Results 21 to 30 of about 14,806 (151)

Extracellular Vesicles from Bothrops jararaca Venom Are Diverse in Structure and Protein Composition and Interact with Mammalian Cells

Toxins, 2022
Snake venoms are complex cocktails of non-toxic and toxic molecules that work synergistically for the envenoming outcome. Alongside the immediate consequences, chronic manifestations and long-term sequelae can occur. Recently, extracellular vesicles (EVs)
Larissa Gonçalves-Machado, Brunno Renato Farias Verçoza, Fábio César Sousa Nogueira, Rafael Donadélli Melani, Gilberto Barbosa Domont, Silas Pessini Rodrigues, Juliany Cola Fernandes Rodrigues, Russolina Benedeta Zingali   +7 more
doaj   +1 more source

Estradiol regulation of nucleotidases in female reproductive tract epithelial cells and fibroblasts. [PDF]

PLoS ONE, 2013
The use of topical and oral adenosine derivatives in HIV prevention that need to be maintained in tissues and cells at effective levels to prevent transmission prompted us to ask whether estradiol could influence the regulation of catabolic nucleotidase ...
Zheng Shen, John V Fahey, Jack E Bodwell, Marta Rodriguez-Garcia, Richard M Rossoll, Sarah G Crist, Mickey V Patel, Charles R Wira   +7 more
doaj   +1 more source

Expression of major ectonucleotidases after cortical stab brain injury in rats: A real-time PCR study [PDF]

Archives of Biological Sciences, 2014
Ectonucleotidases are cell surface-located enzymes responsible for the extracellular degradation of nucleotides. They are comprised of several protein families: ectonucleoside triphosphate diphosphohydrolases (E-NTPDase), ectonucleotide ...
Parabucki Ana, Savić Danijela, Laketa Danijela, Peković Sanja, Stojiljković Mirjana, Nedeljković Nadežda, Bjelobaba Ivana   +6 more
doaj   +1 more source

5′-Nucleotidase and AMP-deaminase activities of liver postnuclear fraction and blood serum of rats with transplanted Guerin’s carcinoma

Біологічні студії, 2009
The dynamics of the levels of 5′-nucleotidase and AMP-deaminase activity in postnuclear fraction of rat liver and serum was studied during transplanted Guerin’s carcinoma growth in rats.
H. P. Kopylchuk, I. M. Buchkovska, O. M. Voloschuk   +2 more
doaj   +1 more source

ACTIVITY OF AMP DEAMINASE AND 5′-NUCLEOTIDASE IN THE CYTOSOLIC KIDNEY FRACTION OF RATS UNDER THE CONDITIONS OF DIFFERENT PROTEIN AND SUCROSE CONTENT IN A DIET [PDF]

Biotechnologia Acta, 2022
Aim. The goal of this work was to evaluate the activity of AMP deaminase and 5′-nucleotidase in the cytosolic kidney fraction of rats under the conditions of different protein and sucrose content in a diet./ Methods. In the study, 10-12 week old white
A. S. Boichu, O. M. Voloshchuk
doaj   +1 more source

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases

Journal of Pharmacological Sciences, 2004
Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors.
Isao Matsuoka, Satoko Ohkubo
doaj   +1 more source

Pyrimidine 5’Nucleotidase I and II Activities in Acute Leukaemias

Acta Medica, 2004
Summary: Bacground and objective: Pyrimidine 5’nucleotidase I and II activities of peripheral mononuclear cells were studied to evaluate their role in diagnosis, assessment of therapy and follow up of remission in acute leukaemias.
Haci Kemal Erdemli, Bahattin Adam, Nüket Bavbek   +2 more
doaj   +1 more source

Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors [PDF]

Royal Society Open Science, 2018
Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling.
Sidra Hassan, Pervaiz Ali Channar, Fayaz Ali Larik, Aamer Saeed, Hamid Saeed Shah, Joanna Lecka, Jean Sévigny, Jamshed Iqbal   +7 more
doaj   +1 more source

Disorders of purines and pyrimidines metabolism in human gastrointestinal tract cancer

Current Issues in Pharmacy and Medical Sciences, 2013
Patients with cancer of stomach, colon cancer and rectum showed an increase in the thymidine kinase, 5'–nucleotidase of adenylate, adenosine deaminase activities and a decrease in the thymidine phosphorylase activity, which can cause DNA biosynthesis ...
Berta Borzenko, Elena Bakurova, Ksenia Mironova   +2 more
doaj   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source