Results 51 to 60 of about 1,582 (168)
Tetrahydrobiopterin treatment in phenylketonuria:A repurposing approach [PDF]
, 2020 In phenylketonuria (PKU) patients, early diagnosis by neonatal screening and immediate institution of a phenylalanine-restricted diet can prevent severe intellectual impairment.
Evers, Roeland A F +2 more
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Spotlight on ROS and β3‐Adrenoreceptors Fighting in Cancer Cells
Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019 The role of ROS and RNS is a long‐standing debate in cancer. Increasing the concentration of ROS reaching the toxic threshold can be an effective strategy for the reduction of tumor cell viability. On the other hand, cancer cells, by maintaining intracellular ROS concentration at an intermediate level called “mild oxidative stress,” promote the ...
Maura Calvani +4 more
wiley +1 more source
Enzymatic Isomerization of Sepiapterin to 6-1'-Hydroxy-2' -oxopropyl 7,8-dihydropterin
Pteridines, 1989 6-1'-Hydroxy-2' -oxopropyl 7,8-dihydropterin, which has been believed to be too labile to actually exist, was produced from sepiapterin (6-lactoyl 7,8-dihydropterin).
Sueoka Terumi, Katoh Setsuko
doaj +1 more source
Extraction efficiency and quantification of dissolved metabolites in targeted marine metabolomics [PDF]
, 2017 © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Limnology and Oceanography: Methods 15 (2017): 417–428, doi:10.1002/lom3.10181.The field of ...
Johnson, Winifred M. +2 more
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Progress and Promise of Nitric Oxide‐Releasing Platforms
Advanced Science, Volume 5, Issue 6, June 2018., 2018 Nitric oxide (NO) is a highly potent two‐atom radical with a wide spectrum of physiological activities. However, it has short biological half‐life in human tissues and its therapeutic effect is concentration dependent and tissue‐specific. Diverse strategies designed to date to overcome the challenges associated with biological administration of NO are ...
Tao Yang +2 more
wiley +1 more source
American Journal of Primatology, Volume 87, Issue 10, October 2025.Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley +1 more source
Inhibition of tryptophan hydroxylases and monoamino oxidase-A by the proton pump inhibitor, omeprazole - in vitro and in vivo investigations [PDF]
, 2021 Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation.
Betari, Nibal +7 more
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Oxidative Medicine and Cellular Longevity, Volume 2018, Issue 1, 2018., 2018 Nitric oxide synthases (NOSs) are a family of enzymes that are responsible for the synthesis of nitric oxide (NO) from the amino acid L‐arginine in the body. Among the three key NOSs, the expression of inducible NOS (iNOS) can only be induced by inflammatory stimuli and contribute to the large amount of NO production. iNOS‐derived NO plays an important
Xin Yu +6 more
wiley +1 more source
Pteridines, 2010 Biopterin as a stable metabolite is produced by oxidation of 5,6,7,8-tetrahydrobiopterin (BH4). It is known that many diseases may cause changes in BH4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity. There is only a limited number
Girgin Gözde +7 more
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Glucocorticoid-induced hypertension and the nitric oxide system [PDF]
, 2016 Glucocorticoid hormones, both naturally occurring and synthetic, have long been recognized as a major cause of hypertension. There are well-described experimental models of glucocorticoid-induced hypertension, such as adrenocorticotropic hormone-and ...
Ong, Lee Lin (Sharon), Whitworth, Judith
core +1 more source