Metabolic Network Analysis of Filamentous Cyanobacteria [PDF]
, 2020 Cyanobacteria were the first organisms to use oxygenic photosynthesis, converting CO2 into useful organic chemicals. However, the chemical industry has historically relied on fossil raw materials to produce organic precursors, which has contributed to ...
Norena-Caro, Daniel Alexis
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Novel Antitumoral Strategies Inducing Membrane Lipid and DNA Damage:Artificial Chemical Nucleases & the ‘ClickGene’ Project [PDF]
, 2019 This PhD project was carried out within the frame of a Marie Curie Network with the acronym ‘ClickGene’, which focuses on the development of next-generation gene silencing therapeutics, such as the artificial metallo-nucleases (AMNs).
Menounou, Georgia <1991>
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The influence of cdG on 8-oxodG excision by OGG1 and FPG glycosylases
, 2022 : Human genome is exposed to the variety of damaging factors, such as ionizing radiation. 5’,8-cyclo-2’-deoxypurines (cdPus) are well described unfavorable outcomes of DNA damage, especially devastating as a part of clustered DNA lesions (CDL).
Bolesław Karwowski, Michał Szewczuk
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Mutagenesis and Genetic Control of Translesion Synthesis Across an Abasic Site, 8,5’-Cyclopurines and \u3cem\u3eO\u3c/em\u3e\u3csup\u3e2\u3c/sup\u3e-Alkylthymidine DNA Lesions [PDF]
, 2015 DNA contains the genetic information of all living organisms. Therefore, its integrity and stability are essential for the long-term viability of the organism.
Weerasooriya, Savithri Anurada Kumari
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Epigenetic Instability Induced by DNA Base Lesion via DNA Base Excision Repair [PDF]
, 2017 DNA damage can cause genome instability, which may lead to human cancer. The most common form of DNA damage is DNA base damage, which is efficiently repaired by DNA base excision repair (BER).
Jiang, Zhongliang
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The Contribution of DNA Interstrand Crosslinks to Aging [PDF]
, 2012 DNA damage is hypothesized to be a driver of aging. In support of this, DNA damage and genetic mutations, resulting from replication of that damage, both increase in the nuclear genome as organisms age.
Robinson, Andria R
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UEG Week 2014 Poster Presentations
, 2014 United European Gastroenterology Journal, Volume 2, Issue S1, Page A132-A605, October 2014.
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Oxidative DNA Damage Modulates Trinucleotide Repeat Instability Via DNA Base Excision Repair [PDF]
, 2014 Trinucleotide repeat (TNR) expansion is the cause of more than 40 types of human neurodegenerative diseases such as Huntington’s disease. Recent studies have linked TNR expansion with oxidative DNA damage and base excision repair (BER). In this research,
Xu, Meng
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Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke [PDF]
, 2019 From gametogenesis until death an organism’s genome is under constant bombardment from endogenous and exogenous sources of DNA damage. To maintain genomic integrity amid this damage, cells have evolved responses which allow them to either preserve ...
Cartwright, Brian
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Chemistry and Biology of 8,5\u27-Cyclo-2\u27-deoxyguanosine and Other DNA Lesions
, 2013 8,5’-Cyclopurine deoxynucleosides are unique tandem lesions containing an additional covalent bond between the base and the sugar. These mutagenic and genotoxic lesions are repaired only by nucleotide excision repair (NER). It was shown that the R-cdA is
Das, Rajat S
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