Results 51 to 60 of about 10,448 (137)

Impairment of Lipid Metabolism Due to Deficiency of Pyridoxal-5-phosphate and/or Activated Immune system: its Interpretation

Pteridines, 2000
Impairment of lipid metabolism due to excess metabolite accumulation induced by pyridoxal-5-phosphate (P-5-P)-deficiency and/or stimulated immune system has been studied and interpreted.
Rudzite Vera, Jurika Edite, Jäger Matthias, Fuchs Dietmar   +3 more
doaj   +1 more source

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Regulation of Dopaminergic Neural Transmission by Tyrosine Hydroxylase Protein at Nerve Terminals

Journal of Pharmacological Sciences, 2010
5R-l-Erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase (TH). Recently, a type of dopa-responsive dystonia (DRD) (DYT5, Segawa’s disease) was revealed to be caused by dominant mutations of the gene encoding GTP ...
Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kondo   +4 more
doaj  

The conformation of 5, 6, 7, 8-tetrahydrobiopterin and 7,8-dihydrobiopterin in solution: a 1H NMR study

, 2000
5,6,7,8-tetrahydrobiopterin (BH4) is the essential cofactor for a variety of enzyme-catalyzed reactions, including the hydroxylation of aromatic amino acids, the formation of NO and glyceryl ether cleavage in rat liver (1,2).
Aurora Martínez, Khanh Kim Dao, J. Mckinney, K. Teigen, N. A. Frøystein   +4 more
semanticscholar   +1 more source

Structural Basis for Pterin Antagonism in Nitric-oxide Synthase [PDF]

Journal of Biological Chemistry, 2001
Pathological nitric oxide (NO) generation in sepsis, inflammation, and stroke may be therapeutically controlled by inhibiting NO synthases (NOS). Here we targeted the (6R)-5,6,7,8-tetrahydro-l-biopterin (H(4)Bip)-binding site of NOS, which, upon cofactor binding, maximally increases enzyme activity and NO production from substrate l-arginine. The first
Peter Kotsonis, Hans Matter, Detlev Mohr, Viola Groehn, Lothar G. Fröhlich, Hartmut Strobel, Yonghan Kang, Wolfgang Pfleiderer, Rainer Gerwig, Najim A. Al-Masoudi, Chander Raman, Michael Berg, Ursula Münch, Huiying Li, Bettie Sue Siler Masters, Pavel Martásek, Joachim Schnabel, Shahriyar Taghavi-Moghadam, Harald H.H.W. Schmidt, Thomas L. Poulos   +19 more
openaire   +3 more sources

In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2. [PDF]

Biomolecules, 2023
Arefieva AB, Komleva PD, Naumenko VS, Khotskin NV, Kulikov AV.   +4 more
europepmc   +1 more source

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications. [PDF]

Int J Mol Sci, 2022
Buglak AA, Kapitonova MA, Vechtomova YL, Telegina TA.   +3 more
europepmc   +1 more source

Sleeve gastrectomy is feasible in obese patients with phenylketonuria: A case report and literature review. [PDF]

Int J Surg Case Rep, 2023
Quarenghi M, Giana A, Turri Quarenghi R, Volonté F.   +3 more
europepmc   +1 more source

Establishing pteridine metabolism in a progressive isogenic breast cancer cell model - part II. [PDF]

Metabolomics, 2022
Rasmussen L, Foulks Z, Wu J, Burton C, Shi H.   +4 more
europepmc   +1 more source

Tetrahydrobiopterin as a Trigger for Vitiligo: Phototransformation during UV Irradiation. [PDF]

Int J Mol Sci, 2023
Telegina TA, Vechtomova YL, Borzova VA, Buglak AA.   +3 more
europepmc   +1 more source

In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH₄ Therapeutics. [PDF]

Int J Mol Sci, 2023
Hussein D.
europepmc   +1 more source