Results 31 to 40 of about 1,400 (108)

Oligonucleotide Incorporation and Base Pair Stability of 9-Deaza-2′-deoxyguanosine, an Analogue of 8-Oxo-2′-deoxyguanosine

, 2016
9-Deaza-2′-deoxyguanosine (CdG) is a C-nucleoside and an analogue of the abundant promutagen 8-oxo-2′-deoxyguanosine (OdG). Like 2′-deoxyguanosine (dG), CdG should form a stable base pair with dC, but similar to OdG, CdG contains an N7-hydrogen that ...
Carol A. Parish (669279), Michelle L. Hamm (2022451), Jennifer L. Carman (2274328), Anna J. Parker (2101213), Tyler W. E. Steele (2274331)   +4 more
core   +1 more source

Multi-Log Cytotoxicity of Carbocyclic 2′-Deoxyguanosine in HSV-TK-Expressing Human Tumor Cells [PDF]

, 2002
Ganciclovir (GCV) is widely used as a prodrug for selective activation in tumor cells expressing herpes simplex virus thymidine kinase (HSV-TK) because of its ability to induce multi-log cytotoxicity to HSV-TK-expressing as well as nonexpressing ...
Boucher, Paul D., Secrist, John A., Robinson, Blaine W., Murphy, Patrick J., Blobaum, Anna L., Parker, William B., Zerbe, Laura, Shewach, Donna S., Vuletich, Jennifer   +8 more
core   +1 more source

(5′S)-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli

, 2011
8,5′-Cyclopurines, making up an important class of ionizing radiation-induced tandem DNA damage, are repaired only by nucleotide excision repair (NER).
Vijay P. Jasti, Zou, Yue, Das, Rajat S., Hilton, Benjamin A., Savithri Weerasooriya, Yue Zou, Basu, Ashis K., Benjamin A. Hilton, Jasti, Vijay P., Rajat S. Das, Ashis K. Basu, Weerasooriya, Savithri   +11 more
core   +1 more source

RFT1 deficiency in three novel CDG patients [PDF]

, 2009
The medical significance of N-glycosylation is underlined by a group of inherited human disorders called Congenital Disorders of Glycosylation (CDG). One key step in the biosynthesis of the Glc(3)Man(9)GlcNAc(2)-PP-dolichol precursor, essential for N ...
Ludman, M D, Matthijs, G, Vleugels, W, Freeze, H H, Haeuptle, M A, Jaeken, J, Ng, B G, Michalski, J C, Hennet, T, Battini, R, Dionisi-Vici, C, Foulquier, F   +11 more
core   +1 more source

(5′S)-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli

, 2015
8,5′-Cyclopurines, making up an important class of ionizing radiation-induced tandem DNA damage, are repaired only by nucleotide excision repair (NER).
Ashis K. Basu (630373), Yue Zou (15851), Rajat S. Das (1277673), Benjamin A. Hilton (1277670), Savithri Weerasooriya (630371), Vijay P. Jasti (630372)   +5 more
core   +1 more source

UEG Week 2014 Poster Presentations

, 2014
United European Gastroenterology Journal, Volume 2, Issue S1, Page A132-A605, October 2014.
wiley   +1 more source

Dietary mannose supplementation in phosphomannomutase 2 deficiency (PMM2-CDG)

, 2020
Background!#!PMM2-CDG (CDG-Ia) is the most frequent N-glycosylation disorder. While supplying mannose to PMM2-deficient fibroblasts corrects the altered N-glycosylation in vitro, short term therapeutic approaches with mannose supplementation in PMM2-CDG ...
DuChesne, Ingrid, Marquardt, Thorsten, Grüneberg, Marianne, Reunert, Janine, Taday, Roman   +4 more
core   +1 more source

Mutagenicity and Genotoxicity of (5′S)‑8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)‑8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4

, 2015
Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine (cdG).
Ashis K. Basu (630373), Varsha Pednekar (1308057), Savithri Weerasooriya (630371), Vijay P. Jasti (630372)   +3 more
core   +1 more source

DataSheet4_SRD5A3-CDG: Emerging Phenotypic Features of an Ultrarare CDG Subtype.pdf

, 2021
Background: SRD5A3-CDG is a rare N-glycosylation defect caused by steroid 5 alpha reductase type 3 deficiency. Its key feature is an early severe visual impairment with variable ocular anomalies often leading to diagnosis.
Kshitij Mankad (6749432), Preeya Rehsi (11774657), Nazreen Kamarus Jaman (11774654), Ulrike Löbel (3325251), Stephanie Grunewald (1460986), Robert H. Henderson (11774660)   +5 more
core   +1 more source

COG5-CDG with a Mild Neurohepatic Presentation

, 2011
The conserved oligomeric Golgi (COG) complex is an eight subunit protein involved in the retrograde transport of Golgi components. It affects the localization of several Golgi glycosyltransferases and hence is involved in N- and O-glycosylation.
Wong, K.Y., Wong, RMS, Garozzo, D., Sturiale, L, Garozzo, D, Fung, C.W., Wong, VCN, D. Garozzo, Jaeken, Jaak, Sturiale, L., Wong, R., Fung, CW, J. Jaeken, Matthijs, G, Wong, V., K. Y. Wong, L. Sturiale, Jaeken, J, C. W. Fung, Matthijs, Gert, V. Wong, Wong, KY, G. Matthijs, R. Wong   +23 more
core   +1 more source