Results 131 to 140 of about 84,780,597 (237)

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

5-Alpha Reductase Inhibitors and Prostate Cancer Mortality among Men with Regular Access to Screening and Health Care. [PDF]

Cancer Epidemiol Biomarkers Prev, 2022
Vaselkiv JB, Ceraolo C, Wilson KM, Pernar CH, Rencsok EM, Stopsack KH, Grob ST, Plym A, Giovannucci EL, Olumi AF, Kibel AS, Preston MA, Mucci LA.   +12 more
europepmc   +1 more source

Mechanism based representation of the active site of 5-[alpha]-reductase (5AR)

, 1998
In the present study, we have attempted to determine a detailed representation of the 5 alpha-Reductase (5AR) active site involving the elucidation of the transition state for the steroid delta 4 reduction reaction (the 'NADPH-substrate' complex), onto ...
Denison, Sophie, Ahmed, Sabbir, Sophie Denison, Sabbir Ahmed   +3 more
core   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis

Frontiers in Pharmacology
PurposeNumerous prior analyses have highlighted a potential link between androgen suppression therapy (AST) and bladder cancer (BCa). However, there is a notable gap in research specifically examining the influence of finasteride on BCa risk and clinical
Ailing Yu, Ailing Yu, Ailing Yu, Ailing Yu, Ailing Yu, Zian Bai, Zian Bai, Zian Bai, Zian Bai, Yijie Wang, Yijie Wang, Yijie Wang, Yijie Wang, Zhen Luo, Zhen Luo, Zhen Luo, Zhen Luo, Xiaochen Du, Mengxin Chen, Shuang Wen, Honglong Wang, Xiaoying Yuan, Chunyu Yang, Shanshan Bai, Bo Fan, Bo Fan, Bo Fan, Bo Fan   +27 more
doaj   +1 more source

5-Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia. [PDF]

J Pathol, 2022
Joseph DB, Henry GH, Malewska A, Reese JC, Mauck RJ, Gahan JC, Hutchinson RC, Mohler JL, Roehrborn CG, Strand DW.   +9 more
europepmc   +1 more source

Spatial Proteomics Identifies Distinct Synovial Microenvironments in Hip and Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis (OA) is a heterogeneous joint disease, yet mechanistic insights derive predominantly from knee OA and are often extrapolated to other joints. We investigated joint‐associated differences in the spatial molecular organization of hip and knee OA synovium.
Peng Xie, Antonia R. Sun, Zhengtan Zheng, Yunkun Qu, Feng Gao, Christina Theodoropoulos, Nicholas Matigian, Zhiyong Li, Ross Crawford, Indira Prasadam   +9 more
wiley   +1 more source

5-alpha reductase inhibitors (5-ARi) with or without alpha-blockers (α-B) for Benign Prostatic Hyperplasia do NOT lower the risk of incident Bladder Cancer: United States insurance claims data. [PDF]

World J Urol, 2023
Del Giudice F, Belladelli F, Glover F, Basran S, Li S, Mulloy E, Pradere B, Soria F, Krajewski W, Nair R, Muncey W, Seranio N, Eisenberg ML.   +12 more
europepmc   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

The Risk of Venous Thromboembolism (VTE) in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors (5ARIs). [PDF]

Clin Epidemiol, 2021
Ayodele O, Cabral HJ, McManus D, Jick S.
europepmc   +1 more source