Results 31 to 40 of about 128,410,485 (63)

DNA Damage Products (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines as Potential Biomarkers in Human Urine for Atherosclerosis

, 2016
We hypothesized that DNA damage products (5′R)-8,5′-cyclo-2′-deoxyadenosine (R-cdA) and (5′S)-8,5′-cyclo-2′-deoxyadenosine (S-cdA) may be well-suited biomarkers of risk and diagnosis for atherosclerosis.
Arkadiusz Jawien (2107438), Rafal Rozalski (433279), Pawel Jaruga (9759), Arkadiusz Migdalski (2107441), Miral Dizdaroglu (9761), Ryszard Olinski (433285)   +5 more
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Independent Generation of C5‘-Nucleosidyl Radicals in Thymidine and 2‘-Deoxyguanosine

, 2016
The synthesis of the C5‘ tert-butyl ketone of thymidine 1a and 2‘-deoxyguanosine 2 is achieved by reaction of 5‘-C-cyano derivatives with tert-butyl lithium followed by acid hydrolysis.
Thanasis Gimisis (2340640), Dimitris Georganakis (286875), Thomas Carell (199465), Leondios Leondiadis (375922), Chryssostomos Chatgilialoglu (458350), Peter Mayer (1464436), Antonio Manetto (2492683)   +6 more
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Synthesis of 8-heteroaryl-2'-deoxyguanosine derivatives [PDF]

, 2008
We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2â?²-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin ...
Rivera-Sánchez, M.D.C., Gubala, V., Rivera, J.M., Hobley, G.   +3 more
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Evaluation of multiple oxidation products for monitoring effects of antioxidants in Fenton oxidation of 2 '-deoxyguanosine

, 2006
The objective of this study was to investigate the influence of the two antioxidants, ascorbic acid and (+)catechin, on the oxidation of 2'-deoxyguanosine (dG), using an iron-mediated Fenton reaction.
Grey, Carl, Adlercreutz, Patrick, Adlercreutz, Patrick,, Grey, Carl,   +3 more
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Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]

, 2010
Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Rabbani, Naila, Santarius, Thomas, Larkin, Sarah J., Waris, Sahar, Fleming, Thomas, Thornalley, Paul J., Winklhofer-Roob, Brigitte M., Stratton, Michael R.   +7 more
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Radical-induced purine lesion formation is dependent on DNA helical topology

, 2016
Herein we report the quantification of purine lesions arising from gamma-radiation sourced hydroxyl radicals (HO(•)) on tertiary dsDNA helical forms of supercoiled (SC), open circular (OC) and linear (L) conformation, along with single-stranded folded ...
Chatgilialoglu, Chryssostomos, Krokidis, Marios, Molphy, Zara, Terzidis, Michael, Kellett, Andrew, Prisecaru, Andreea, Dumont, Elise, Terzidis, Michael A, RANDAZZO, ANTONIO, Krokidis, Marios G, Barron, Niall, Randazzo Antonio, Terzidis Michael A, Molphy Zara, Krokidis Marios G, Barron Niall, Kellett Andrew, Chatgilialoglu Chryssostomos, Prisecaru Andreea, Dumont Elise   +19 more
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New Insights into the Reaction Paths of Hydroxyl Radicals with 2′-Deoxyguanosine

, 2016
The reaction of HO• radical with 2′-deoxyguanosine is intensively studied as a model for DNA damage. Several aspects related to the reaction paths responsible for the most relevant lesions are not well understood.
Krzysztof Bobrowski (1590658), Mila D’Angelantonio (1268343), Gabriel Kciuk (1590655), Chryssostomos Chatgilialoglu (458350)   +3 more
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Mutagenicity and Genotoxicity of (5′S)‑8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)‑8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4

, 2015
Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine (cdG).
Ashis K. Basu (630373), Varsha Pednekar (1308057), Savithri Weerasooriya (630371), Vijay P. Jasti (630372)   +3 more
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Chemical structures of 8-hydroxy-2′-deoxyguanosine (8-oxodG), 5-hydroxymethyluracil (5-HMUra) and cimetidine (used as internal standard - IS).

, 2013
Chemical structures of 8-hydroxy-2′-deoxyguanosine (8-oxodG), 5-hydroxymethyluracil (5-HMUra) and cimetidine (used as internal standard - IS).
Pedro Silva (219069), Fernando Aveiro (385795), José S. Câmara (385797), Jorge Pereira (385796), Berta Mendes (385794)   +4 more
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Σύνθεση τροποποιημένων 5',8-κυκλο-2'-δεοξυγουανοσινών για εφαρμογή τους στη διαμόρφωση νέων νανοϋλικών

, 2016
Οι πλούσιες σε γουανίνη (G) αλληλουχίες του DNA και RNA μπορούν αυθόρμητα να αυτοργανωθούν σε υπερμοριακές ελικοειδείς δομές τετραμερών δομών της γουανίνης με ιόντα μετάλλων (G-quadruplexes), οι οποίες αντιπροσωπεύουν ελκυστικούς στόχους για το ...
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