Results 101 to 110 of about 84,780,597 (237)
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
The World Journal of Men's HealthPurpose: This study aimed to investigate the biomolecular effects of finasteride on rat brain tissue during and after discontinuation. Materials and Methods: Twenty-four 14-week-old male Wistar rats were randomly assigned to three groups: Group 1 ...
Young Hyo Choi +5 more
doaj +1 more source
Advanced Science, EarlyView.FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun +13 more
wiley +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Advanced Science, EarlyView.Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao +13 more
wiley +1 more source
Risks and side effects in the medical management of benign prostatic hyperplasia
Prostate InternationalBenign prostatic hyperplasia affects up to 80% of men in their lifetime. It causes bladder outflow obstruction, leading to lower urinary tract symptoms, which can have a large impact on quality of life.
Abdulghafour Halawani +5 more
doaj +1 more source
Suicidal ideation in patients undergoing treatment with 5α-reductase inhibitors [PDF]
Background: There have been concerns raised by patients and regulatory agencies after the emerging of reports on men who had used finasteride and developed psychiatric adverse effects such as suicidal ideation.
Silva , Ana +3 more
core +1 more source
Advanced Science, EarlyView.Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima +18 more
wiley +1 more source
Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome
Annals of Neurology, EarlyView.Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca +24 more
wiley +1 more source
Human steroid 5-alpha reductase, isoform S5A2_HUMAN.
, 2013 Enzyme human steroid 5-alpha reductase, isoform S5A2_HUMAN (SRD5A2 gene) in the Cladogram from Main Cluster using TreeGraph2. The number after HUMAN indicates the length of the protein.
Annamaria Vernone (399045) +2 more
core +1 more source