Results 111 to 120 of about 10,448 (137)

Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on in vivo L-[?-11C]DOPA turnover in the rat striatum with infusion of L-tyrosine

Journal of Neural Transmission, 1994
L-[11C]DOPA, combined with positron emission tomography (PET), has made possible the assessment of dopamine turnover in vivo. Before the evaluation of PET study with L-[11C]DOPA in the primate, the effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BH4) and/or L-tyrosine infusion on L-[11C]DOPA turnover was analyzed in the rat striatal tissue and ...
K. J. Lindner, Hideo Tsukada, Peter Bjurling, Göran Westerberg, Yasuyoshi Watanabe, Tor Kihlberg, Per Hartvig, Yoshihiro Tani, Bengt Långström   +8 more
openaire   +4 more sources

Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients With Primary Hyperaldosteronemia

Hypertension, 2016
Although hyperaldosteronemia exerts detrimental impacts on vascular endothelium in addition to elevating blood pressure, the effects and molecular mechanisms of hyperaldosteronemia on early endothelial progenitor cell (EPC)–mediated endothelial repair after arterial damage are yet to be determined.
Xiao-Yu Zhang, Sheng-Zhong Duan, Jun Tao, Fang Wu, Wen-Li Xie, Wen-Hao Xia, Wen He, Jin Li, Mei-Lin Ding, Long Chen   +9 more
openaire   +3 more sources

Enhancement of acetylcholine release in the hippocampus by 6R--erythro-5,6,7,8-tetrahydrobiopterin is mediated by 5-hydroxytryptamine

Brain Research, 1993
Recently, we reported that 6R-L-erythro-tetrahydrobiopterin (6R-BH4), a natural cofactor for L-aromatic amino acid hydroxylases, enhances in vivo release of acetylcholine (ACh) in the rat hippocampus: the enhancement was abolished after depletion of brain catecholamines and 5-hydroxytryptamine (5-HT) by pretreatment with reserpine. In the present study,
Yasutaka Takagi, Kunio Koshimura, Soichi Miwa, Yasuyoshi Watanabe, Tomoh Masaki, Tetsuya Ohue   +5 more
openaire   +4 more sources

6R-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4): A potential treatment for all symptom domains of schizophrenia

Medical Hypotheses, 2014
Current psychopharmacological treatment of schizophrenia is suboptimal and the available antipsychotic medications have little or no effect on negative and cognitive symptom domains of the disorder. 6R-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is a cofactor involved in the synthesis of dopamine, serotonin and nitric oxide which have all been ...
O. Okusaga
openaire   +4 more sources

Conformational investigation of the cofactor (6R,1′R,2′S-)-5,6,7,8-tetrahydrobiopterin

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1995
(6R,1'R,2'S)-5,6,7,8-Tetrahydrobiopterin is an essential cofactor for several enzymes. Different theoretical models (molecular mechanics, semiempirical quantum chemical calculations) investigating its stereostructure have yielded diverging answers. To clarify these issues, combined molecular mechanical and ab initio quantum chemical calculations were ...
Helmut Wachter, Christian Murr, Gilbert Reibnegger, Dietmar Fuchs, Willibald Estelberger   +4 more
openaire   +4 more sources

Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopaminergic and cholinergic receptors as evaluated by positron emission tomography in the Rhesus monkey

Journal of Neural Transmission, 1995
The effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) on the central cholinergic and dopaminergic systems in the Rhesus monkey brain were investigated by positron emission tomography (PET) with the muscarinic cholinergic receptor ligands (N-[11C]methyl-benztropine) and dopaminergic receptor ligands selective for D1, D2, and D3 subtypes ([11C]
T. Ishihara, Anders Lilja, Göran Westerberg, T. Kanai, Hirotaka Onoe, Jesper L. R. Andersson, Per Hartvig, Karl-Johan Fasth, Gunnar Antoni, Bengt Långström, Peter Bjurling, T. Ohno, Y. Watanabe, Yoshihiro Tani   +13 more
openaire   +4 more sources

Effect of 6R-l-erythro-5,6,7,8-tetrahydrobiopterin on the extracellular levels of dopamine and serotonin in the rat striatum: a microdialysis study with tyrosine or tryptophan infusion

Brain Research, 1994
The present study demonstrates the effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BH4) on turnover of dopamine and serotonin (5-HT) in rat striatum during continuous infusion of the amino acids tyrosine and tryptophan. By monitoring with microdialysis, it was found that the increase in dopamine and homovanillic acid (HVA) concentrations in rat
Hideo Tsukada, Karl-Johan Lindner, Per Hartvig, Bengt La˚ngstro¨m   +3 more
openaire   +4 more sources

Effect of 6R-l-erythro-5,6,7,8-tetrahydrobiopterin and infusion of l-tyrosine on the in vivo l-[β-11C]DOPA disposition in the monkey brain

Brain Research, 1996
The effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BH4) and L-tyrosine infusion on [11C]dopamine synthesis was analyzed in the striatum of Rhesus using positron emission tomography (PET). The rate for decarboxylation from L-[beta-11C]DOPA to [11C]dopamine was calculated using a graphical method with cerebellum as a reference region.
Yasuyoshi Watanabe, Hideo Tsukada, Johann Valtysson, Bengt Långström, Peter Bjurling, Yoshihiro Tani, K. J. Lindner, Per Hartvig, Göran Westerberg, Tor Kihlberg   +9 more
openaire   +4 more sources

Evidence for Specific Complex Formation between α-Melanocyte Stimulating Hormone and 6(R)-l-Erythro-5,6,7,8-tetrahydrobiopterin using Near Infrared Fourier Transform Raman Spectroscopy

Biochemistry, 1999
The cofactor 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6BH(4)) and its 2 and 4 electron oxidation products 7,8-dihydro-L-biopterin and L-biopterin have been shown to form 1:1 complexes with the thirteen amino acid peptide alpha-melanocyte stimulating hormone (alpha-MSH). Hydrogen bonding to the pyrimidine ring of the cofactor has been established for
Jeremy Moore, John M. Wood, Karin U. Schallreuter   +2 more
openaire   +4 more sources

Distribution of 6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin in Regional Brain Areas of Inbred Strains of Rats and Mice with Different Alcohol Preferences

Neuropsychobiology, 1996
6R-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BH4) is a coenzyme for tyrosine, tryptophan and phenylalanine hydroxylases, the former two of which are the initial and the rate-limiting enzymes in the biosynthesis of catecholamines and serotonin, respectively.
Kanji Yoshimoto, Masakazu Ogata, N Kozaki, K Uemura, K. Yayama, Setsuo Komura, Toshihide Yoshida   +6 more
openaire   +3 more sources