Results 21 to 30 of about 10,448 (137)

Phenylalanine hydroxylase contributes to serotonin synthesis in mice

The FASEB Journal, Volume 35, Issue 6, June 2021., 2021
Abstract Serotonin is an important signaling molecule in the periphery and in the brain. The hydroxylation of tryptophan is the first and rate‐limiting step of its synthesis. In most vertebrates, two enzymes have been described to catalyze this step, tryptophan hydroxylase (TPH) 1 and 2, with expression localized to peripheral and neuronal cells ...
Alexander Mordhorst, Priyavathi Dhandapani, Susann Matthes, Valentina Mosienko, Michael Rothe, Mihail Todiras, Julie Self, Wolf‐Hagen Schunck, Anja Schütz, Michael Bader, Natalia Alenina   +10 more
wiley   +1 more source

Sepiapterin reductase: Characteristics and role in diseases

Journal of Cellular and Molecular Medicine, Volume 24, Issue 17, Page 9495-9506, September 2020., 2020
Abstract Sepiapterin reductase, a homodimer composed of two subunits, plays an important role in the biosynthesis of tetrahydrobiopterin. Furthermore, sepiapterin reductase exhibits a wide distribution in different tissues and is associated with many diseases, including brain dysfunction, chronic pain, cardiovascular disease and cancer.
Yao Wu, Peng Chen, Li Sun, Shengtao Yuan, Zujue Cheng, Ligong Lu, Hongzhi Du, Meixiao Zhan   +7 more
wiley   +1 more source

Phenylalanine meta‐Hydroxylase: A Single Residue Mediates Mechanistic Control of Aromatic Amino Acid Hydroxylation

ChemBioChem, Volume 21, Issue 3, Page 417-422, February 3, 2020., 2020
The final biosynthetic step to meta‐tyrosine, an unnatural amino acid found in biologically active natural products, is mediated by phenylalanine meta‐hydroxylase. An integrated kinetics analysis, isotope labelling and mutational analysis study identified T202 as mediating mechanistic control of this intriguing enzyme.
Sabine Grüschow, Joanna C. Sadler, Peter J. Sharratt, Rebecca J. M. Goss   +3 more
wiley   +1 more source

Difference and Similarity of Serotonin and Pteridines to Act on Lipid Metabolism

Pteridines, 1998
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver homogenate, Krebs-Ringer phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol.
Rudzite Vera, Jurika Edite, Jirgensons Janis, Widner Bernhard, Weiss Guenter, Fuchs Dietmar   +5 more
doaj   +1 more source

Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins

Pteridines, 1995
Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L ...
Schallreuter-Wood Karin U., Wood John M.
doaj   +1 more source

Chronic Immune Stimulation May Cause Moderate Impairment of Phenylalanine 4-hydroxylase

Pteridines, 2011
Phenylalanine (4)-hydroxylase (PAH, E.C. 1.14.16.1) is located mainly in liver and converts amino acid phenylalanine (Phe) to tyrosine (Tyr). In 'classical' phenylketonuria (PKU), PAH activity is reduced, whereas in 'atypical' PKU biosynthesis of the ...
Scholl-Bürgi S, Schroecksnadel S, Jenny M, Karall D, Fuchs D   +4 more
doaj   +1 more source

The role of urinary pteridines as disease biomarkers

Pteridines, 2017
Pteridines and their derivatives function as intermediates in the metabolism of several vitamins and cofactors, and their relevance to disease has inspired new efforts to study their roles as disease biomarkers.
Burton Casey, Ma Yinfa
doaj   +1 more source

Pteridines and Lipid Metabolism

Pteridines, 1998
The effect of 9 different pteridines on fatty acid incorporation into phospholipids as well as on cholesterol and phospholipid content was compared in vitro using rat liver homogenate, Krebs-Ringer phosphate buffer containing 0.3 % albumin (pH=7.4 ...
Rudzite Vera, Jurika Edite, Baier-Bitterlich Gabriele, Widner Bernhard, Reibnegger Gilbert, Fuchs Dietmar   +5 more
doaj   +1 more source

Effects of Tetrahydrobiopterin (BH4) on S-Nitroso-N-acetyl-D,Lpenicillamine (SNAP)-Induced HL-60 Cell Death

Pteridines, 1998
First, we examined the effects of various chemical NO-donors on the cell damage in HL-60 cells. The most potent of these was S-nitroso-N-acetyl- penicillamine (SNAP).
Kojima Shuji
doaj   +1 more source

Spotlight on ROS and β3‐Adrenoreceptors Fighting in Cancer Cells

Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019
The role of ROS and RNS is a long‐standing debate in cancer. Increasing the concentration of ROS reaching the toxic threshold can be an effective strategy for the reduction of tumor cell viability. On the other hand, cancer cells, by maintaining intracellular ROS concentration at an intermediate level called “mild oxidative stress,” promote the ...
Maura Calvani, Angela Subbiani, Marina Vignoli, Claudio Favre, Rizwan Wahab   +4 more
wiley   +1 more source