Results 11 to 20 of about 128,410,485 (63)
A lipophilic “fully-anti” dodecamer from a (5′S)-5′,8-cyclo-2′-deoxyguanosine
, 2014 The self-assembly of a lipophilic derivative of (5'S)-5',8-cyclo-2'-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated.
Baldassarri Enrico J. +6 more
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Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. [PDF]
, 2010 Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and ...
R. Rozalski +31 more
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Stability of N‑Glycosidic Bond of (5′S)‑8,5′-Cyclo-2′-deoxyguanosine
, 2016 8,5′-Cyclopurine deoxynucleosides are unique tandem lesions containing an additional covalent bond between the base and the sugar. These mutagenic and genotoxic lesions are repaired only by nucleotide excision repair. The N-glycosidic (or C1′-N9) bond of
Ashis K. Basu (630373) +4 more
core +1 more source
, 2016 Exposure of aqueous solutions of DNA to X- or γ-rays, which induces the hydroxyl radical as one of the major reactive oxygen species (ROS), can result in the generation of a battery of single-nucleobase and bulky DNA lesions. These include the (5′R) and (
Candace R. Guerrero (1331547) +2 more
core +1 more source
8-Fluoro-N-2-isobutyryl-2′-deoxyguanosine: Synthesis and Reactivity
, 2020 3′,5′-O-Bis(tert-butyldimethylsilyl)-8-fluoro-N-2-isobutyryl-2′-deoxyguanosine was synthesized from 3′,5′-O-bis(tert-butyldimethylsilyl)-N-2-isobutyryl-2′-deoxyguanosine by the treatment with N-fluorobenzenesulfonimide.
Andrei Solodinin +3 more
core +1 more source
Structures of (5′S)-8,5′-Cyclo-2′-deoxyguanosine Mismatched with dA or dT
, 2015 Diastereomeric 8,5′-cyclopurine 2′-deoxynucleosides, containing a covalent bond between the deoxyribose and the purine base, are induced in DNA by ionizing radiation.
Ashis K. Basu (630373) +3 more
core +1 more source
Chemistry and Biology of 8,5\u27-Cyclo-2\u27-deoxyguanosine and Other DNA Lesions
, 2013 8,5’-Cyclopurine deoxynucleosides are unique tandem lesions containing an additional covalent bond between the base and the sugar. These mutagenic and genotoxic lesions are repaired only by nucleotide excision repair (NER). It was shown that the R-cdA is
Das, Rajat S
core +1 more source
Structure of (5′S)-8,5′-Cyclo-2′-deoxyguanosine in DNA
, 2016 Diastereomeric 8,5′-cyclopurine 2′-deoxynucleosides, containing a covalent bond between the deoxyribose and the purine base, represent an important class of DNA damage induced by ionizing radiation.
Ashis K. Basu (630373) +3 more
core +1 more source
Oxidation of 2'-Deoxyguanosine and 8-Oxo-2'-deoxyguanosine by Dimethyldioxirane [PDF]
, 2004 Oxidative damage to DNA can lead to cancer, aging, and neurological disorders. Of the four DNA bases, guanine is the most susceptible to oxidation. To help us further our knowledge of how oxidation contributes to illness and disease, it is important to ...
Degen, Diana E.
core +1 more source
Independent generation of C5 '-nucleosidyl radicals in thymidine and 2 '-deoxyguanosine
, 2007 The synthesis of the C5' tert-butyl ketone of thymidine 1a and 2'-deoxyguanosine 2 is achieved by reaction of 5'-C-cyano derivatives with tert-butyl lithium followed by acid hydrolysis.
Manetto Antonio +6 more
core +3 more sources