Results 111 to 120 of about 84,780,597 (237)
Angewandte Chemie, EarlyView.A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang +15 more
wiley +1 more source
Design and Synthesis of 1,2,4-Oxadiazole Derivatives as Non-Steroidal 5 Alpha-Reductase Inhibitors
, 2009 The purpose of this study was to synthesize compounds in which the 1,2,4- oxadiazole moiety replaced the amide bond of ONO3805 and to evaluate its 5 alpha-reductase inhibitory activity as a potential benign prostatic hyperplasia therapeutic target.
CHERN, JI-WANG, 陳基旺
core
Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae
Angewandte Chemie, EarlyView.The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern +9 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Dual‐Function Cosubstrates Enable Threonine Dehydrogenase‐Driven Chemoenzymatic Pyrrole Synthesis
Angewandte Chemie International Edition, EarlyView.Classical Knorr chemistry meets contemporary biocatalysis. Threonine dehydrogenase generates aminoacetone from l‐threonine, which is directly intercepted in a chemoenzymatic Knorr pyrrole synthesis. A dual‐function β‐dicarbonyl substrate serves as both pyrrole precursor and hydride acceptor for integrated NAD+ recycling, affording substituted pyrroles ...
Valentina Jurkaš +8 more
wiley +1 more source
PIC50PRED: A PIC50 PREDICTION TOOL FOR 5-ALPHA REDUCTASE ENZYME [PDF]
, 2016 Objectives: Prostate cancer is a major health burden all over the world. 5-alpha reductase (5AR) enzyme is a significant drug target for prostatecancer. Identification of drug targets and their inhibitors are a challenging task in drug designing.
Madagi, Shivakumar, Balekundri, Urvashi
core +1 more source
5-alpha reductase inhibitors use in prostatic disease and beyond. [PDF]
Transl Androl Urol, 2023 Chislett B +5 more
europepmc +1 more source
Antipsychotic-Like Properties of 5-alpha-Reductase Inhibitors
, 2008 Recent evidence indicates that neuroactive steroids may participate in the pathogenesis of schizophrenia spectrum disorders, yet the mechanisms of this involvement are elusive.
Bortolato M +7 more
core +1 more source
Animal Research and One Health, EarlyView.We conducted a longitudinal trial across nursery, growing, and finishing phases, showing that phytochemical supplementation as a potential antibiotic alternative reduced potential pathogens and promoted beneficial Lactobacillus amylovorus in the nursery phase, and enriched amino acid and carbohydrate metabolism pathways (prediction) during finishing ...
Ziyu Liu +11 more
wiley +1 more source