Results 121 to 130 of about 12,326,283 (294)
Angewandte Chemie, EarlyView.An iron‐photocatalyzed unsymmetrical 1,2‐hetero(atom)difunctionalization of alkenes enables to install orthogonal C–Cl and C–O (alkoxyamine) handles which provides access to diverse nucleophiles via complementary reactivity (SN and photoredox) at two distinct sites. Detailed mechanistic studies elucidate interesting features of the iron catalytic cycle.
Amrita Chaudhuri +5 more
wiley +2 more sources
Asian Journal of AndrologyThe aim of this investigation was to determine the optimal storage medium for testicular hypothermic transportation and identify the ideal concentration for the application of the protective agent 5-aminolevulinic acid (5-ALA).
Meng-Hui Ma +8 more
doaj +1 more source
Angewandte Chemie, EarlyView.We report the computational design of de novo proteins that bind Mn(salen)‐based complexes (L1) using Rosetta FastDesign and verified by AlphaFold2. After screening, the catalytic activity for the promising design (dnMSBP) toward enantioselective sulfoxidation of thioanisole was optimized based on its crystal structure. With 10 different substrates, we
Jing‐Xiang Wang +6 more
wiley +2 more sources
Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis
Angewandte Chemie, EarlyView.Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi +6 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Gal‐SeNBD‐oleamide is an activatable photosensitizer (PS) with efficient uptake and selective, β‐galactosidase‐triggered activation in cancer cells, enabling efficient photodynamic ablation of glioma cells directly in brain tissue slices from mouse preclinical models and human glioblastoma patients.
Utsa Karmakar +18 more
wiley +2 more sources
Photodiagnosis and Photodynamic TherapyBackground: Transurethral resection of bladder tumor (TURBT) using photodynamic diagnosis (PDD) with 5-aminolevulinic acid hydrochloride (5-ALA) to treat non-muscle-invasive bladder cancer (NMIBC) frequently results in hypotension being reported as a ...
Hideo Fukuhara +8 more
doaj +1 more source