Results 31 to 40 of about 1,582 (168)

Orientation of Pterin-6-Carboxylic Acid on Gold Capped Silicon Nanopillars Platforms: Surface Enhanced Raman Spectroscopy and Density Functional Theory Studies [PDF]

, 2015
The orientation of pterin-6-carboxylic acid on gold nanopillars was investigated by surface enhanced Raman spectroscopy and density functional theory methods.
Bertel, Linda, Boisen, Anja, Castillo, John J., Martinez Ortega, Fernando, Mendez-Sanchez, Stelia C., Rindzevicius, Tomas, Rozo, Ciro E.   +6 more
core   +1 more source

BH4-mediated enhancement of endothelial nitric oxide synthase activity reduces hyperoxia-induced endothelial damage and preserves vascular integrity in the neonate [PDF]

, 2017
Purpose: Endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) has important vaso-protective functions that are compromised in the vaso-degenerative phase of retinopathy of prematurity, owing to hyperoxia-induced depletion of the essential ...
Collins, Anthony, Edgar, Kevin S., Galvin, Orla M., Katusic, Zvonimir S., McDonald, Denise M.   +4 more
core   +1 more source

Sepiapterin reductase: Characteristics and role in diseases

Journal of Cellular and Molecular Medicine, Volume 24, Issue 17, Page 9495-9506, September 2020., 2020
Abstract Sepiapterin reductase, a homodimer composed of two subunits, plays an important role in the biosynthesis of tetrahydrobiopterin. Furthermore, sepiapterin reductase exhibits a wide distribution in different tissues and is associated with many diseases, including brain dysfunction, chronic pain, cardiovascular disease and cancer.
Yao Wu, Peng Chen, Li Sun, Shengtao Yuan, Zujue Cheng, Ligong Lu, Hongzhi Du, Meixiao Zhan   +7 more
wiley   +1 more source

Phenylalanine meta‐Hydroxylase: A Single Residue Mediates Mechanistic Control of Aromatic Amino Acid Hydroxylation

ChemBioChem, Volume 21, Issue 3, Page 417-422, February 3, 2020., 2020
The final biosynthetic step to meta‐tyrosine, an unnatural amino acid found in biologically active natural products, is mediated by phenylalanine meta‐hydroxylase. An integrated kinetics analysis, isotope labelling and mutational analysis study identified T202 as mediating mechanistic control of this intriguing enzyme.
Sabine Grüschow, Joanna C. Sadler, Peter J. Sharratt, Rebecca J. M. Goss   +3 more
wiley   +1 more source

Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins

Pteridines, 1995
Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L ...
Schallreuter-Wood Karin U., Wood John M.
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

The conformational flexibility of 5,6,7,8‐tetrahydrobiopterin and 5,6,7,8‐tetrahydroneopterin: a molecular dynamical simulation

FEBS Letters, 1995
5,6,7,8‐Tetrahydrobiopterin is an essential cofactor of diverse enzymes. Of the eight possible stereoisomers, only the 6R,1′R,2′S‐configuration is biologically active. Other stereoisomers, as well as other reduced pterins such as, e.g. 5,6,7,8‐tetrahydroneopterin, fail to exhibit significant cofactor activity.
Estelberger, Willibald, Mlekusch, Walter, Reibnegger, Gilbert   +2 more
openaire   +2 more sources

L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway [PDF]

, 2014
Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease characterized by lobular inflammation, hepatocellular ballooning, and fibrosis with an inherent risk for progression to cirrhosis and hepatocellular carcinoma (HCC)
Ikeda, Fusao, Ishikawa, Hisashi, Koike, Kazuko, Matsushita, Hiroshi, Miyake, Yasuhiro, Nouso, Kazuhiro, Seki, Hiroyuki, Shimomura, Yasuyuki, Shiraha, Hidenori, Takaki, Akinobu, Tsuzaki, Ryuichiro, Yamamoto, Kazuhide, Yasunaka, Tetsuya   +12 more
core   +2 more sources

Chronic Immune Stimulation May Cause Moderate Impairment of Phenylalanine 4-hydroxylase

Pteridines, 2011
Phenylalanine (4)-hydroxylase (PAH, E.C. 1.14.16.1) is located mainly in liver and converts amino acid phenylalanine (Phe) to tyrosine (Tyr). In 'classical' phenylketonuria (PKU), PAH activity is reduced, whereas in 'atypical' PKU biosynthesis of the ...
Scholl-Bürgi S, Schroecksnadel S, Jenny M, Karall D, Fuchs D   +4 more
doaj   +1 more source

The role of urinary pteridines as disease biomarkers

Pteridines, 2017
Pteridines and their derivatives function as intermediates in the metabolism of several vitamins and cofactors, and their relevance to disease has inspired new efforts to study their roles as disease biomarkers.
Burton Casey, Ma Yinfa
doaj   +1 more source