Results 21 to 30 of about 35,251,522 (102)

Site-Specific Introduction of (5‘S)-5‘,8-Cyclo-2‘-deoxyadenosine into Oligodeoxyribonucleotides

, 2016
Site-Specific Introduction of (5‘S)-5‘,8-Cyclo-2‘-deoxyadenosine into ...
Anthony Romieu (27583), Didier Molko (3043434), Jean Cadet (14780), Didier Gasparutto (6669)   +3 more
core   +1 more source

Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-hydroxy-2'-deoxyguanosine 5'-triphosphate) [PDF]

, 2011
8-Oxo-7,8-dihydroguanine (8-hydroxyguanine) is oxidized more easily than normal nucleobases, which can produce spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh).
Hori, Mika, Suzuki, Tetsuya, Hideyoshi Harashima, Akira Matsuda, Minakawa, Noriaki, Harashima, Hideyoshi, Noriaki Minakawa, Mika Hori, Hiroyuki Kamiya, Matsuda, Akira, Kamiya, Hiroyuki, Tetsuya Suzuki   +11 more
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Structure of (5′S)-8,5′-Cyclo-2′-deoxyguanosine in DNA

, 2016
Diastereomeric 8,5′-cyclopurine 2′-deoxynucleosides, containing a covalent bond between the deoxyribose and the purine base, represent an important class of DNA damage induced by ionizing radiation.
Ashis K. Basu (630373), Hai Huang (140371), Rajat S. Das (1277673), Michael P. Stone (1265139)   +3 more
core   +1 more source

Oxidation of 2'-Deoxyguanosine and 8-Oxo-2'-deoxyguanosine by Dimethyldioxirane [PDF]

, 2004
Oxidative damage to DNA can lead to cancer, aging, and neurological disorders. Of the four DNA bases, guanine is the most susceptible to oxidation. To help us further our knowledge of how oxidation contributes to illness and disease, it is important to ...
Degen, Diana E.
core   +1 more source

UEG Week 2014 Poster Presentations

, 2014
United European Gastroenterology Journal, Volume 2, Issue S1, Page A132-A605, October 2014.
wiley   +1 more source

An Adduct between Peroxynitrite and 2‘-Deoxyguanosine:  4,5-Dihydro-5-hydroxy-4-(nitrosooxy)-2‘-deoxyguanosine

, 2016
The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4−C5 double bond of 2‘-deoxyguanosine with ...
Thierry Douki (298019), Jean Cadet (14780), Bruce N. Ames (523848)   +2 more
core   +1 more source

Autosomal Recessive Dilated Cardiomyopathy due to DOLK Mutations Results from Abnormal Dystroglycan O-Mannosylation [PDF]

, 2011
Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they are thought to contribute considerably to sudden cardiac death and heart failure, especially in young children.
van Reeuwijk, Jeroen, Schuurs-Hoeijmakers, Janneke H. M., Lehle Ludwig, Schuurs-Hoeijmakers, J.H., Lorber, A., Lorber, Avraham, Zucker, N., Janneke H M Schuurs-Hoeijmakers, Zucker Nili, Grünewald Stephanie, de Brouwer Arjan P. M., Wevers, R.A., Steenbergen, Gerry, Lefeber, D.J., Steenbergen, G.C., Lammens, M.M.Y., Ron A Wevers, Adam Jozwiak, Schuurs-Hoeijmakers, Janneke H M, Wevers, Ron A., Huijben, K., Grunewald, S., Lefeber, Dirk J, Gruenewald, Stephanie, Wevers, Ron A, Willem M R van den Akker, van den Akker, Willem M. R., de Brouwer, Arjan P. M., van Bokhoven, H., Steenbergen Gerry, Hanna Mandel, Riemersma Moniek, Riemersma, Moniek, Gerry Steenbergen, Riemersma, M., Stephanie Grünewald, Lammens, Martin, Dirk J Lefeber, Eva Morava, Absmanner, B., Morava Eva, Verrijp, K., Knopf, Carlos, Verrijp, Kiek, Knopf, C., van Bokhoven, Hans, Brouwer, A.P.M. de, van den Akker Willem M. R., Nili Zucker, Jeroen van Reeuwijk, Mandel, H., Lammens Martin, Martin Lammens, Jozwiak, Adam, Carlos Knopf, de Brouwer, A.P., Absmanner, Birgit, Mandel Hanna, Hans van Bokhoven, Reeuwijk, J. van, Jozwiak, A., Ludwig Lehle, Schuurs-Hoeijmakers Janneke H. M., Lehle, Ludwig, Lorber Avraham, Huijben Karin, van Reeuwijk, J., Zucker, Nili, Hijben, K., van den Akker, Willem M R, Birgit Absmanner, Absmanner Birgit, Avraham Lorber, Steenbergen, G., Huijben, Karin, Wevers Ron A., Mandel, Hanna, Knopf Carlos, Kapusta, Livia, Lefeber, Dirk J., Livia Kapusta, Verrijp Kiek, van den Akker, W.M., Grunewald, Stephanie, van Bokhoven Hans, Morava, E., Akker, W.M.R. van den, Moniek Riemersma, Bokhoven, H. van, Lefeber Dirk J., Jozwiak Adam, Lehle, L., Kapusta, L., Lammens, M., van Reeuwijk Jeroen, Karin Huijben, Schuurs-Hoeijmakers, J.H.M., Morava, Eva, Kapusta Livia, Arjan P M de Brouwer, Kiek Verrijp   +100 more
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Kinetic and Structural Mechanisms of (5′S)‑8,5′-Cyclo-2′-deoxyguanosine-Induced DNA Replication Stalling

, 2016
The (5′S)-8,5′-cyclo-2′-deoxyguanosine (S-cdG) lesion is produced from reactions of DNA with hydroxyl radicals generated from ionizing radiation or endogenous oxidative metabolisms.
Wenyan Xu (1453525), Adam M. Ouellette (1682827), Storm J. Shriver (1682833), Spencer M. Anderson (1682830), Zdzislaw Wawrzak (1330530), Linlin Zhao (555492)   +5 more
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Oligonucleotide Incorporation and Base Pair Stability of 9-Deaza-2′-deoxyguanosine, an Analogue of 8-Oxo-2′-deoxyguanosine

, 2016
9-Deaza-2′-deoxyguanosine (CdG) is a C-nucleoside and an analogue of the abundant promutagen 8-oxo-2′-deoxyguanosine (OdG). Like 2′-deoxyguanosine (dG), CdG should form a stable base pair with dC, but similar to OdG, CdG contains an N7-hydrogen that ...
Carol A. Parish (669279), Michelle L. Hamm (2022451), Jennifer L. Carman (2274328), Anna J. Parker (2101213), Tyler W. E. Steele (2274331)   +4 more
core   +1 more source

Synthesis of 8-heteroaryl-2'-deoxyguanosine derivatives [PDF]

, 2008
We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2â?²-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin ...
Rivera-Sánchez, M.D.C., Gubala, V., Rivera, J.M., Hobley, G.   +3 more
core   +1 more source