Results 41 to 50 of about 10,448 (137)
Pteridines, 2010 Biopterin as a stable metabolite is produced by oxidation of 5,6,7,8-tetrahydrobiopterin (BH4). It is known that many diseases may cause changes in BH4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity. There is only a limited number
Girgin Gözde +7 more
doaj +1 more source
Tracer‐based metabolomics for profiling nitric oxide metabolites in a 3D microvessels‐on‐chip model
The FASEB Journal, Volume 38, Issue 16, 31 August 2024.Endothelial dysfunction is characterized by diminished nitric oxide (NO) bioavailability—a key signaling molecule for vascular homeostasis. Here we developed a tracer‐based metabolomics approach to measure NO‐specific metabolites with mass spectrometry (MS) and show the impact of fluid flow on metabolic parameters associated with NO synthesis using 2D ...
Kanchana Pandian +5 more
wiley +1 more source
Oxygen activation in NO synthases: evidence for a direct role of the substrate
FEBS Open Bio, Volume 6, Issue 5, Page 386-397, May 2016., 2016 The reactive nitrogen species produced by nitric oxide (NO) synthases play crucial pathophysiological roles at the interface of oxidative stress and signaling processes. Using a combination of fast‐kinetics methods, resonance Raman spectroscopy and synthetic analogs of NOS substrate, we investigated the proton transfer processes involved in NOS ...
Albane Brunel +5 more
wiley +1 more source
Japanese Journal of Pharmacology, 1989 Behavioral effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP), a co-factor for tyrosine hydroxylase and tryptophan hydroxylase, were investigated by means of ambulatory activity in mice. Single administration of R-THBP (50 and 100 mg/kg, s.c.) showed no significant effect on the mouse's ambulatory activity for 5 hr.
Hisashi Kuribara, Takayasu Asami
openaire +3 more sources
Pteridines, 2013 Higher serum neopterin concentrations and kynurenine-to-tryptophan (Kyn/Trp) ratios are associated with increased mortality in patients with coronary artery disease (CAD). Preferentially, Th1-type cytokine interferon-γ stimulates tryptophan breakdown and
Mangge Harald +5 more
doaj +1 more source
Medicinal Research Reviews, Volume 44, Issue 3, Page 1055-1120, May 2024.Abstract Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of Leishmania protozoa, which are spread by the bite of infected sandflies. There are three main forms of the disease: cutaneous leishmaniasis (CL, the most common), visceral leishmaniasis (VL, also known as kala‐azar, the most serious), and mucocutaneous ...
Miguel Marín +4 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016 Vitiligo is a common chronic acquired pigmentation disorder characterized by loss of functional melanocytes from the epidermis and follicular reservoir. Among multiple hypotheses which have been proposed in the pathogenesis of vitiligo, autoimmunity and oxidative stress‐mediated toxicity in melanocytes remain most widely accepted.
Zhuhui Qiao +4 more
wiley +1 more source
Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio
Pteridines, 2013 The proinflammatory cytokine interferon (IFN) γ activates GTP-cyclohydrolase I. In turn, the production of neopterin in human monocytic cells and of 5,6,7,8-tetrahydrobiopterin (BH4) in other human cells and cells of other species is markedly upregulated.
Geisler Simon +4 more
doaj +1 more source
Mediators of Inflammation, Volume 2016, Issue 1, 2016., 2016 Background. Myocardial depression in sepsis is common, and it is associated with higher mortality. In recent years, the hypothesis that the myocardial dysfunction during sepsis could be mediated by ischemia related to decreased coronary blood flow waned and a complex mechanism was invoked to explain cardiac dysfunction in sepsis.
M. Neri +5 more
wiley +1 more source
Pteridines, 2006 5,6,7,8-Tetrahydrobiopterin (BH4) is an csscntial cofactor for production of nitric oxide (NO) by N O synthase (NOS). Nitric oxide (NO) is an important signaling mo!ecu!e for the regulation o f vita! functions such as vascular tone, neurotransmission and
Shimizu Shunichi +4 more
doaj +1 more source