Results 41 to 50 of about 35,251,522 (102)

Oligonucleotide Incorporation of 8-Thio-2‘-deoxyguanosine

, 2016
8-Thio-2‘-deoxyguanosine (SdG) is a useful analogue of the abundant promutagen 8-oxo-2‘-deoxyguanosine (OdG). Its synthesis and DNA incorporation using standard phosphoramidite chemistry is reported.
Timothy J. Gill (2486932), Michelle L. Hamm (2022451), Courtney L. Hoey (2705416), Rushina Cholera (225114)   +3 more
core   +1 more source

Base Pair Stability of 8-Chloro- and 8-Iodo-2‘-deoxyguanosine Opposite 2‘-Deoxycytidine:  Implications Regarding the Bioactivity of 8-Oxo-2‘-deoxyguanosine

, 2016
8-Oxo-2‘-deoxyguanosine (OdG) is an abundant and promutagenic damaged nucleotide that has been linked to aging and disease. To gain insight into the alternate base pairings of OdG, 8-chloro- and 8-iodo-2‘-deoxyguanosine were incorporated into ...
Anthony M. Downs (2671747), Michelle L. Hamm (2022451), Sumika Rajguru (2671744), Rushina Cholera (225114)   +3 more
core   +1 more source

Purine 5?,8-cyclo-2?-deoxynucleoside lesions in irradiated DNA

, 2016
Having their position gained among the smallest bulky DNA lesions recognized by the nucleotide excision repair (NER) enzyme, purine 5?,8-cyclo-2?-deoxynucleosides (5?,8-cPu) are increasingly attracting the interest in the field of genome integrity in ...
Chatgilialoglu C, Papadopoulos K, Terzidis MA, Krokidis MG   +3 more
core   +1 more source

Ne-22 Ion-Beam Radiation Damage to DNA: From Initial Free Radical Formation to Resulting DNA-Base Damage. [PDF]

ACS Omega, 2021
Kant M, Jaruga P, Coskun E, Ward S, Stark AD, Baumann T, Becker D, Adhikary A, Sevilla MD, Dizdaroglu M.   +9 more
europepmc   +1 more source

8-CF3-2’-deoxyguanosine as a useful nucleoside analog for 19F NMR-based structural studies of G-quadruplex structures

, 2012
Herein, a synthetic study to obtain a 2’-deoxyguanosine derivative carrying the CF3 group on the nucleobase is reported. Key reaction to obtain this building block is the trifluoromethylation step, carried out on 3’,5’-di-O-acetyl-2’-deoxyguanosine using
MUSUMECI, DOMENICA, MONTESARCHIO, DANIELA   +1 more
core  

Independent generation of C5 '-nucleosidyl radicals in thymidine and 2 '-deoxyguanosine

, 2007
The synthesis of the C5' tert-butyl ketone of thymidine 1a and 2'-deoxyguanosine 2 is achieved by reaction of 5'-C-cyano derivatives with tert-butyl lithium followed by acid hydrolysis.
Manetto Antonio, Carell Thomas, Leondiadis Leondios, Mayer Peter, Gimisis Thanasis, Georganakis Dimitris, Chatgilialoglu Chryssostomos   +6 more
core   +1 more source

G quadruplexes stabilized by 8-oxo-2’-deoxyguanosine

, 2011
Four is company: Four-stranded structures can be formed from sequences that contain non-natural analogues of 2′-deoxyguanosine. 8-Oxo-2′-deoxyguanosine, 2′-deoxyxanthosine as well as 8-oxo-2′-deoxyguanosine were found to support the formation of stable ...
Singh, Vijay, Benz, Armin, Vijay Singh, Jörg S. Hartig, Hartig, Jörg S., Armin Benz   +5 more
core   +1 more source

Σύνθεση τροποποιημένων 5',8-κυκλο-2'-δεοξυγουανοσινών για εφαρμογή τους στη διαμόρφωση νέων νανοϋλικών

, 2016
Οι πλούσιες σε γουανίνη (G) αλληλουχίες του DNA και RNA μπορούν αυθόρμητα να αυτοργανωθούν σε υπερμοριακές ελικοειδείς δομές τετραμερών δομών της γουανίνης με ιόντα μετάλλων (G-quadruplexes), οι οποίες αντιπροσωπεύουν ελκυστικούς στόχους για το ...
Γαγλία Λαμπρινή
core   +1 more source

Incorporation of 5',8-cyclo-2'deoxyadenosines by DNA repair polymerases via base excision repair. [PDF]

DNA Repair (Amst), 2022
Tsegay PS, Hernandez D, Brache C, Chatgilialoglu C, Krokidis MG, Chapagain P, Liu Y.   +6 more
europepmc   +1 more source

Facile Synthesis of O⁶-Alkyl-, O⁶-Aryl-, and Diaminopurine Nucleosides from 2‘-Deoxyguanosine

, 2016
The 3‘,5‘-bis-O-TBDMS derivative of 2‘-deoxyguanosine can be converted to its O6-alkyl and O6-aryl ethers as well as to N6-substituted diaminopurine nucleosides in two simple steps.
Larry M. Russon (2984850), Felix N. Ngassa (2510620), John C. Keeler (2510623), Mahesh K. Lakshman (1554784), John H. Hilmer (2510626), Yen Q. V. Dinh (2984847)   +5 more
core   +1 more source