Results 41 to 50 of about 1,582 (168)

Pteridines and Lipid Metabolism

Pteridines, 1998
The effect of 9 different pteridines on fatty acid incorporation into phospholipids as well as on cholesterol and phospholipid content was compared in vitro using rat liver homogenate, Krebs-Ringer phosphate buffer containing 0.3 % albumin (pH=7.4 ...
Rudzite Vera, Jurika Edite, Baier-Bitterlich Gabriele, Widner Bernhard, Reibnegger Gilbert, Fuchs Dietmar   +5 more
doaj   +1 more source

Emerging pharmacotherapy for cancer patients with cognitive dysfunction [PDF]

, 2013
Advances in the diagnosis and multi-modality treatment of cancer have increased survival rates for many cancer types leading to an increasing load of long-term sequelae of therapy, including that of cognitive dysfunction.
A Parachikova, A Prakash, B Gagnon, BP Daly, C Cunningham, C Gottesmann, CD Aluise, CJ Nelson, CM Reid, D Greene-Schloesser, D Holmes, D Jaturapatporn, D Kim, David M Ashley, DD Correa, EE Lower, EG Shaw, EJ Jacobs, EM Yazlovitskaya, ES Yang, F Joly, F Xia, Fiona M Ahlberg, G Winocur, G Winocur, H Cimarosti, HG Mar Fan, HM Conklin, J Kim, J Lindsay, JC Adair, JH Kang, JM Leoutsakos, JS Wefel, JS Wefel, JS Wefel, Justin Davis, K Gehring, K Hermelink, K Hermelink, L Blackhall, L Lundorff, M Batalo, M Berbee, M Berk, M Inouye, M Khasraw, M Khasraw, M Khasraw, MC Janelsins, ME Robbins, Michael Berk, MJR Howes, Mustafa Khasraw, N Biglia, N Volkow, PD Brown, RK Mulhern, S Kohli, SJ Thompson, SM Castellino, T Scammell, TE Wilens, TM Engber, V Dutta, V Tiwari, W Lasheen, Y Liu   +67 more
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Effects of Tetrahydrobiopterin (BH4) on S-Nitroso-N-acetyl-D,Lpenicillamine (SNAP)-Induced HL-60 Cell Death

Pteridines, 1998
First, we examined the effects of various chemical NO-donors on the cell damage in HL-60 cells. The most potent of these was S-nitroso-N-acetyl- penicillamine (SNAP).
Kojima Shuji
doaj   +1 more source

The Reaction Mechanism of Phenylalanine Hydroxylase. – A Question of Coordination

Pteridines, 2005
Phenylalanine hydroxylase (PAH) is a non-heme iron and tetrahydrobiopterin-dependent enzyme that catalyzes the hydroxylation of L-phenylalanine to L-tyrosine using dioxygen as additional substrate.
Teigen Knut, Jensen Vidar R., Martinez Aurora   +2 more
doaj   +1 more source

Measuring dopaminergic function in the 6-OHDA-lesioned rat: a comparison of PET and microdialysis [PDF]

, 2013
BACKGROUND: [(18) F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease.
A Stoessl, Anna Lee, Katherine Dinelle, Matthew D Walker, Matthew J Farrer, Rick Kornelsen, Vesna Sossi   +6 more
core   +1 more source

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches. [PDF]

, 2015
BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4 ) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients.
Brown, PR, Channon, Keith M., Heikal, L, Hussein, D, McDonnell, JM, McNeill, Eileen, Nandi, M, Starr, A, Sutton, BJ   +8 more
core   +3 more sources

Insights from a Murine Aortic Transplantation Model [PDF]

, 2016
Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown ...
Bernhard, David, Brandacher, Gerald, Cardini, Benno, Golderer, Georg, Maglione, Manuel, Messner, Barbara, Oberhuber, Rupert, Pratschke, Johann, Riede, Gregor, Steger, Christina, Watschinger, Katrin, Werner, Ernst R.   +11 more
core   +1 more source

Molecular Mechanisms of Endothelial Dysfunction in the Insulin-Resistant State: the Roles of Abnormal Pteridine Metabolism

Pteridines, 2003
Although abnormalities in endothelial function are described in various insulin-resistant conditions, including obesity, diabetes, and hypertension in both humans and animal models, the underlying mechanisms are poorly understood.
Shinozaki Kazuya, Kashiwagi Atsunori, Masada Masahiro, Okamura Tomio   +3 more
doaj   +1 more source

Blocked dihydropteridines as nitric oxide synthase activators [PDF]

, 2010
It has been shown that 6-acetyl-7,7-dimethyl-5,6,7,8-tetrahydropteridin-4(3H)-one can act as a competent cofactor for the production of nitric oxide by neuronal nitric oxide synthase (nNOS).
Daff, Simon, Gazur, Ben, Gibson, C.L., McInnes, Craig R., Morthala, Raghavendar R., Suckling, C.J.   +5 more
core  

Reactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes. [PDF]

, 2009
Vascular complications are an important pathological issue in diabetes that lead to the further functional deterioration of several organs. The balance between endothelium-dependent relaxing factors and endothelium-dependent contracting factors (EDCFs ...
Afkhami-Ardekani, Akamine, Altan, Aragno, Arcaro, Arvola, Auch-Schwelk, Belmadani, Bohlen, Boveris, Burnham, Busse, Ceriello, Chen, Clarkson, Cohen, Cosentino, Crabtree, De Vriese, De Vriess, Ding, Enderle, Feletou, Feletou, Feletou, Frustaci, Fu, Fukao, Furchgott, Gao, Garland, Ge, Gebremedhin, Giugliano, Glocker, Gluais, Gluais, Goff, Haidara, Hamaty, Harris, Head, Heygate, Huszka, Huvers, Inkster, Inoguchi, Johnstone, Kagota, Kamata, Kanie, Karasu, Katusic, Katusic, Kedziora-Kornatowska, Keegan, Kocak, Kontos, Lagaud, Lambert, Landmesser, Lassegue, Lekakis, Ling, Liu, Liu, Long, Lüscher, Lüscher, MacKenzie, Makimattila, Makimattila, Makino, Maritim, Martin, Matoba, Matoba, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, McVeigh, Moien-Afshari, Moncada, Moncada, Moncada, Morikawa, Mulhern, Nagao, Nitenberg, Okon, Olmos, Oniki, Pannirselvam, Pannirselvam, Park, Pieper, Pieper, Qian, Rabini, Raij, Rand, Rizzo, Rodriguez-Mänas, Romero, Rota, Rubanyi, San Martin, Sesso, Shemyakin, Shen, Shen, Shi, Shi, Shi, Shimokawa, Shimokwa, Shinbori, Smits, Spitaler, Su, Tang, Taniguchi, Tesfamariam, Tesfamariam, Tesfamariam, Thollon, Title, Trachte, Triggle, Turner, Vallejo, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vignini, Waldron, Waldron, Walker, Ward, Wei, West, Wigg, Yada, Yang, Yang, Yang, Yu, Zenere, Zhang   +152 more
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