Results 21 to 30 of about 1,582 (168)

Unveiling Photodegradation and Photosensitization Mechanisms of Unconjugated Pterins

Chemistry – A European Journal, Volume 29, Issue 29, May 22, 2023., 2023
Despite the crucial role of unconjugated pterins in enzymatic processes and the photosensitization of singlet oxygen and other biomolecules, the mechanism underlying the photochemistry of these chromophores is still unclear. With the help of state‐of‐the‐art quantum‐chemical calculations, we shed light into the very fast triplet‐state population, their
Enrique M. Arpa, Inés Corral
wiley   +1 more source

Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid

Acta Crystallographica Section F, Volume 78, Issue 4, Page 170-176, April 2022., 2022
The high‐resolution structure of Leishmania major pteridine reductase 1 in complex with its cofactor NADP+/NADPH and its substrate folic acid is reported. It provides insight into the active‐site rearrangements that occur during the catalytic process.Pteridine reductase 1 (PTR1) is a key enzyme of the folate pathway in protozoan parasites of the genera
Lucia Dello Iacono, Flavio Di Pisa, Stefano Mangani   +2 more
wiley   +1 more source

Genotypic variants of the tetrahydrobiopterin (BH4) biosynthesis genes in patients with hyperphenylalaninemia from different regions of Iran. [PDF]

Mol Genet Genomic Med
The clinical effect of reported variants is essential for genetic counseling and prenatal diagnosis in the patients' families and significant for the improvement of precision medicine. Abstract Background Hyperphenylalaninemia (HPA) is a metabolic disorder classified into phenylalanine‐4‐hydroxylase (PAH) and non‐PAH deficiency.
Nezhad SRK, Aligoodarzi PN, Rostami G, Shariati G, Galehdari H, Saberi A, Sedaghat A, Sedaghat A, Hamid M.   +8 more
europepmc   +2 more sources

Evidence for an arginine‐dependent route for the synthesis of NO in the model filamentous fungus Aspergillus nidulans

Environmental Microbiology, Volume 23, Issue 11, Page 6924-6939, November 2021., 2021
Summary Nitric oxide (NO) is a signalling molecule in eukaryotic and prokaryotic organisms. NO levels transiently boost upon induction of conidiation in Aspergillus nidulans. Only one pathway for NO synthesis involving nitrate reductase has been reported in filamentous fungi so far, but this does not satisfy all the NO produced in fungal cells. Here we
Antonio Franco‐Cano, Ana T. Marcos, Joseph Strauss, David Cánovas   +3 more
wiley   +1 more source

6R-L-erythro-5,6,7,8-Tetrahydrobiopterin: A Regulator of Neurotransmitter Release [PDF]

, 1993
6R-L-erythro-Tetrahydrobiopterin (6R-BH4) is a common natural cofactor for hydroxylases of phenylalanine, tyrosine and tryptophan, and is thought to play an important role in the regulation of monoamine neurotransmitter biosynthesis1. In fact, it is well known that in atypical phenylketonuria, 6R-BH4 deficiency results in severe neurological problems ...
K, Koshimura, T, Ohue, Y, Watanabe, S, Miwa   +3 more
openaire   +2 more sources

Phenylalanine hydroxylase contributes to serotonin synthesis in mice

The FASEB Journal, Volume 35, Issue 6, June 2021., 2021
Abstract Serotonin is an important signaling molecule in the periphery and in the brain. The hydroxylation of tryptophan is the first and rate‐limiting step of its synthesis. In most vertebrates, two enzymes have been described to catalyze this step, tryptophan hydroxylase (TPH) 1 and 2, with expression localized to peripheral and neuronal cells ...
Alexander Mordhorst, Priyavathi Dhandapani, Susann Matthes, Valentina Mosienko, Michael Rothe, Mihail Todiras, Julie Self, Wolf‐Hagen Schunck, Anja Schütz, Michael Bader, Natalia Alenina   +10 more
wiley   +1 more source

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Regulation of Dopaminergic Neural Transmission by Tyrosine Hydroxylase Protein at Nerve Terminals

Journal of Pharmacological Sciences, 2010
5R-l-Erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase (TH). Recently, a type of dopa-responsive dystonia (DRD) (DYT5, Segawa’s disease) was revealed to be caused by dominant mutations of the gene encoding GTP ...
Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kondo   +4 more
doaj   +1 more source

Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency [PDF]

, 2015
Tyrosine hydroxylase catalyses the hydroxylation of L-tyrosine to l-DOPA, the rate- limiting step in the synthesis of catecholamines. Mutations in the TH gene encoding tyrosine hydroxylase are associated with the autosomal recessive disorder tyrosine ...
Allegri, Gabriella, Baumann, Christian R., Becu-Villalobos, Damasia, Bindoff, Laurence A., Fingerhut, Ralph, Flydal, Marte I., Hole, Magnus, Konrad, Daniel, Korner, Germaine, Lauber-Biason, Anna, Martinez, Aurora, Noain, Daniela, Pillai, Samyuktha, Rassi, Anahita, Scherer, Tanja, Thöny, Beat, Wueest, Stephan, Ying, Ming   +17 more
core   +3 more sources

Probing the heme-thiolate oxygenase domain of inducible nitric oxide synthase with Ru(II) and Re(I) electron tunneling wires [PDF]

, 2008
Nitric oxide synthase (NOS) catalyzes the production of nitric oxide from L-arginine and dioxygen at a thiolate-ligated heme active site. Although many of the reaction intermediates are as yet unidentified, it is well established that the catalytic cycle
Belliston-Bittner, Wendy, Dunn, Alexander R., Gray, Harry B., Whited, Charlotte A., Winkler, Jay R.   +4 more
core   +1 more source

Difference and Similarity of Serotonin and Pteridines to Act on Lipid Metabolism

Pteridines, 1998
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver homogenate, Krebs-Ringer phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol.
Rudzite Vera, Jurika Edite, Jirgensons Janis, Widner Bernhard, Weiss Guenter, Fuchs Dietmar   +5 more
doaj   +1 more source