The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
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DNA Damage, Oxidative Stress and Related Metabolic By-Products in Cancer and Environmental Studies [PDF]
, 2022 Computational fluid dynamics (CFD), which uses numerical analysis to predict and model complex flow behaviors and transport processes, has become a mainstream tool in engineering process research and development.
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Biomimetic Radical Chemistry and Applications [PDF]
, 2020 The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level.
Chatgilialoglu, Chryssostomos
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Detection of Oxidation Products of 5-Methyl-2′-Deoxycytidine in Arabidopsis DNA [PDF]
, 2013 Epigenetic regulations play important roles in plant development and adaptation to environmental stress. Recent studies from mammalian systems have demonstrated the involvement of ten-eleven translocation (Tet) family of dioxygenases in the generation ...
A Maiti +40 more
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New insights into the reaction paths of hydroxyl radicals with purine moieties in DNA and double-stranded oligodeoxynucleotides [PDF]
, 2019 The reaction of hydroxyl radical (HO•) with DNA produces many primary reactive species and many lesions as final products. In this study, we have examined the optical spectra of intermediate species derived from the reaction of HO• with a variety of ...
Barata Vallejo, Sebastian +7 more
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Radiobiology Textbook:Space Radiobiology [PDF]
, 2023 The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history ...
Arena, Carmen +24 more
core +4 more sources
Biological Evaluation of DNA Biomarkers in a Chemically Defined and Site-Specific Manner [PDF]
, 2019 As described elsewhere in this Special Issue on biomarkers, much progress has been made in the detection of modified DNA within organisms at endogenous and exogenous levels of exposure to chemical species, including putative carcinogens and ...
Bian, Ke +3 more
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Chemistry meets biology in colitis-associated carcinogenesis [PDF]
, 2013 The intestine comprises an exceptional venue for a dynamic and complex interplay of numerous chemical and biological processes. Here, multiple chemical and biological systems, including the intestinal tissue itself, its associated immune system, the gut ...
Dedon, Peter C. +4 more
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A 5\u27, 8-cyclo-2\u27-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β. [PDF]
, 2014 5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation.
Chatgilialoglu, Chryssostomos +6 more
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Oxidative DNA damage modulates genome and epigenome integrity via base excision repair [PDF]
, 2021 Oxidative DNA damage is one of the leading causes of genome instability, cell death, and diseases. It is repaired by DNA base excision repair (BER), during which repair and translesion DNA polymerases may incorporate damaged nucleotides and mediate RNA ...
Tsegay, Pawlos S.
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