Results 31 to 40 of about 10,448 (137)
The Reaction Mechanism of Phenylalanine Hydroxylase. – A Question of Coordination
Pteridines, 2005 Phenylalanine hydroxylase (PAH) is a non-heme iron and tetrahydrobiopterin-dependent enzyme that catalyzes the hydroxylation of L-phenylalanine to L-tyrosine using dioxygen as additional substrate.
Teigen Knut +2 more
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Progress and Promise of Nitric Oxide‐Releasing Platforms
Advanced Science, Volume 5, Issue 6, June 2018., 2018 Nitric oxide (NO) is a highly potent two‐atom radical with a wide spectrum of physiological activities. However, it has short biological half‐life in human tissues and its therapeutic effect is concentration dependent and tissue‐specific. Diverse strategies designed to date to overcome the challenges associated with biological administration of NO are ...
Tao Yang +2 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2018, Issue 1, 2018., 2018 Nitric oxide synthases (NOSs) are a family of enzymes that are responsible for the synthesis of nitric oxide (NO) from the amino acid L‐arginine in the body. Among the three key NOSs, the expression of inducible NOS (iNOS) can only be induced by inflammatory stimuli and contribute to the large amount of NO production. iNOS‐derived NO plays an important
Xin Yu +6 more
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Pteridines, 2003 Although abnormalities in endothelial function are described in various insulin-resistant conditions, including obesity, diabetes, and hypertension in both humans and animal models, the underlying mechanisms are poorly understood.
Shinozaki Kazuya +3 more
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FEBS Open Bio, Volume 7, Issue 7, Page 1026-1036, July 2017., 2017 The conformation and function of mammalian phenylalanine hydroxylase is triggered by binding of its substrate, and regional motion of the Tyr138‐loop is a key element in this process. Mutagenesis of Tyr138 reported here, together with previous crystallographic‐structural modeling, infers that the functional information obtained about the Tyr138‐loop in
João Leandro +4 more
wiley +1 more source
Enzymatic Isomerization of Sepiapterin to 6-1'-Hydroxy-2' -oxopropyl 7,8-dihydropterin
Pteridines, 1989 6-1'-Hydroxy-2' -oxopropyl 7,8-dihydropterin, which has been believed to be too labile to actually exist, was produced from sepiapterin (6-lactoyl 7,8-dihydropterin).
Sueoka Terumi, Katoh Setsuko
doaj +1 more source
Extraction efficiency and quantification of dissolved metabolites in targeted marine metabolomics
Limnology and Oceanography: Methods, Volume 15, Issue 4, Page 417-428, April 2017., 2017 Abstract The field of metabolomics seeks to characterize the suite of small molecules that comprise the end‐products of cellular regulation. Metabolomics has been used in biomedical applications as well as environmental studies that explore ecological and biogeochemical questions.
Winifred M. Johnson +2 more
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Japanese Journal of Pharmacology, 1989 Behavioral effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP), a co-factor for tyrosine hydroxylase and tryptophan hydroxylase, were investigated by means of ambulatory activity in mice.
T. Asami, H. Kuribara
semanticscholar +1 more source
Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage
Biological Reviews, Volume 99, Issue 5, Page 1772-1790, October 2024.ABSTRACT Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective ...
Tae‐Kang Kim +7 more
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Hypoxia in Obesity and Diabetes: Potential Therapeutic Effects of Hyperoxia and Nitrate
Oxidative Medicine and Cellular Longevity, Volume 2017, Issue 1, 2017., 2017 The prevalence of obesity and diabetes is increasing worldwide. Obesity and diabetes are associated with oxidative stress, inflammation, endothelial dysfunction, insulin resistance, and glucose intolerance. Obesity, a chronic hypoxic state that is associated with decreased nitric oxide (NO) bioavailability, is one of the main causes of type 2 diabetes.
Reza Norouzirad +3 more
wiley +1 more source