Results 11 to 20 of about 1,582 (168)

Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury [PDF]

Experimental and Molecular Medicine
Genotoxic therapy triggers reactive oxygen species (ROS) production and oxidative tissue injury. S-nitrosylation is a selective and reversible posttranslational modification of protein thiols by nitric oxide (NO), and 5,6,7,8-tetrahydrobiopterin (BH4) is
Yang Feng, Yahui Feng, Liming Gu, Wei Mo, Xi Wang, Bin Song, Min Hong, Fenghao Geng, Pei Huang, Hongying Yang, Wei Zhu, Yang Jiao, Qi Zhang, Wei-Qun Ding, Jianping Cao, Shuyu Zhang   +15 more
doaj   +2 more sources

Correction: Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status [PDF]

Frontiers in Pharmacology
Lan Gao, Neil Smith, Ronald Kong
doaj   +2 more sources

Age-Related Changes in Brain 6R-L-erythro-5,6,7,8-Tetrahydrobiopterin (R-THBP) and Biogenic Amine Levels in Fischer-344 Rats

Pteridines, 1991
Behavioral effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP), a co-factor for tyrosine hydroxylase and tryptophan hydroxylase, were investigated by means of ambulatory activity in mice. Single administration of R-THBP (50 and 100 mg/kg, s.c.) showed no significant effect on the mouse's ambulatory activity for 5 hr.
Tani Y., Ohno T., Ishihara T., Kanai T., Noguchi T.   +4 more
doaj   +12 more sources

No QTcF Prolongation with Sepiapterin: Results From a Thorough QT Study in Healthy Subjects at Therapeutic and Supratherapeutic Doses. [PDF]

J Clin Pharmacol
Abstract Sepiapterin and its major metabolite 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4) bind to distinct variants of phenylalanine hydroxylase (PAH), which converts excess phenylalanine to tyrosine, thereby stabilizing, enhancing, and prolonging PAH activity.
Gao L, Xue H, Darpo B, Ingalls K, Kaushik D, Smith N, Kong R, Golden L.   +7 more
europepmc   +2 more sources

UMI-77 Ameliorates Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy by Modulating the Brain-Gut Axis. [PDF]

Brain Behav
Metabolomics‐based analysis of SAE mice by brain‐gut axis found that metabolic pathway analysis indicates that these differential metabolites are mainly involved in the metabolism of linoleic acid, biosynthesis of phenylalanine, tyrosine, and tryptophan, and phenylalanine metabolism in the brain.
Ke Y, Dong C, Liu C, Ni M, Chen Y, Zhang Y, Wang Y, Xu Y, Chen G.   +8 more
europepmc   +2 more sources

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS. [PDF]

Am J Physiol Heart Circ Physiol, 2008
5,6,7,8-Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthases (NOSs). Oxidation of BH4, in the setting of diabetes and other chronic vasoinflammatory conditions, can cause cofactor insufficiency and uncoupling of endothelial NOS (eNOS), manifest by a switch from nitric oxide (NO) to superoxide production.
Crabtree MJ, Smith CL, Lam G, Goligorsky MS, Gross SS.   +4 more
europepmc   +5 more sources

Hyperoxia Depletes (6R)-5,6,7,8-Tetrahydrobiopterin Levels in the Neonatal Retina [PDF]

The American Journal of Pathology, 2015
Retinopathy of prematurity is a sight-threatening complication of premature birth caused by nitro-oxidative insult to the developing retinal vasculature during therapeutic hyperoxia exposure and later ischemia-induced neovascularization on supplemental oxygen withdrawal.
Kevin S. Edgar, Nuria Matesanz, Tom A. Gardiner, Zvonimir S. Katusic, Denise M. McDonald   +4 more
openaire   +3 more sources

Peroxidase catalysed aerobic degradation of 5,6,7,8‐tetrahydrobiopterin at physiological pH [PDF]

European Journal of Biochemistry, 1983
The aerobic degradation of 5,6,7,8‐tetrahydrobiopterin at neutral pH is catalysed by peroxidase (EC 1.11.1.7) and provides quinonoid 7,8‐dihydro(6H)biopterin which readily loses the side chain to yield 7,8‐dihydro(3H)pterin. The latter is in equilibrium with trace amounts of 6‐hydroxy‐5,6,7,8‐tetrahydropterin (covalent hydrate) Which is irreversibly ...
W L, Armarego, D, Randles, H, Taguchi
openaire   +2 more sources

Mutationen im PTS-Gen und mögliche Auswirkungen auf Funktion und Struktur der 6-Pyruvoyl-Tetrahydropterin-Synthase [PDF]

, 2002
Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA.
Preuße, Friedrich-Alexander, Prof. Dr. O. Bandmann   +1 more
core   +9 more sources

Electronic structure, ionization potential, and electron affinity of the enzyme cofactor (6R)-5,6,7,8-tetrahydrobiopterin in the gas phase, solution, and protein environments. [PDF]

J Phys Chem B, 2006
(6R)-5,6,7,8-Tetrahydrobiopterin (BH(4)) is a key cofactor involved in the electron transfer to the P(450) heme of nitric oxide synthase. We calculated the electronic structure of the neutral, cationic, and anionic forms of BH(4) in the gas phase, in solution (both dielectric and explicit water), and in the protein environment using density functional ...
Gogonea V, Shy JM, Biswas PK.
europepmc   +4 more sources