Tucer S, Saavedra-Almarza J, Hörmann P, Martínez BA, Lladser Á, Rosemblatt M, Cekic C, Bono MR, Sauma D.   +12 more
europepmc   +2 more sources